Van Hooreweghe, Stefan; Jan Yperman Ziekenhuis, Ieper, Belgium > Department of Anesthesia
Carella, Michele ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation ; Université de Liège - ULiège > Département des sciences cliniques ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Vermeylen Kris; ZAS Ziekenhuis Aan De Stroom, Wilrijk, Belgium > Department of Anesthesia
Language :
English
Title :
Maximal Dosage of Local Anesthetics in Regional Anesthesia Techniques: narrative review and experts’ advice
Gitman M, Barrington MJ. Local Anesthetic Systemic Toxicity: A Review of Recent Case Reports and Registries. Reg Anesth Pain Med. 2018 Jan;1.
Drasner K. Local Anesthetic Systemic Toxicity: A Historical Perspective. Reg Anesth Pain Med. 2010 Mar;35(2):162–6.
Gordh T. Xylocain – a new local analgesic. Anaesthesia. 1949 Mar;4(1):4–9.
Albright GA. Cardiac Arrest Following Regional Anesthesia with Etidocaine or Bupivacaine. Anesthesiology. 1979 Oct 1;51(4):285–7.
Horlocker T, Wedel D. Local anesthetic toxicity—does product labeling reflect actual risk? Reg Anesth Pain Med. 2002 Nov;27(6):562–7.
Dhunér K-G. Clinical Experience With Marcaine® (Lac-43), A New Local Anaesthetic. Acta Anaesthesiol Scand. 1966 Oct;10(s23):395–401.
Groban L. Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model. Reg Anesth Pain Med. 2003 Jan;28(1):3–11.
Ladd LA, Chang DHT, Wilson KA, Copeland SE, Plummer JL, Mather LE. Effects of CNS Site-directed Carotid Arterial Infusions of Bupivacaine, Levobupivacaine, and Ropivacaine in Sheep. Anesthesiology. 2002 Aug 1;97(2):418–28.
Mather L, Copeland S, Ladd L. Acute Toxicity of Local Anesthetics: Underlying Pharmacokinetic and Pharmacodynamic Concepts. Reg Anesth Pain Med. 2005 Nov;30(6):553–66.
Mulroy M. Local Anesthetics: Helpful Science, but Don’t Forget the Basic Clinical Safety Steps. Reg Anesth Pain Med. 2005 Nov;30(6):513–5.
Rosenberg P, Veering B, Urmey W. Maximum recommended doses of local anesthetics: A multifactorial concept. Reg Anesth Pain Med. 2004 Dec;29(6):564–75.
Moore DC, Bridenbaugh LD, Thompson GE, Balfour RI, Horton WG. Factors Determining Dosages of Amide-type Local Anesthetic Drugs. Anesthesiology. 1977 Sept 1;47(3):263–8.
Reynolds F. Maximum Recommended Doses of Local Anesthetics: A Constant Cause of Confusion. Reg Anesth Pain Med. 2005 May;30(3):314–6.
Nestor CC, Ng C, Sepulveda P, Irwin MG. Pharmacological and clinical implications of local anaesthetic mixtures: a narrative review. Anaesthesia. 2022 Mar;77(3):339–50.
Taylor A, McLeod G. Basic pharmacology of local anaesthetics. BJA Educ. 2020 Feb;20(2):34–41.
Arthur GR, Covino BG. Pharmacokinetics of local anaesthetics. Baillières Clin Anaesthesiol. 1991 Dec;5(3):635–58.
Brodsky JB, Mariano ER. Regional anaesthesia in the obese patient: Lost landmarks and evolving ultrasound guidance. Best Pract Res Clin Anaesthesiol. 2011 Mar;25(1):61–72.
De Cassai A, Zarantonello F, Pistollato E, Pettenuzzo T, Busetto V, Sella N, et al. Regional anesthesia in obese patients: Challenges, considerations, and solutions. Saudi J Anaesth. 2025 Apr;19(2):221–6.
Benet LZ, Hoener B. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther. 2002 Mar;71(3):115–21.
Anell-Olofsson M, Ahmadi S, Lönnqvist PA, Eksborg S, Von Horn H, Bartocci M. Plasma concentrations of alpha-1-acid glycoprotein in preterm and term newborns: influence of mode of delivery and implications for plasma protein binding of local anaesthetics. Br J Anaesth. 2018 Aug;121(2):427–31.
Neal JM, Mulroy MF, Weinberg GL. American Society of Regional Anesthesia and Pain Medicine Checklist for Managing Local Anesthetic Systemic Toxicity: 2012 Version. Reg Anesth Pain Med. 2012;37(1):16–8.
Sung HJ, Ok SH, Sohn JY, Son YH, Kim JK, Lee SH, et al. Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility. J Biomed Biotechnol. 2012;2012:1–7.
Macfarlane AJR, Gitman M, Bornstein KJ, El-Boghdadly K, Weinberg G. Updates in our understanding of local anaesthetic systemic toxicity: a narrative review. Anaesthesia. 2021 Jan;76(S1):27–39.
El-Boghdadly K, Pawa A, Chin KJ. Local anesthetic systemic toxicity: current perspectives. Local Reg Anesth. 2018 Aug;Volume 11:35–44.
Mulroy M. Systemic toxicity and cardiotoxicity from local anesthetics: Incidence and preventive measures. Reg Anesth Pain Med. 2002 Nov;27(6):556–61.
Christie LE, Picard J, Weinberg GL. Local anaesthetic systemic toxicity. BJA Educ. 2015 June 1;15(3):136–42.
Borgeat A. Reply from the authors. Br J Anaesth. 2013 Mar;110(3):482.
