Impact of pre-existing subclinical depressive symptoms on the mental health of older adults during the COVID-19-related confinements: assessment of moderating factors including meditation training.

Touron, Edelweiss; Gonneaud, Julie; Paly, Léo; Delarue, Marion; Hébert, Oriane; Mézenge, Florence; Fauvel, Séverine; Vivien, Denis; de La Sayette, Vincent; Poisnel, Géraldine; Marchant, Natalie L; Chételat, Gaël; Medit-Ageing Research Group

doi:10.1038/s41598-025-99059-9

Article (Scientific journals)

Impact of pre-existing subclinical depressive symptoms on the mental health of older adults during the COVID-19-related confinements: assessment of moderating factors including meditation training.

Touron, Edelweiss; Gonneaud, Julie; Paly, Léo et al.

2025 • In Scientific Reports, 15 (1), p. 15958

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/348662

DOI
10.1038/s41598-025-99059-9

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40335630

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Keywords :

Anxiety symptoms; COVID-19 pandemic; Depressive symptoms; Meditation; Older adults; Humans; Aged; Female; Male; Anxiety/psychology; Aged, 80 and over; SARS-CoV-2; Meditation/psychology; COVID-19/psychology; COVID-19/epidemiology; Depression/psychology; Depression/therapy; Mental Health; Quarantine/psychology; Anxiety; COVID-19; Depression; Quarantine; Multidisciplinary

Abstract :

[en] The COVID-19 pandemic significantly challenged mental health of populations worldwide. We aimed to assess changes in mental health of cognitively unimpaired (CU) older adults with pre-existing subclinical depressive symptoms during pandemic-related confinements, and the factors that could modulate these changes. CU older adults with (DepS, n = 53) and without (NoDepS, n = 47) pre-existing subclinical depressive symptoms (defined using the Geriatric Depression Scale at baseline) from the Age-Well randomized controlled trial (NCT02977819) were included - for whom data at baseline, post-intervention visits and during the two national confinements were available. The 18-month meditation or non-native language training intervention was completed before the pandemic. DepS, compared to NoDepS, had higher levels of depressive and anxiety symptoms at all assessments, including confinements. DepS had a greater increase in anxiety than NoDepS between the two confinements, and this increase was associated with greater ruminative brooding at baseline, but was not moderated by the meditation training intervention or by meditation practice during confinements. Pre-existing subclinical depressive symptoms in older adults contribute to mental health deterioration during confinements, with rumination being the main factor involved - stressing the need to treat these symptoms.

Disciplines :

Neurosciences & behavior

Author, co-author :

Touron, Edelweiss; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Gonneaud, Julie; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Paly, Léo; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Delarue, Marion; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Hébert, Oriane; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Mézenge, Florence; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Fauvel, Séverine; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

Vivien, Denis; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France ; Département de Recherche Clinique, CHU de Caen-Normandie, Caen, France

de La Sayette, Vincent; Service de Neurologie CHU de Caen-Normandie, Caen, France

Poisnel, Géraldine; Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen cedex 5, France

More authors (3 more)

Other collaborator :

Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; Université de Liège - ULiège > GIGA > GIGA Platforms - In Vivo Imaging

Language :

English

Title :

Impact of pre-existing subclinical depressive symptoms on the mental health of older adults during the COVID-19-related confinements: assessment of moderating factors including meditation training.

Publication date :

07 May 2025

Journal title :

Scientific Reports

eISSN :

2045-2322

Publisher :

Nature Research

Volume :

Issue :

Pages :

15958

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.nature.com/articles/s41598-025-99059-9.pdf

Funding text :

Dr Touron reported grants from French Ministry of Higher Education and Research (PhD grant). Dr Gonneaud was supported by a Young Researcher Grant from the Fondation Alzheimer and Fondation de France. Dr Poisnel, Dr Marchant and Dr Ch\u00E9telat reported grants from European Union\u2019s Horizon 2020 Research and Innovation Program under grant agreement No 667696 during the conduct of the study. Dr Ch\u00E9telat reported grants, personal fees and nonfinancial support from Institut National de la Sant\u00E9 et de la Recherche M\u00E9dicale (INSERM); personal fees from Fondation Entrepreneurs MMA, grants and personal fees from Fondation Alzheimer, grants from R\u00E9gion Normandie, grants from Fondation Recherche Alzheimer, grants from Association France Alzheimer, outside the submitted work. No other disclosures were reported.The Age-Well randomized clinical trial is part of the Medit-Ageing project and is funded through the European Union\u2019s Horizon 2020 Research and Innovation Program (grant 667696), Institut National de la Sant\u00E9 et de la Recherche M\u00E9dicale, R\u00E9gion Normandie, and Fondation MMA des Entrepreneurs du Futur.

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