United Nations Inter-agency Group for Child Mortality Estimation (UN IGME). Levels & trends in child mortality: report 2023. Estimates developed by the United Nations Inter-agency Group for Child Mortality Estimation. New York: UNICEF; 2024.
World Health Organization. Newborn mortality. Available at https://www.who.int/news-room/fact-sheets/detail/newborn-mortality. Accessed May 8, 2026.
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med 2018;6:223-230.
Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet 2016;388:3027-3035.
Wondifraw EB, Wudu MA, Tefera BD, Wondie KY. The burden of neonatal sepsis and its risk factors in Africa: a systematic review and meta-analysis. BMC Public Health 2025;25:847.
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Arch Dis Child 2021;106:745-752.
World Bank. Mortality rate, neonatal (per 1,000 live births) - Congo, Dem. Rep. Available at https://data.worldbank.org/indicator/SH.DYN.NMRT?locationCD. Accessed May 8, 2026.
United Nations Children’s Fund. Maternal and newborn health disparities: Democratic Republic of the Congo. Available at https://data.unicef.org/wp-content/uploads/country_profiles/Democratic%20Republic%20of%20the%20Congo/country%20profile_COD.pdf. Accessed May 8, 2026.
Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am 2013;60:367-389.
Schrag SJ, Farley MM, Petit S, Reingold A, Weston EJ, Pondo T, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics 2016;138:e20162013.
Giannoni E, Agyeman PKA, Stocker M, Posfay-Barbe KM, Heininger U, Spycher BD, et al. Neonatal sepsis of early onset, and hospital-acquired and community-acquired late onset: a prospective population-based cohort study. J Pediatr 2018;201:106-14.e4.
Stoll BJ, Puopolo KM, Hansen NI, Sanchez PJ, Bell EF, Carlo WA, et al. Early-onset neonatal sepsis 2015 to 2017, the rise of Escherichia coli, and the need for novel prevention strategies. JAMA Pediatr 2020;174:e200593.
World Health Organization. Managing possible serious bacterial infection in young infants when referral is not feasible. Geneva: WHO; 2015.
World Health Organization. Pocket book of hospital care for children: guidelines for the management of common childhood illnesses. 2nd ed. Geneva: WHO; 2013.
National Institute for Health and Care Excellence. Neonatal infection: antibiotics for prevention and treatment (NG195). Available at https://www.nice.org.uk/guidance/ng195. Accessed May 8, 2026.
Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, editors. Red Book: 2021-2024 report of the Committee on Infectious Diseases. 32nd ed. Itasca, IL: American Academy of Pediatrics; 2021.
Kariniotaki C, Thomou C, Gkentzi D, Panteris E, Dimitriou G, Hatzidaki E. Neonatal sepsis: a comprehensive review. Antibiotics (Basel) 2025;14:6.
Okomo U, Akpalu ENK, Le Doare K, Roca A, Cousens S, Jarde A, et al. Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines. Lancet Infect Dis 2019;19:1219-1234.
Sands K, Carvalho MJ, Portal E, Thomson K, Dyer C, Akpulu C, et al. Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries. Nat Microbiol 2021;6:512-523.
Blumenroder S, Wilson D, Ndaboine E, Mirambo MM, Mushi MF, Bader O, et al. Neonatal infection in Sub-Saharan Africa: a cross-sectional pilot study on bacterial pathogens and maternal risk factors. Front Microbiol 2023;14:1171651.
Guo L, Han W, Su Y, Wang N, Chen X, Ma J, et al. Perinatal risk factors for neonatal early-onset sepsis: a meta-analysis of observational studies. J Matern Fetal Neonatal Med 2023;36:2259049.
Mulinganya GM, Claeys M, Balolebwami SZ, Bamuleke BA, Mongane JI, Boelens J, et al. Etiology of early-onset neonatal sepsis and antibiotic resistance in Bukavu, Democratic Republic of the Congo. Clin Infect Dis 2021;73:e976-e980.
Nebbioso A, Ogundipe OF, Repetto EC, Mekiedje C, Sanke-Waigana H, Ngaya G, et al. When first line treatment of neonatal infection is not enough: blood culture and resistance patterns in neonates requiring second line antibiotic therapy in Bangui, Central African Republic. BMC Pediatr 2021;21:570.
Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 33rd ed. CLSI supplement M100. Wayne, PA: Clinical and Laboratory Standards Institute; 2023.
European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 13.0; 2023. Available at https://www.eucast.org/bacteria/clinical-breakpoints-and-interpretation/clinical-breakpoint-tables/. Accessed May 8, 2026.
Dik JW, Poelman R, Friedrich AW, Panday PN, Lo-Ten-Foe JR, van Assen S, et al. An integrated stewardship model: antimicrobial, infection prevention and diagnostic (AID). Future Microbiol 2016;11:93-102.
Dramowski A, Cotton MF, Whitelaw A, Meiring S, Quan V, Wadula J, et al. Neonatal sepsis in low- and middle-income countries: epidemiology, antimicrobial resistance and challenges in diagnosis and management. Clin Perinatol 2021;48:321-338.
Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev 2006;19:788-802.
Milton R, Gillespie D, Dyer C, Taiyari K, Carvalho MJ, Thomson K, et al. Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. Lancet Glob Health 2022;10:e661-e672.
Calkavur S, Kalkanli OH, Ketenci T, Kavas N, Yilmaz Celebi M, Bayram A, et al. Effectiveness of a blood culture bundle in reducing contamination rates in a neonatal intensive care unit. Turk J Pediatr 2025;67:135-143.
Fuchs A, Bielicki J, Mathur S, Sharland M, Van Den Anker JN. Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children. Paediatr Int Child Health 2018;38(Suppl 1:S3-15.
