Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines. - 2024
Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines.
Sørensen, T M; Scahill, K; Ruperez, J Espinelet al.
Antimicrobial stewardship; Cats; Dogs; Peri-operative; SAP; SSI; Surgical Site Infection; Anti-Bacterial Agents; Animals; Cats/surgery; Pets; Practice Guidelines as Topic; Cat Diseases/prevention & control; Cat Diseases/drug therapy; Cat Diseases/surgery; Anti-Bacterial Agents/therapeutic use; Anti-Bacterial Agents/administration & dosage; Europe; Dog Diseases/prevention & control; Dog Diseases/surgery; Dog Diseases/drug therapy; Antimicrobial Stewardship; Surgical Wound Infection/veterinary; Surgical Wound Infection/prevention & control; Antibiotic Prophylaxis/veterinary; Anti-Infective Agents; Antibiotic Prophylaxis; Cat Diseases; Dog Diseases; Humans; Surgical Wound Infection; Animal Science and Zoology; Veterinary (all)
Abstract :
[en] Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is. Therefore, it is difficult for surgeons to properly weigh the costs, risks and benefits for individual patients when deciding on the use of SAP, making it challenging to promote antimicrobial stewardship in primary practice settings. The objective of this study was to map the veterinary evidence focused on assessing the effect of SAP on SSI development and in order to identify surgical procedures with some research evidence and possible knowledge gaps. In October 2021 and December 2022, Scopus, CAB Abstracts, Web of Science Core Collection, Embase and MEDLINE were systematically searched. Double blinded screening of records was performed to identify studies in companion animals that reported on the use of SAP and SSI rates. Comparative data were available from 34 out of 39123 records screened including: eight randomised controlled trials (RCT), 23 cohort studies (seven prospective and 16 retrospective) and three retrospective case series representing 12476 dogs and cats in total. Extracted data described peri- or post-operative SAP in nine, and 25 studies, respectively. In the eight RCTs evaluating SAP in companion animals, surgical procedure coverage was skewed towards orthopaedic stifle surgeries in referral settings and there was large variation in SAP protocols, SSI definitions and follow-up periods. More standardized data collection and agreement of SSI definitions is needed to build stronger evidence for optimized patient care.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Sørensen, T M; Department of Veterinary Clinical Sciences, University of Copenhagen, Dyrlaegevej 16, Frederiksberg C 1870, Denmark, ESCMID Study Group for Veterinary Microbiology (ESGVM), Basel, Switzerland. Electronic address: tims@sund.ku.dk
Scahill, K; College of Medicine and Veterinary Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom, Evidensia Södra Djursjukhuset Kungens Kurva, Månskärarvägen 13, Kungens Kurva 14175, Sweden, ESCMID Study Group for Veterinary Microbiology (ESGVM), Basel, Switzerland
Ruperez, J Espinel; College of Veterinary Medicine, Murdoch University, Murdoch, Perth, WA 6150, Australia
Olejnik, M; Department of Fundamental and Preclinical Sciences, Nicolaus Copernicus University, Jurija Gagarina 11, Toruń 87-100, Poland
Swinbourne, F; Lumbry Park Veterinary Specialists, Selborne Rd, Alton GU34 3HL, United Kingdom
Verwilghen, D R; Sydney School of Veterinary Science, University of Sydney, Regimental Dr, Camperdown, NSW 2050, Australia
Nolff, M C; Clinic for Small Animal Surgery, Vetsuisse Faculty, University Zürich, Winterthurerstrasse 260, TFA 01.51, Zürich 8057, Switzerland
Baines, S; Willows Veterinary Centre & Referral Service, Solihull B90 4NH, United Kingdom
Marques, C; Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisboa 1749-024, Portugal, Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Tapada da Ajuda, Lisboa, Portugal
Duarte, E L; Mediterranean Institute for Agriculture, Environment and Development & Departamento de Medicina Veterinária, Escola de Ciências e Tecnologia, Universidade de Évora, Universidade de Évora, Pólo da Mitra Apartado 94, Évora 7006-554, Portugal, ESCMID Study Group for Veterinary Microbiology (ESGVM), Basel, Switzerland
Dias, M; Mediterranean Institute for Agriculture, Environment and Development & Departamento de Medicina Veterinária, Escola de Ciências e Tecnologia, Universidade de Évora, Universidade de Évora, Pólo da Mitra Apartado 94, Évora 7006-554, Portugal
Dewulf, Suzanne ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire ; Veterinary Epidemiology Unit, Faculty of Veterinary Medicine, Ghent University, Gebouw D4, Salisburylaan 133, Merelbeke, Ghent 9820, Belgium
Wichtowska, A; Department of Fundamental and Preclinical Sciences, Nicolaus Copernicus University, Jurija Gagarina 11, Toruń 87-100, Poland
Valencia, A Carranza; Department of Clinical Veterinary Medicine, Vetsuisse Faculty, Bern University, Länggassstrasse 120, Bern 3012, Switzerland
Pelligand, L; Dept. Comparative Biomedical Sciences, The Royal Veterinary College, University of London, 4 Royal College St, London NW1 0TU, United Kingdom, ESCMID Study Group for Veterinary Microbiology (ESGVM), Basel, Switzerland
Broens, E M; Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht 3584 CL, the Netherlands, ESCMID Study Group for Veterinary Microbiology (ESGVM), Basel, Switzerland
Toutain, P L; Dept. Comparative Biomedical Sciences, The Royal Veterinary College, University of London, 4 Royal College St, London NW1 0TU, United Kingdom, INTHERES, Université de Toulouse, INRAE, ENVT, 23 Chem. des Capelles Entrée n°1, Toulouse 31300, France
Alishani, M; Department of Veterinary Medicine, Faculty of Agriculture and Veterinary, University of Prishtina "Hasan Prishtina", Prishtina 10 000, Kosovo
Brennan, M L; Centre for Evidence-based Veterinary Medicine, The University of Nottingham, Loughborough LE12 5RD, United Kingdom
Weese, J S; Dept of Pathobiology, Ontario Veterinary College, University of Guelph, 419 Gordon St, Guelph, ON N1G 2W1, Canada
Jessen, L R; Department of Veterinary Clinical Sciences, University of Copenhagen, Dyrlaegevej 16, Frederiksberg C 1870, Denmark, ESCMID Study Group for Veterinary Microbiology (ESGVM), Basel, Switzerland
Allerton, F; Willows Veterinary Centre & Referral Service, Solihull B90 4NH, United Kingdom
from European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines and theESCMID Study Group for Veterinary Microbiology (ESGVM)
Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines.
UCPH - Københavns Universitet COST - European Cooperation in Science and Technology
Funding text :
We wish to thank information specialist Anne Cathrine Trumpy, University of Copenhagen, for the constructive discussions on our search strategy. The published protocol is available at https://sid.erda.dk/share_redirect/HAR2r8D8mN.
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