biomarkers; cultural considerations; diagnosis; language assessment; neurodegenerative diseases; primary progressive aphasia; Aging; Cognitive Neuroscience
Abstract :
[en] Primary progressive aphasia (PPA) is a clinical syndrome characterized by the progressive decline of language abilities due to neurodegenerative disease. Accurate and timely diagnosis is critical for effective clinical management, patient support, and research participation. However, several diagnostic challenges persist, including limitations in current syndromic classifications, lack of linguistically and culturally standardized assessment tools, overlap with other neurocognitive disorders, heterogeneity in underlying pathology, limited biomarker specificity, and unequal access to specialized care. This article reviews key diagnostic barriers and proposes future directions to improve the clinical identification and classification of PPA, with an emphasis on cross-linguistic and cross-cultural considerations.
Disciplines :
Speech and language therapy
Author, co-author :
Macoir, Joël; Faculté de Médecine, École des Sciences de la Réadaptation, Université Laval, Québec, QC, Canada ; Centre de Recherche CERVO-Brain Research Centre, Québec, QC, Canada
Lavoie, Monica; Chaire de Recherche sur les Aphasies Primaires Progressives - Fondation de la Famille Lemaire, Québec, QC, Canada
Duboisdindien, Guillaume ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; Laboratoire LINC, UMR 1322 INSERM, UFR Sciences de la Santé, Université Marie and Louis Pasteur, Besançon, France
Laforce, Robert; Chaire de Recherche sur les Aphasies Primaires Progressives - Fondation de la Famille Lemaire, Québec, QC, Canada ; Département des Sciences Neurologiques, Clinique Interdisciplinaire de Mémoire (CIME) du CHU de Québec, Québec, QC, Canada
Language :
English
Title :
Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions.
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