Humans; Aging/pathology/physiology; Brain/pathology/physiology; Female; Aged; Exposome; Male; Alzheimer Disease/physiopathology/pathology/epidemiology; Cognitive Dysfunction/physiopathology/pathology; Middle Aged; Cross-Sectional Studies; Aged, 80 and over
Abstract :
[en] The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse settings globally and their associations with brain aging. In this study, we characterized the associations between 73 country-level physical and social exposomal factors and multimodal brain age in 18,701 participants from 34 countries (healthy individuals and those with Alzheimer's disease, frontotemporal lobar degeneration or mild cognitive impairment). Exposome effects were assessed using generalized additive models and meta-analytic frameworks. Aggregated exposome models explained up to 15.5-fold more variance than individual exposures (delta Akaike information criterion (ΔAIC): 2,034-3,127). Physical exposome was primarily associated with accelerated structural brain aging (limbic, subcortical and cerebellar regions), whereas social exposome was more strongly associated with functional brain aging (frontotemporal and limbic networks). Exposome burden accounted for 3.3-9.1-fold higher risk of accelerated aging, exceeding effects of clinical diagnoses. Findings were out-of-sample validated in cross-sectional and longitudinal designs, remained consistent across clinical subgroups and persisted after adjustment for demographics, age correction bias, cognition, scanner type and data quality. The exposome accelerates brain aging in health and disease, underscoring the need to address physical, social and political inequities.
Disciplines :
Neurosciences & behavior
Author, co-author :
Legaz, Agustina; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina. ; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA.
Moguilner, Sebastian; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina.
Barttfeld, Pablo; Cognitive Science Group, Instituto de Investigaciones Psicológicas (IIPsi, CONICET-UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina.
Cuadros Castro, Jhosmary; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Advanced Center for Electrical and Electronic Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile. ; Grupo de Bioingeniería, Decanato de Investigación, Universidad Nacional Experimental del Táchira, San Cristóbal, Venezuela.
Galván Rial, Dante Sebastián; Cognitive Science Group, Instituto de Investigaciones Psicológicas (IIPsi, CONICET-UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina.
Migeot, Joaquin; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), Francisco, CA, USA. ; Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland.
Farina, Francesca R; Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA. ; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Gonzalez-Gomez, Raul ; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Neurology and Neurosurgery Department, Montreal Neurological Institute, Montreal, Quebec, Canada.
Salazar-Londoño, Salomón ; Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
de Souza Azzi, Tiago ; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Alcauter, Sarael; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.
Amoruso, Lucia; Basque Center on Cognition, Brain and Language (BCBL), San Sebastian, Spain. ; Cognitive Neuroscience Center, University of San Andrés, Buenos Aires, Argentina. ; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Anghinah, Renato; Departament of Neurology of Medical School, University of São Paulo, São Paulo, Brazil.
Bakr, May ; Institute of Global Health and Human Ecology (IGHHE), The American University in Cairo (AUC), New Cairo, Egypt.
Behrens, María Isabel ; Centro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile, Santiago, Chile. ; Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago, Chile. ; Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile. ; Departamento de Neurología y Psiquiatría, Clínica Alemana - Universidad del Desarrollo, Santiago, Chile.
Bruno, Martin A; Instituto Ciencias Biomedicas (ICBM), Facultad Ciencias Medicas, Universidad Catolica de Cuyo, San Juan, Argentina. ; National Council on Scientific and Technical Research (CONICET), Buenos Aires, Argentina.
Cardona, Juan Felipe; Faculty of Psychology, Universidad del Valle, Cali, Colombia.
Chen, Christopher ; Memory, Ageing and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Colliot, Olivier; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm U1127, CNRS UMR 7225, Paris, France.
Custodio, Nilton; Unidad de diagnóstico de deterioro cognitivo y prevención de demencia, Instituto Peruano de Neurociencias, Lima, Perú.
d'Acremont, Quentin; Bordeaux Population Health, U1219, INSERM, University of Bordeaux, Bordeaux, France.
Debette, Stéphanie ; Bordeaux Population Health, U1219, INSERM, University of Bordeaux, Bordeaux, France. ; Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France.
Dzianok, Patrycja ; Laboratory of Emotions Neurobiology, Center of Excellence for Neural Plasticity and Brain Disorders BRAINCITY, Nencki Institute of Experimental Biology PAS, Warsaw, Poland. ; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.
Güntekin, Bahar; Research Institute for Health Sciences and Technologies (SABITA), Neuroscience Research Center Istanbul Medipol University, İstanbul, Türkiye. ; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Türkiye.
Huguet, Jordi ; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Jarne, Cecilia ; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; National Council on Scientific and Technical Research (CONICET), Buenos Aires, Argentina. ; Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes (UNQ), Bernal, Argentina. ; Department of Clinical Medicine, Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Joliot, Marc ; Institute of Neurodegenerative Diseases (IMN), UMR5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.
Karageorgiou, Elissaios ; Sleep & Memory Center, Neurological Institute of Athens, Athens, Greece.
Khedr, Eman M; Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt.
Koopowitz, Sheri-Michelle; Department of Psychiatry, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Kublik, Ewa ; Laboratory of Emotions Neurobiology, Center of Excellence for Neural Plasticity and Brain Disorders BRAINCITY, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
Lee, Jinkook ; Department of Economics, University of Southern California, Los Angeles, CA, USA. ; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Aksman, Leon ; Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lopez, Susanna; Department of Physiology and Pharmacology 'Erspamer', Sapienza University of Rome, Rome, Italy.
Margaretic, Paula; Faculty of Business and Economics, University of Chile, Santiago de Chile, Chile. ; Business school, University of San Andres, Buenos Aires, Argentina.
Matallana, Diana; Centro de Memoria y Cognición, Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia. ; Departamento de Salud Mental, Hospital Universitario Santa Fe de Bogotá, Bogotá, Colombia. ; Pontifica Universidad Javeriana, Instituto de Envejecimiento, Bogotá, Colombia.
Matis, Sophie; School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. ; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Miltiadous, Andreas ; Department of Informatics & Telecommunications, School of Informatics & Telecommunications, University of Ioannina Kostakioi, Arta, Greece.
Novotni, Gabriela ; Department of Cognitive Neurology and Neurodegenerative Diseases, University Clinic of Neurology, Skopje, North Macedonia. ; Medical Faculty, University 'Ss Cyril and Methodius', Skopje, North Macedonia.
Orio, Patricio ; Advanced Center for Electrical and Electronic Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile. ; Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile. ; Centro Interdisciplinario de Neurociencia de Valparaíso, Valparaíso, Chile.
Parra, Mario A; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.
Reppermund, Simone; Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
de Paula França Resende, Elisa; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. ; Departamento de Clínica Médica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. ; Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil.
Salum, Giovanni Abrahão; Department of Psychiatry, Universidade Federal do Rio Grande do Sul - Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. ; Global Programs, Child Mind Institute, New York, NY, USA. ; Center for Research and Innovation in Mental Health, Universidade de São Paulo, São Paulo, Brazil.
Slachevsky, Andrea; Departamento de Neurología y Psiquiatría, Clínica Alemana - Universidad del Desarrollo, Santiago, Chile. ; Centro Gerociencias, Salud Mental y Metabolismo (GERO), Santiago, Chile. ; Laboratorio de Neuropsicología y Neurociencias Clínicas (LANNEC) Programa de Fisiopatología - ICBM, Departamento de Ciencias Neurológicas Oriente y Neurociencias, Facultad de Medicina, Universidad de Chile, Santiago, Chile. ; Centro de Memoria y Neuropsiquiatría (CMYN), Servicio de Neurología, Hospital del Salvador y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Ortiz, Ana Luisa Sosa; Laboratorio de demencias, Instituto Nacional de Neurología y Neurocirugía, MVS, Mexico City, Mexico.
Takada, Leonel Tadao ; Department of Neurology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Toh, An Qi ; Memory, Ageing and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Tzallas, Alexandros ; Department of Informatics & Telecommunications, School of Informatics & Telecommunications, University of Ioannina Kostakioi, Arta, Greece.
Wen, Wei ; Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Whelan, Robert; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; School of Psychology, Trinity College Dublin, Dublin, Ireland.
Yener, Görsev ; Department of Neurology, Dokuz Eylül University, Izmir, Türkiye.
Zegarra Valdivia, Jonathan Adrián ; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. ; Laboratory of Neurobiology of Insulin Peptides, Achucarro Basque Center for Neuroscience, Bilbao, Spain. ; Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid, Madrid, Spain.
Alexoudi, Athanasia; Neurological Institute of Athens, Athens, Greece. ; Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece. ; First Department of Neurosurgery, Evangelismos Athens General Hospital, Athens, Greece.
Arshad, Faheem; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. ; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Atta, Haisam; South Egypt Cancer Institute, Assiut, Egypt.
Avila-Funes, Jose Alberto; Bordeaux Population Health, U1219, INSERM, University of Bordeaux, Bordeaux, France. ; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Santos, Jasmin Bonilla ; Department of Psychology, Universidad Cooperativa de Colombia, Neiva, Colombia.
Bruña, Ricardo; Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid, Madrid, Spain. ; Department of Radiology, Rehabilitation, and Physiotherapy, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain. ; Institute of Sanitary Investigation (IdISSC), San Carlos University Hospital, Madrid, Spain.
Castelblanco-Toro, Sandra Milena; Institute of Aging of the Faculty of Medicine of the Pontificia Universidad Javeriana, Bogotá, Colombia. ; Department of Psychiatry, Pontificia Universidad Javeriana, Bogotá, Colombia. ; Intellectus Memory and Cognition Center, San Ignacio University Hospital, Bogotá, Colombia.
Chino Vilca, Brenda Nadia ; Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid, Madrid, Spain. ; Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain. ; Achucarro Basque Center for Neuroscience, Leioa, Spain.
Coronel-Oliveros, Carlos; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), Francisco, CA, USA. ; Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland. ; Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Crivello, Fabrice ; Institute of Neurodegenerative Diseases (IMN), UMR5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.
Cruzat, Josephine; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Dellavale, Damián ; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro Atómico Bariloche, San Carlos de Bariloche, Río Negro, Argentina.
Dhooge, Catherina; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina.
Di Caterina, Gaetano; Electronic and Electrical Engineering Department, University of Strathclyde, Glasgow, UK.
Escudero, Javier ; School of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Edinburgh, UK.
Esquivias Farias, Juan Manuel ; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México. ; Centro Universitario de la Ciénega, Universidad de Guadalajara, Jalisco, Mexico.
Eze, Laz Ude ; Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), Francisco, CA, USA. ; Department of Public Health, David Umahi Federal University of Health Sciences, Uburu, Nigeria. ; Sub-Saharan Africa Brain Health Initiative, Abuja, Nigeria.
Evans, Tavia E; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. ; Department of Human Genetics, Radbound UMC, Nijmegen, The Netherlands.
Farombi, Temitope; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; Neurology unit, Chief Tony Anenih, Geriatric Center, University College Hospital, Ibadan, Nigeria.
Fernández, Alberto; Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid, Madrid, Spain. ; Department of Legal Medicine, Psychiatry and Pathology, Complutense University of Madrid, Madrid, Spain.
Fittipaldi, Sol; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Portillo, Florencia ; National Council on Scientific and Technical Research (CONICET), Buenos Aires, Argentina. ; Instituto de Investigaciones en Psicología Básica y Aplicada, Universidad Católica de Cuyo, San Juan, Argentina.
Martinic, Gonzalo Forno ; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile. ; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - ICBM, Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile.
García, Adolfo M ; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina. ; Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), Francisco, CA, USA. ; Departamento de Lingüística y Literatura, Facultad de Humanidades, Universidad de Santiago de Chile, Santiago, Chile.
Garcia-Cordero, Indira; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina.
Gaurav, Rahul; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm U1127, CNRS UMR 7225, Paris, France. ; Movement Investigations and Therapeutics - MOV'IT, Paris Brain Institute, Paris, France. ; Center for NeuroImaging Research - CENIR, Paris Brain Institute, Paris, France.
Godoy, Maria Eugenia; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina.
Gonzalez Campo, Cecilia; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina. ; National Council on Scientific and Technical Research (CONICET), Buenos Aires, Argentina.
González Hernández, Alfredis; Department of Psychology, Master Program of Clinical Neuropsychology, Universidad Surcolombiana Neiva, Huila, Colombia.
Hanoğlu, Lütfü; Research Institute for Health Sciences and Technologies (SABITA), Neuroscience Research Center Istanbul Medipol University, İstanbul, Türkiye. ; Department of Neurology, İstanbul Medipol University, Istanbul, Türkiye. ; Regenerative and Restorative Medicine Research Center (REMER), Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Türkiye.
Hazelton, Jessica L; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. ; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Herzog, Rubén; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Mallorca, Spain.
Ikiz, Burcin; Neuro Climate Working Group, Global Consortium on Climate and Health Education, Columbia University, New York, NY, USA.
Njamnshi, Alfred Kongnyu ; Department of Translational Neuroscience, Brain Research Africa Initiative (BRAIN), Geneva, Switzerland. ; Department of Translational Neuroscience, Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon. ; Neuroscience Lab, FMBS, The University of Yaoundé I, Yaoundé, Cameroon. ; Department of Neurology, Yaoundé Central Hospital, Yaoundé, Cameroon.
Landin-Romero, Ramon; School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. ; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
López, María Eugenia ; Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid, Madrid, Spain. ; Institute of Sanitary Investigation (IdISSC), San Carlos University Hospital, Madrid, Spain. ; Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, Spain.
Maito, Marcelo Adrián; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina.
Medel, Vicente; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Sepúlveda, Juan Pablo Morales; University of Sydney Business School, Darlington, New South Wales, Australia. ; Facultad de Educación Psicología y Familia, Universidad Finis Terrae, Santiago, Chile.
Ochoa Gómez, John Fredy; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Ogbuagu, Chukwuanugo; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. ; Community Medicine and Primary Health Care, Nnamdi Azikiwe University Teaching Hospital, Neni, Nigeria.
de Oliveira, Maira Okada; Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), Francisco, CA, USA. ; Department of Neurology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Ozansoy, Mehmet ; Department of Physiology, Istanbul Medipol University, International School of Medicine, Istanbul, Türkiye.
Palma-Espinosa, Javier; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; Centro Interdisciplinario de Neurociencia de Valparaíso, Valparaíso, Chile.
Hilal, Saima; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Zhou, Juan Helen ; 3Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ; Healthy Longevity & Human Potential Translational Research Programme and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ; Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.
Escudero, Stefanie Danielle Piña; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. ; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Pitman, Julie Kay; Sleep & Memory Center, Neurological Institute of Athens, Athens, Greece.
Prado, Pavel ; Escuela de Fonoaudiología, Facultad de Ciencias de la Rehabilitación y Calidad de Vida, Universidad San Sebastián, Santiago de Chile, Chile.
Ramírez González, Diego; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.
Reyes, Pablo ; PhD Program of Neuroscience, Psychiatry and Mental Health Department, Pontificia Universidad Javeriana, Bogota, Colombia. ; Research Office, Hospital Universitario San Ignacio, Bogota, Colombia.
Santamaría García, Hernando ; Centro de Memoria y Cognición Intellectus, Hospital Universitario San Ignacio, Bogota, Colombia. ; Universidad Javeriana PhD Program of Neuroscience, Bogotá, Colombia. ; Laboratory of Cognition, Neurosciences, and Context. Department of Psychiatry, Universidad Javeriana, Bogotá, Colombia.
Schröder, Johannes; Section of Geriatric Psychiatry, University of Heidelberg, Heidelberg, Germany.
Sitt, Jacobo Diego; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm U1127, CNRS UMR 7225, Paris, France.
Soliman, Radwa Kamel ; Department of Diagnostic and Interventional Radiology Faculty of Medicine, Assiut University, Asyut, Egypt.
Soto-Añari, Marcio ; Laboratorio de Neurociencia Cognitiva, Universidad Católica San Pablo, Arequipa, Peru.
Thanissery, Nithin; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Ito, Lucas Toshio ; Department of Biochemistry, Universidade Federal de São Paulo, São Paulo, Brazil. ; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo, São Paulo, Brazil.
Tsuchida, Ami ; Bordeaux Population Health, U1219, INSERM, University of Bordeaux, Bordeaux, France. ; Institute of Neurodegenerative Diseases (IMN), UMR5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.
Tzourio, Christophe ; Bordeaux Population Health, U1219, INSERM, University of Bordeaux, Bordeaux, France. ; Bordeaux University Hospital Center (CHU Bordeaux), Bordeaux, France.
Yırıkoğulları, Harun ; Research Institute for Health Sciences and Technologies (SABITA), Neuroscience Research Center Istanbul Medipol University, İstanbul, Türkiye. ; Program of Electroneurophysiology, Vocational School, Istanbul Medipol University, Istanbul, Türkiye.
Yokoyama, Jennifer S ; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. ; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Aguillon, David ; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Miller, Bruce; Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), Francisco, CA, USA. ; Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland. ; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Alladi, Suvarna; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Jiang, Yang ; Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY, USA. ; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
Navarro, Arcadi; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. ; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, Barcelona, Spain. ; IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. ; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Babiloni, Claudio; Department of Physiology and Pharmacology 'Erspamer', Sapienza University of Rome, Rome, Italy. ; Hospital San Raffaele Cassino, Cassino, Italy.
Huepe Artigas, David; Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez, Santiago de Chile, Chile.
Piguet, Olivier ; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia. ; School of Psychology, The University of Sydney, Sydney, New South Wales, Australia.
Sosa, Pedro Antonio Valdes ; Joint Cuba China Laboratory for Neurotechnology, University of Electronic Scicene and Technology of China, Chengdu, China. ; Department of Neurophysics, Cuban Center for Neuroscience, Havana, Cuba.
Mostert, Cyprian M; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; Brain and Mind Institute, Aga Khan University, Nairobi, Kenya. ; Department of Population Health, Aga Khan University, Nairobi, Kenya. ; Euro-Mediterranean Economists Association, Barcelona, Spain.
Tahmasian, Masoud ; Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany. ; Institute for Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. ; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Li, Peng ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA. ; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Hu, Kun; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. ; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Genon, Sarah ; Université de Liège - ULiège > Département des sciences cliniques ; Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany. ; Institute for Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Stein, Dan J ; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, Cape Town, South Africa.
Maestú, Fernando ; Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid, Madrid, Spain. ; Institute of Sanitary Investigation (IdISSC), San Carlos University Hospital, Madrid, Spain. ; Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, Spain.
Pievani, Michela ; Lab Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Salama, Mohamed ; Institute of Global Health and Human Ecology (IGHHE), The American University in Cairo (AUC), New Cairo, Egypt.
Brodaty, Henry ; Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia. ; Older Persons' Mental Health Service, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Sachdev, Perminder S ; Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia. ; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Lawlor, Brian; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Eyre, Harris A ; Global Brain Economy Initiative, Office of Innovation, Rice University, Houston, TX, USA. ; Department of Psychiatry, School of Medicine, The University of Texas Medical Branch (UTMB), Galveston, TX, USA. ; Neuro-Policy Program, Center for Health, Baker Institute for Public Policy, Rice University, Houston, TX, USA. ; Brain Economy Initiative, Office of Innovation, Rice University, Houston, TX, USA. ; Neuro-Engineering Initiative (NEI), School of Engineering, Rice University, Houston, TX, USA. ; Department of Psychological Sciences, School of Social Sciences, Rice University, Houston, TX, USA.
Miranda, J Jaime ; Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. ; CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Baez, Sandra ; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. ; Universidad de los Andes, Bogota, Colombia.
Tagliazucchi, Enzo; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. ; University of Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Física, CONICET, Buenos Aires, Argentina.
Duran-Aniotz, Claudia; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Hernandez, Hernan ; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. hernan.hernandez.l@uai.cl.
Ibanez, Agustin ; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. agustin.ibanez@gbhi.org. ; Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andres, Buenos Aires, Argentina. agustin.ibanez@gbhi.org. ; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. agustin.ibanez@gbhi.org. ; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Türkiye. agustin.ibanez@gbhi.org. ; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. agustin.ibanez@gbhi.org.
R01 AG057234/AG/NIA NIH HHS/United States; S10OD032285, R01AG080473, RF1AG087965 and RF1AG088003/U.S. Department of Health & Human Services; National Institutes of Health (NIH)/; R01AG051125, U01AG064948/U.S. Department of Health & Human Services; NIH; National Institute on Aging (U.S. National Institute on Aging)/
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