[en] Zinc is the second most prevalent biometal found in the human body. Zn-based polymers have been gaining attention as anticancer drugs without interfering with the normal activites of cell lines. With this importance, we have synthesized Zn(II)-based 2D heterobridging coordination polymers, {[Zn(tdc)(bpms)(H2O)]n, (CP-1S)} and {[Zn(tdc)(bpds)(H2O)·2H2O]n, (CP-2S)} (tdc2-, 2,5-thiophene dicarboxylate; bpms, 4,4'-dipyridyl sulfide; and bpds, 4,4'-dipyridyl disulfide). The structures demonstrate that tdc2- bridges through monodentate coordination of carboxylate-O and (O, O)-chelation to neighboring Zn(II) centers to constitute the coordination polymer; bpms/bpds act as pyridyl-N connecting ligands and propagate almost perpendicular to the previous chain and design the 2D CPs. The materials emit in the blue region with fluorescence lifetimes of 6.08 ns (CP-1S) and 5.41 ns (CP-2S). The antiproliferative and apoptotic efficacies of the CPs have been studied in the presence of four cancer cell lines (human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), lung carcinoma epithelial cells (A549), and triple-negative breast cancer cells (MDA-MB-231)) and have been compared with the standard anticancer drug, i.e., cisplatin. The CPs are not cytotoxic to the human fetal lung fibroblast cell line (WI-38), and the highest anticancer efficiency is observed against MCF-7 (IC50: 14.62 ± 1.49 (CP-1S) and 24.39 ± 1.23 μM (CP-2S) with reference to cisplatin (IC50, 6 μM). This study has a great deal of potential for the development of pharmaceuticals and provides an overview of the use of coordination polymers for medicinal purposes.
Disciplines :
Chemistry
Author, co-author :
Shit, Manik ; Department of Chemistry, Jadavpur University, Jadavpur, Kolkata 700032, India
Mahapatra, Manas ; Université de Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM)
Halder, Satyajit ; Division of Molecular Medicine, Bose Institute, EN 80, Sector V, Bidhan Nagar, Kolkata 700091, India
Samanta, Arnab; Department of Chemistry, Brainware University, Barasat, Kolkata 700125, India
Anas, Mahammad; Centre for Education and Research on Macromolecules (CERM), CESAM Research Unit, Department of Chemistry, University of Liege, Quartier Agora, Sart-Tilman, B6A, Liege 4000, Belgium
Jana, Kuladip; Division of Molecular Medicine, Bose Institute, EN 80, Sector V, Bidhan Nagar, Kolkata 700091, India
Sinha, Chittaranjan ; Department of Chemistry, Jadavpur University, Jadavpur, Kolkata 700032, India
Language :
English
Title :
Carboxylato-O and Pyridyl-N Hybrid Bridging Zn(II)-Based Two-Dimensional Fluorescent Coordination Polymers as Anticancer Drugs.
CSIR - Council of Scientific and Industrial Research
Funding text :
Funding from CSIR is gratefully acknowledged (Grant Number-01/3129/23/EMR-II). We are thankful to Jadavpur University for providing infrastructural support. Our sincere thanks to Dr. Basudeb Dutta (Department of Chemistry, School of Applied Sciences, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar-751024, Odisha) for helping us in structural analysis and insightful discussions. We also extend our gratitude to the Bose Institute, Kolkata, for providing instrumental facilities essential for conducting the biological studies.This study was funded by the Council of Scientific and Industrial Research (CSIR), India (Grant Number-01/3129/23/EMR-II).
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