Dental Implant Osseointegration Following Mandibular Augmentation Using 3D Printed Hydroxyapatite Blocks. An Experimental In Vivo Study.

Systermans, Simon; Ronsmans, Christophe; Nolens, Gregory; Meyns, Joeri; Gilon, Yves; Cobraiville, Elisabeth

doi:10.1111/clr.70056

Article (Scientific journals)

Dental Implant Osseointegration Following Mandibular Augmentation Using 3D Printed Hydroxyapatite Blocks. An Experimental In Vivo Study.

Systermans, Simon; Ronsmans, Christophe; Nolens, Gregory et al.

2025 • In Clinical Oral Implants Research, 37 (2), p. 101 - 113

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/346442

DOI
10.1111/clr.70056

PubMed
41074904

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Keywords :

3D printing; alveolar ridge augmentation; dental implants; guided bone regeneration; oral surgery; osseointegration; scaffold; tissue engineering; Durapatite; Dental Implants; Animals; Swine; Swine, Miniature; Female; Osseointegration/physiology; Printing, Three-Dimensional; Mandible/surgery; Dental Implantation, Endosseous/methods; Alveolar Ridge Augmentation/methods; Dental Implantation, Endosseous; Mandible

Abstract :

[en] [en] OBJECTIVE: To evaluate the use and osseointegration of dental implants in combination with 3D-printed hydroxyapatite (3DHA) blocks featuring gyroid porosity for large mandibular bone augmentation. METHODS: Mandibular lateral bone augmentation with gyroid-3DHA blocks was performed bilaterally on four female Göttingen minipigs. After 8 or 12 weeks of healing, a dental implant was placed into each 3DHA block. Following an additional 12-week healing period, the augmented sites (including 3DHA blocks and dental implants) were harvested for histological and histomorphometric analysis, assessing new bone formation, 3DHA integration, total bone gain, and bone-to-implant contact (BIC). RESULTS: Gyroid-3DHA blocks were easily fixated with screws. Dental implants were placed through the 3DHA blocks with a standard drilling procedure, and good primary stability was achieved. 3DHA blocks demonstrated good osseointegration with 39.17% of new bone and a significant bone gain of 4.73 mm on average. Dental implants showed comparable BIC within the 3DHA and into the native bone (42.79% vs. 34.17%). No significant difference was found between the healing periods. CONCLUSION: This is the first study to evaluate a 3D-printed bone substitute in combination with a dental implant in an animal study. Gyroid-3DHA blocks and dental implants demonstrated good osseointegration, and the bone augmentation was significant, making it a promising material for large and complex alveolar ridge augmentations.

Disciplines :

Dentistry & oral medicine
Surgery
Materials science & engineering

Author, co-author :

Systermans, Simon ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie plastique et maxillo-faciale

Ronsmans, Christophe ; Université de Liège - ULiège > Faculté de Médecine > Doct. scienc. médi. ; Department of Plastic, Esthetic and Reconstructive Surgery, CHR Citadelle Liège, Liège, Belgium

Nolens, Gregory ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique ; Faculty of Medicine, University of Namur, Namur, Belgium ; Cerhum SA, Liège, Belgium

Meyns, Joeri; Department of Oral and Maxillofacial Surgery, ZOL Genk, Genk, Belgium

Gilon, Yves ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie orale et maxillo-faciale

Cobraiville, Elisabeth ; Université de Liège - ULiège > Aérospatiale et Mécanique (A&M) ; Cerhum SA, Liège, Belgium

Language :

English

Title :

Dental Implant Osseointegration Following Mandibular Augmentation Using 3D Printed Hydroxyapatite Blocks. An Experimental In Vivo Study.

Publication date :

October 2025

Journal title :

Clinical Oral Implants Research

ISSN :

0905-7161

eISSN :

1600-0501

Publisher :

John Wiley and Sons Inc, Denmark

Volume :

Issue :

Pages :

101 - 113

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://onlinelibrary.wiley.com/doi/pdf/10.1111/clr.70056

Funders :

Gouvernement Wallon
ERDF - European Regional Development Fund

Funding number :

7931

Funding text :

Funding: This work was supported by the DOVIMIS project, co-funded by Cerhum and the European Union's FEDER \u201CWallonie 2020.EU\u201D program and the Walloon Region government under the program COOTECH MIX grant agreement No. 7931.

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