Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis.

[en] Bacteria-derived lipopeptides are immunogenic triggers of host defences in metazoans and plants. Root-associated rhizobacteria produce cyclic lipopeptides that activate induced systemic resistance against microbial infection in various plant species. Whether and how these molecules are perceived at the plant cell surface remains elusive. Here we reveal that immune activation in Arabidopsis thaliana by the lipopeptide elicitor surfactin is mediated via a specific interaction with membrane sphingolipids. It relies on host membrane remodelling and subsequent activation of mechanosensitive ion channels. This mechanism leads to host defence potentiation and resistance to the necrotrophic fungus Botrytis cinerea and appears distinct from pattern-triggered immunity induced by classical host pattern recognition receptors. These results reveal a previously uncharacterized mechanism through which lipopeptides derived from non-pathogenic bacteria activate plant immune responses.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Gilliard, Guillaume ^✱; Université de Liège - ULiège > Département GxABT > Chemistry for Sustainable Food and Environmental Systems (CSFES) ; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Segrate, Italy ; Unité de Génie Enzymatique et Cellulaire, University of Picardie Jules Verne, Amiens, France

Prsic, Jelena ^✱; Université de Liège - ULiège > TERRA Research Centre

Crowet, Jean-Marc ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chemistry for Sustainable Food and Environmental Systems (CSFES) ; MAgICS, MEDyC, CNRS UMR 7369 UFR Sciences Exactes et Naturelles, University of Reims Champagne-Ardenne, Reims, France

Chemotti, Catherine ; Université de Liège - ULiège > Département GxABT > Chemistry for Sustainable Food and Environmental Systems (CSFES)

Ahmed, Jahed; Laboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France

Lorent, Joseph ; Cellular and Molecular Pharmacology, Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium

Jolivet, Marie-Dominique; Plant Cell Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany

Egli, Sabrina ; Institute of Cell and Interaction Biology, CEPLAS Cluster of Excellence on Plant Sciences, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

Egée, Stéphane ; UMR8227 LBI2M Sorbonne Université-CNRS, Station Biologique de Roscoff, Roscoff, France

Bouyer, Guillaume ; UMR8227 LBI2M Sorbonne Université-CNRS, Station Biologique de Roscoff, Roscoff, France

More authors (36 more)

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis.

Publication date :

20 April 2026

Journal title :

Nature Plants

eISSN :

2055-0278

Publisher :

Nature Research, England

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.nature.com/articles/s41477-026-02270-3.pdf

Available on ORBi :

since 14 June 2026

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