[en] Sirtuin 1 (SIRT1) plays a central role in the circadian transcription of several core clock genes in a nicotinamide adenine dinucleotide (NAD+) dependant manner, thus linking cell metabolism to sleep-wakefulness regulation. Studies in animals and human suggest a bidirectional interaction between circadian rhythmicity and sleep homeostasis. However,
the molecular mechanisms underpinning this interplay remain poorly understood. We
hypothesize that sleep need is driven by the energetic cost of cellular metabolism, with
clock genes acting as energy sensors. Therefore, variants in key genes that are both
regulated by cellular metabolism and modulate clock activity may influence sleep homeostasis. We assessed the association between slow wave energy (SWE), a validated and highly heritable metric for sleep pressure dissipation during slow wave sleep, and a SIRT1 haplotype in a large cohort.
Research Center/Unit :
GIGA-SLEEP - GIGA CRC In vivo Imaging-Sleep and chronobiology - ULiège
