[en] [en] BACKGROUND: Primary immune thrombocytopenia (ITP) in cats is rare. Evidence is lacking on effective immunosuppressive protocols, prognosis, and prognostic indicators.
HYPOTHESIS/OBJECTIVES: To investigate immunosuppressive treatment outcomes and prognostic indicators of cats with primary ITP.
ANIMALS: Thirty-one cats with primary ITP.
METHODS: Multi-institutional retrospective cohort study (2000-2023). Cats were identified by searching medical records from 12 institutions. Immunosuppressive treatments and prognostic indicators were studied in association with clinical outcomes. Indicators included age, sex, breed, bodyweight, initial platelet count and PCV, blood urea nitrogen concentration, and blood product administration. Outcomes including medical control (platelet count > 57 000/μL), relapse, remission, death, and survival to discharge were analyzed using logistic regression models. Hospitalization duration, days to medical control, remission, and death were assessed using linear regression models. Survival was assessed using the Kaplan-Meier method.
RESULTS: Of the cats included, 27/31 (87%) survived to discharge, 25/31 (81%) achieved medical control, 8/25 (32%) achieved remission, 10/25 (40%) relapsed during immunosuppressive tapering, and 5/10 (50%) had a second relapse. Cats administered corticosteroids and cyclosporine had longer hospitalizations than corticosteroids alone (8.4 ± 0.9 vs 4.4 ± 0.9 days; P = .005). Median survival was not reached. Median follow-up was 315 days (95% CI, 216-1252).
CONCLUSIONS AND CLINICAL IMPORTANCE: Cats with primary ITP have a fair short-term prognosis and low remission rate. The frequent relapse rate warrants close monitoring. Besides longer hospitalization durations, combination immunosuppressive treatment did not affect other outcomes, when compared to corticosteroids alone.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Zhong, Mulan; Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales 2006, Australia
Hall, Evelyn; Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales 2006, Australia
Glanemann, Barbara; Queen Mother Hospital for Animals, The Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom
Jih, Susan H S; The Cat Clinic, Brisbane, Queensland, Australia
Korman, Rachel M; Veterinary Specialist Services, Brisbane, Queensland, Australia
Langhorn, Rebecca; Department of Veterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark
Leshinsky, Jana; Small Animal Specialist Hospital, Ryde, New South Wales, Australia
Lingard, Amy E; The Cat Doctors, Melbourne, Victoria, Australia
Roels, Elodie ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée
van Boeijen, Martine; Perth Cat Hospital, Perth, Western Australia, Australia
Boland, Lara A; Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales 2006, Australia ; Small Animal Specialist Hospital, Ryde, New South Wales, Australia
Language :
English
Title :
Treatment outcomes and prognostic indicators of primary immune thrombocytopenia in 31 cats: a multicenter retrospective study (2000-2023).
