[en] Tibetan sheep from different altitudes exhibit unique meat quality attributes, whereas the molecular mechanisms remain unelucidated. Such meat quality attributes are associated with underlying metabolic processes, which are influenced by high-altitude conditions. Herein, meat quality and muscle metabolism in Tibetan sheep from Oula (2900 m), Huoerba (4000 m), and Duoma (5100 m) were compared. Oula sheep showed higher moisture and lighter color, while Duoma sheep had the lowest fat content. A total of 419 differential metabolites were identified based on metabolomics. Among them, peptide contents decreased with increasing altitude of Tibetan sheep's residence, while carnitine derivatives increased. Bioinformatics analysis indicated that high altitude regulates HIF-1α signaling through hypoxic conditions and oxidative stress mediates glutathione oxidation, thus affecting meat L* value. This study reveals meat quality and the metabolic basis in Tibetan sheep at different altitudes, establishing a scientific foundation for resource utilization and development of Tibetan sheep at specific altitudes.
Disciplines :
Food science
Author, co-author :
Liu, Ruisi; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Fu, Jianing; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Li, Shaobo; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Gu, Minghui; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Li, Liang ; Université de Liège - ULiège > TERRA Research Centre ; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Xu, Le; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Yu, Jiangying; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Zhang, Dequan; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Chen, Li; Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Key Laboratory of Agro-Products Quality & Safety Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rural Affairs, Beijing 100193, China. Electronic address: chenliwork@126.com
Language :
English
Title :
Insight into the meat quality differences of Tibetan sheep from different altitudes based on metabolomics.
This work was supported by National Key Research and Development Program of China ( 2023YFD1600100 ) and Agriculture Research System of China of MOF and MARA ( CARS-38 ). We are deeply grateful to Chongxin Liu for his invaluable guidance and insightful advice throughout the revision of this manuscript.
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