Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review Aging Clinical and Experimental Research
Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review Aging Clinical and Experimental Research
[en] Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Buckinx, Fanny ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation
Rousseau, Anne-Françoise ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Louis, Edouard ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
De Roover, Arnaud ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endoctrinienne
Detry, Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
Durieux, Rodolphe ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie thoracique
Gillain, Sophie ; Université de Liège - ULiège > Département des sciences cliniques > Gériatrie
Kaba, Abdourahamane ; Université de Liège - ULiège > Département des sciences cliniques
Kaux, Jean-François ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Médecine physique, réadaptation et traumatologie du sport ; Department of Physical Medicine, Rehabilitation and Sports Traumatology, FIMS Collaborative Centre of Sports Medicine, FIFA Medical Centre of Excellence
Tchana-Sato, Vincent ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Language :
English
Title :
Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review Aging Clinical and Experimental Research
Canales C Wann L Blitz J Whittington R The older adult surgical patient: a review of optimization and gaps in clinical practice Perioper Med (Lond) 2025 14 1 41044779 12495825 104
Fowler AJ Abbott TEF Prowle J Pearse RM Age of patients undergoing surgery Br J Surg 2019 106 8 1012 1018 1:STN:280:DC%2BB3M7osVOiuw%3D%3D 31115918
Keller DS, Curtis N, Burt HA, Ammirati CA, Collings AT, Polk HC Jr. et al (2024) EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults. Surg Endosc 38(8):4104–4126
Theodorakis N Nikolaou M Hitas C Anagnostou D Kreouzi M Kalantzi S et al. Comprehensive peri-operative risk assessment and management of geriatric patients Diagnostics 2024 10.3390/diagnostics14192153 39767192 11675863
Cruz-Jentoft AJ Bahat G Bauer J Boirie Y Bruyere O Cederholm T et al. Sarcopenia: revised European consensus on definition and diagnosis Age Ageing 2019 48 1 16 31 30312372 6322506
Knoedler S Schliermann R Knoedler L Wu M Hansen FJ Matar DY et al. Impact of sarcopenia on outcomes in surgical patients: a systematic review and meta-analysis Int J Surg 2023 109 12 4238 62 37696253 10720826
Sadlonova M Katz NB Jurayj JS Flores L Celano CM von Arnim CAF et al. Surgical prehabilitation in older and frail individuals: a scoping review Int Anesthesiol Clin 2023 61 2 34 46 36815461 10006316
Santa Mina D Clarke H Ritvo P Leung YW Matthew AG Katz J et al. Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis Physiotherapy 2014 100 3 196 207 1:STN:280:DC%2BC2czms1Smug%3D%3D 24439570
Janssens JP Aging of the respiratory system: impact on pulmonary function tests and adaptation to exertion Clin Chest Med 2005 26 3 469 484 16140139 vi-vii
Hulzebos EH Helders PJ Favié NJ De Bie RA de la Brutel A Van Meeteren NL Preoperative intensive inspiratory muscle training to prevent postoperative pulmonary complications in high-risk patients undergoing CABG surgery: a randomized clinical trial JAMA 2006 296 15 1851 1857 1:CAS:528:DC%2BD28XhtFWms7zI 17047215
Ljungqvist O Scott M Fearon KC Enhanced recovery after surgery: a review JAMA Surg 2017 152 3 292 298 28097305
Howard R Englesbe M Leveraging the perioperative period to improve population health Perioper Med 2023 12 1 21
Chmelo J Chmelová I Phillips AW Prehabilitation, improving postoperative outcomes Rozhl Chir 2021 100 9 421 428 1:STN:280:DC%2BB2cjgt1Cgsg%3D%3D 34649450
Zhou L Li H Zhang Z Wang L Effects of multimodal prehabilitation and exercise prehabilitation on patients undergoing colorectal surgery: a systematic review and meta-analysis of randomised controlled trials J Glob Health 2024 14 39451060 11505574 04239
Perry R Herbert G Atkinson C England C Northstone K Baos S et al. Pre-admission interventions (prehabilitation) to improve outcome after major elective surgery: a systematic review and meta-analysis BMJ Open 2021 11 9 34593498 8487197 e050806
Molenaar CJ van Rooijen SJ Fokkenrood HJ Roumen RM Janssen L Slooter GD Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery Cochrane Database Syst Rev 2022 5 5 35588252 9118366 Cd013259
Blumenau Pedersen M Saxton J Birch S Rasmussen Villumsen B Bjerggaard Jensen J The use of digital technologies to support home-based prehabilitation prior to major surgery: a systematic review Surgeon J R Coll Surg Edinb Irel 2023 21 6 e305 e15
McIsaac DI Kidd G Gillis C Branje K Al-Bayati M Baxi A et al. Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials BMJ 2025 388 39843215 11752451 e081164
Kamarajah SK Bundred J Weblin J Tan BHL Critical appraisal on the impact of preoperative rehabilitation and outcomes after major abdominal and cardiothoracic surgery: a systematic review and meta-analysis Surgery 2020 167 3 540 549 31548095
Rombey T Eckhardt H Kiselev J Silzle J Mathes T Quentin W Cost-effectiveness of prehabilitation prior to elective surgery: a systematic review of economic evaluations BMC Med 2023 21 1 37468923 10354976 265
Kammerer T Mahú I Schier R Prehabilitation and inflammation Ann Nutr Metab 2025 81 4 234 44 1:CAS:528:DC%2BB2MXhvV2ksr%2FJ 40267903
Page MJ Moher D Bossuyt PM Boutron I Hoffmann TC Mulrow CD et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews BMJ (Clinical Res ed) 2021 372 n160
Sterne JAC Savović J Page MJ Elbers RG Blencowe NS Boutron I et al. RoB 2: a revised tool for assessing risk of bias in randomised trials BMJ (Clinical research ed) 2019 366 31462531 l4898
McIsaac DI Hladkowicz E Bryson GL Forster AJ Gagne S Huang A et al. Home-based prehabilitation with exercise to improve postoperative recovery for older adults with frailty having cancer surgery: the PREHAB randomised clinical trial Br J Anaesth 2022 129 1 41 8 35589429
Bojesen RD Dalton SO Skou ST Jørgensen LB Walker LR Eriksen JR et al. Preoperative multimodal prehabilitation before elective colorectal cancer surgery in patients with WHO performance status I or II: randomized clinical trial BJS Open 2023 10.1093/bjsopen/zrad134 38060453 10702628
Chen J Hong C Chen R Zhou M Lin S Prognostic impact of a 3-week multimodal prehabilitation program on frail elderly patients undergoing elective gastric cancer surgery: a randomized trial BMC Gastroenterol 2024 24 1 1:CAS:528:DC%2BB3sXhvVyitrfI 39528916 11556218 403
Barakat HM Shahin Y Khan JA McCollum PT Chetter IC Preoperative supervised exercise improves outcomes after elective abdominal aortic aneurysm repair: a randomized controlled trial Ann Surg 2016 264 1 47 53 26756766
Sethi S Ravindhran B Long J Gurung R Huang C Smith GE et al. A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair J Vasc Surg 2024 79 1 15 23.e3 37714500
Carli F Bousquet-Dion G Awasthi R Elsherbini N Liberman S Boutros M et al. Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial JAMA Surg 2020 155 3 233 242 31968063 6990653
Danielsson J Andersson M Nygren-Bonnier M Thorell A Soop M Sturesson C et al. Effect of preoperative exercise on postoperative complications after colorectal cancer surgery in older people with low physical fitness: the CANOPTIPHYS randomised controlled trial J Geriatr Oncol 2025 16 6 1:CAS:528:DC%2BB2MXht1Cnur%2FM 40450796 102280
Yang R Wolfson M Lewis MC Unique aspects of the elderly surgical population: an anesthesiologist’s perspective Geriatr Orthop Surg Rehabil 2011 2 2 56 64 23569671 3597305
de Salles ICD Sernik R da Silva JLP Taconeli C Amaral AA de Brito CMM et al. Sarcopenia, frailty, and elective surgery outcomes in the elderly: an observational study with 125 patients (the SAFESOE study) Front Med (Lausanne) 2023 10 37608827 10442161 1185016
Partridge JS Harari D Dhesi JK Frailty in the older surgical patient: a review Age Ageing 2012 41 2 142 147 22345294
Hewitt J Long S Carter B Bach S McCarthy K Clegg A The prevalence of frailty and its association with clinical outcomes in general surgery: a systematic review and meta-analysis Age Ageing 2018 47 6 793 800 30084863
Sandini M Pinotti E Persico I Picone D Bellelli G Gianotti L Systematic review and meta-analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery BJS Open 2017 1 5 128 137 1:STN:280:DC%2BB3c%2FislSjug%3D%3D 29951615 5989941
Lv YJ Xu GX Lan JR Impact of frailty on postoperative outcomes after hepatectomy: a systematic review and meta-analysis World J Gastrointest Surg 2024 16 7 2319 2328 39087100 11287678
Polanczyk CA Marcantonio E Goldman L Rohde LE Orav J Mangione CM et al. Impact of age on perioperative complications and length of stay in patients undergoing noncardiac surgery Ann Intern Med 2001 134 8 637 643 1:STN:280:DC%2BD3M3jslClsQ%3D%3D 11304103
Barnett SD Halpin LS Speir AM Albus RA Akl BF Massimiano PS et al. Postoperative complications among octogenarians after cardiovascular surgery Ann Thorac Surg 2003 76 3 726 731 12963185
Zhang X Wang S Ji W Wang H Zhou K Jin Z et al. The effect of prehabilitation on the postoperative outcomes of patients undergoing colorectal surgery: a systematic review and meta-analysis Front Oncol 2022 12 35965591 9372464 958261
Pang NQ Tan YX Samuel M Tan KK Bonney GK Yi H et al. Multimodal prehabilitation in older adults before major abdominal surgery: a systematic review and meta-analysis Langenbecks Arch Surg 2022 407 6 2193 2204 35233645
Cambriel A, Tsai A, Choisy B, Sabayev M, Hedou J, Shelton E et al (2025) Immune modulation by personalized vs standard prehabilitation before major surgery: A randomized clinical trial. JAMA Surg
Gränicher P Mulder L Lenssen T Fucentese SF Swanenburg J De Bie R et al. Exercise- and education-based prehabilitation before total knee arthroplasty: a pilot study J Rehabil Med 2024 56 38192160 10859968 jrm18326
Malot C Durand-Bouteau A Barizien N Bizard A Kennel T Fischler M et al. Prehabilitation program in elderly patients: a prospective cohort study of patients followed up postoperatively for up to 6 months J Clin Med 2021 10.3390/jcm10194500 34640516 8509125
Hua-Rui L Shouliang H Zhengze Y Ning J Peihua L Yifei Z et al. Optimal dose of resistance training to improve handgrip strength in older adults with sarcopenia: a systematic review and bayesian model-based network meta-analysis Front Physiol 2025 16 1564988 40671711 12263917
Dronkers JJ Lamberts H Reutelingsperger IM Naber RH Dronkers-Landman CM Veldman A et al. Preoperative therapeutic program me for elderly patients scheduled for elective abdominal oncological surgery: a randomized controlled pilot study Clin Rehabil 2010 24 7 614 22 1:STN:280:DC%2BC3cnis1Chug%3D%3D 20530651
Jensen BT Petersen AK Jensen JB Laustsen S Borre M Efficacy of a multiprofessional rehabilitation programme in radical cystectomy pathways: a prospective randomized controlled trial Scand J Urol 2015 49 2 133 141 25331367