Down syndrome; Alzheimer disease; aging; cognition
Abstract :
[en] Post-mortem studies of Down syndrome (DS) individuals older than 35 years show that almost 100% of them develop the neuropathological symptoms of Alzheimer disease (AD). A test battery designed to assess several domains of cognition was administered to a group of 12 DS individuals older than 35 years. It proved sensitive to individual differences and thus appears to be appropriate for the observation of cognitive change linked to age. Statistical analyses do not reveal cognitive changes in the DS subjects after one year time. However qualitative analyses of individual profiles suggest a cognitive decline in one subject. Additionally, in a PET-scan examination, three subjects present a mild decrease in cerebral glucose metabolism similar to that usually observed in AD. An AD diagnostic though remains uncertain at this stage. [fr] Les études post-mortem de sujets Down (SD) de plus de 35 ans montrent que pratiquement 100% d'entre eux développent les symptômes neuropathologiques de la maladie d'Alzheimer (MA). Dans cette étude, une batterie de tests évaluant différentes sphères de la cognition a été administrée à un groupe de 12 sujets SD âgés. Cette batterie s'est révélée sensible aux différences individuelles chez les sujets SD. Elle paraît convenir pour l'observation des changements cognitifs liés à l'âge dans ce syndrome. Les analyses statistiques ne montrent pas d'évolution dans le fonctionnement cognitif des sujets sur une période d'un an. Toutefois, l'analyse qualitative des profils cognitifs individuels montre un déclin cognitif chez un sujet. En outre, trois sujets présentent, lors d'un examen par tomographie à émission de positons, une légère modification du métabolisme cérébral semblable à celle observée dans la MA. Notons toutefois que le diagnostic à ce stade reste incertain.
Disciplines :
Neurosciences & behavior
Author, co-author :
Georges, Mercedes
Théwis, Brigitte
Van der Linden, Martial ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychopathologie cognitive
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Rondal, Jean-Adolphe ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Département de Psychologie : cognition et comportement
Language :
French
Title :
Elaboration d'une batterie d'évaluation des fonctions cognitives de sujets âgés porteurs d'un syndrome de Down
Publication date :
2001
Journal title :
Revue de Neuropsychologie
ISSN :
1155-4452
Publisher :
Association pour la Diffusion des Recherches en Sciences Cognitives de Langue Française, Marseille, France
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