Bisphenol A; Energy metabolism; Perinatal exposure; Reproduction; Seasonality; bisphenol A; Phenols; Benzhydryl Compounds; Bisphenol A Compounds; Animals; Female; Male; Phodopus/physiology; Pregnancy; Seasons; Photoperiod; Sex Factors; Sexual Maturation/drug effects; Fertility/drug effects; Reproduction/drug effects; Testis/drug effects; Energy Metabolism/drug effects; Phenols/toxicity; Prenatal Exposure Delayed Effects; Fertility; Phodopus; Sexual Maturation; Testis; Pollution; Public Health, Environmental and Occupational Health; Health, Toxicology and Mutagenesis
Abstract :
[en] Bisphenol A (BPA) has been identified as a substance of very high concern regarding its effects on the reproductive and metabolic health of human and wildlife. However, the impacts of early-life BPA exposure on the mammalian reproductive and metabolic adaptations to seasonal changes have never been addressed. We investigated the effects of perinatal BPA exposure on the fertility and maternal behaviour of the seasonal Djungarian hamster, as well as growth, puberty onset, and the ability of male and female offspring to adapt to seasonal changes later in life. Female Djungarian hamsters maintained under a long photoperiod (16 h light/8 h dark) were orally exposed to 5 µg/kg of body weight/day of BPA, or vehicle, during breeding, gestation, and lactation. BPA-treated female hamsters had a higher number of living offspring despite providing less maternal care, as compared to untreated females. Male and female offspring exposed perinatally to BPA exhibited an enhanced growth after weaning, along with reduced (in females) or normal (in males) food intake, but no modification in pubertal onset. When adult, females exposed perinatally to BPA exhibited a reduction of ovarian atretic follicles, whereas perinatally BPA-exposed males showed unaffected morphometric testicular parameters. Further, BPA-exposed females displayed a deficit in energy expenditure when compared to unexposed females. When transferred to a short photoperiod, BPA-exposed females, but not males, exhibited an accelerated integration of the short photoperiod phenotype, with faster reproductive quiescence and a larger decrease in body weight, food intake, and glycemia. Overall, this study reveals that perinatal BPA exposure in Djungarian hamsters alters maternal behaviour, offspring postnatal survival growth, and energy expenditure, and later in life reproductive and metabolic adaptations to seasonal change, with major sex differences.
Moralia, Marie-Azélie ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Bothorel, Béatrice; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France
Andry, Virginie; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France
Simonneaux, Valérie; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France
Language :
English
Title :
Sex-dependent physiological consequences of perinatal bisphenol A exposure in seasonal Djungarian hamsters.
ANSES - French Agency for Food, Environmental and Occupational Health and Safety
Funding text :
This research was funded by the French agency for food, environmental and occupational health and safety ( ANSES, PNR-EST 2018-069 ), the French Society for Endocrinology (SFE) , and the Interdisciplinary Thematic Institute NeuroStra ( ANR-10-IDEX-0002 ). We thank Dominique Ciocca, Sophie Reibel-Foisset, Nicolas Lethenet, and all the staff of the Chronobiotron\u2019s animal facility of Strasbourg for taking care of the hamsters. We thank Sakina Mhaouty-Kodja for her helpful discussions, and Yannick Goumon for the mass spectrometry supervision.
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