Polar overdominance at the ovine callipyge locus

Cockett, N.; Jackson, S.; Shaw, T.; Farnir, Frédéric; Snowder, G.; Nielsen, D.; Georges, Michel

doi:10.1126/science.273.5272.236

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Polar overdominance at the ovine callipyge locus

Cockett, N.; Jackson, S.; Shaw, T. et al.

1996 • In Science, 273 (5272), p. 236-238

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https://hdl.handle.net/2268/34401

DOI
10.1126/science.273.5272.236

PubMed
8662506

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Abstract :

[en] An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Cockett, N.

Jackson, S.

Shaw, T.

Farnir, Frédéric ; Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale

Snowder, G.

Nielsen, D.

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

Polar overdominance at the ovine callipyge locus

Publication date :

1996

Journal title :

Science

ISSN :

0036-8075

eISSN :

1095-9203

Publisher :

American Association for the Advancement of Science, Washington, United States - District of Columbia

Volume :

273

Issue :

5272

Pages :

236-238

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 January 2010

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175

Bibliography

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We are indebted to L. Ferretti and A. Teale for providing microsatellite sequence data before publication as well as to H. Lewin for sharing unpublished mapping data. We are very grateful to two anonymous reviewers for their constructive comments which allowed us to considerably improve the manuscript, and for calling our attention to the mouse Om mutation. We thank L. Andersson, A. Chakravarti, C. Haley, A. Kamb, G. Vassart, and P. Visscher for critically reviewing this manuscript before publication. This material is based on work supported by the Cooperative State Research Service, U.S. Department of Agriculture under agreement number 94-37205-1032; by the Utah Centers of Excellence program; by the Utah Agricultural Experiment Station, Utah State University, Logan, UT; and by the Fonds National pour la Recherche Scientifique, Belgium. S. B. is a fellow of the Fonds pour la Formation à la Recherche dans l'Industrie et l'Agriculture. Approved as journal paper number 4863.