[en] We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Nielsen, D.
Mackinnon, M.
Mishra, A.
Okimoto, R.
Pasquino, A. T.
Sargeant, L. S.
Sorensen, A.
Steele, M. R.
Zhao, X.
Womack, J. E.
Hoeschele, I.
Language :
English
Title :
Mapping quantitative trait loci controlling milk production by exploiting progeny testing
Publication date :
1995
Journal title :
Genetics
ISSN :
0016-6731
eISSN :
1943-2631
Publisher :
Genetics Society of America, United States - Maryland