On the detection of imprinted QTL in line crosses: effect of linkage disequilibrium

[en] Imprinted quantitative trait loci (QTL) are commonly reported in studies using line-cross designs, especially in livestock species. It was previously shown that such parent-of-origin effects might result from the nonfixation of QTL alleles in one or both parental lines, rather than from genuine molecular parental imprinting. We herein demonstrate that if linkage disequilibrium exists between marker loci and nonfixed QTL, spurious detection of pseudo-imprinting is increased by an additional 40-80% in scenarios mimicking typical livestock situations. This is due to the fact that imprinting can be tested only in F(2) offspring whose sire and dam have distinct marker genotypes. In the case of linkage disequilibrium between markers and QTL, such parents have a higher chance to have distinct QTL genotypes as well, thus resulting in distinct padumnal and madumnal allele substitution effects, i.e., QTL pseudo-imprinting.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Sandor, Cynthia ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

On the detection of imprinted QTL in line crosses: effect of linkage disequilibrium

Publication date :

2008

Journal title :

Genetics

ISSN :

0016-6731

eISSN :

1943-2631

Publisher :

Genetics Society of America, United States - Maryland

Volume :

180

Pages :

1167-1175

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 January 2010

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