Structure determined charge transport in single DNA molecule break junctions

Conductance measurement; Conformational transitions; Electronic transport properties; Molecular properties; Physical information; Single DNA molecules; Structural variations; Transition midpoint; Chemistry (all)

Abstract :

[en] Experimental study of the charge transport properties associated with structural variations due to a change in the ionic environment will provide essential physical information in determining the nature of DNA molecules. This work reports an experimental study of the change in electronic transport properties induced by the conformational transition of a poly d(GC)4 DNA. By gradually increasing the concentration of MgCl2 in the buffer solution from 0 M to 4 M, the conductance of the single DNA molecule decreased by two orders of magnitude. Circular dichroism (CD) measurements confirmed that a B to Z conformational transition caused the reduction in conductance. Using a stretch-hold mode scanning probe microscopy break junction (SPMBJ) technique, this B-Z transition process was monitored and a transition trend line was successfully achieved from conductance measurements alone. The transition midpoint occurred at a MgCl2 concentration of 0.93 M for this DNA sequence. This method provides a general tool to study transitions of molecular properties associated with conductance differences. © 2014 the Partner Organisations.

Disciplines :

Chemistry
Physics

Author, co-author :

Wang, Kun; Single Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, United States

Hamill, Joseph ; Université de Liège - ULiège > Molecular Systems (MolSys) ; Single Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, United States

Wang, Bin; Single Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, United States

Guo, Cunlan; Single Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, United States

Jiang, Sibo; Department of Chemistry, Georgia State University, Atlanta, GA 30303, United States

Huang, Zhen; Department of Chemistry, Georgia State University, Atlanta, GA 30303, United States

Xu, Bingqian; Single Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, United States

Language :

English

Title :

Structure determined charge transport in single DNA molecule break junctions

Publication date :

2014

Journal title :

Chemical Science

ISSN :

2041-6520

eISSN :

2041-6539

Publisher :

Royal Society of Chemistry

Volume :

Issue :

Pages :

3425 - 3431

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC00888J

Available on ORBi :

since 01 April 2026

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