Reference : 2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle [> >]
Dive, Georges [Université de Liège - ULiège > > Centre d'ingénierie des protéines >]
Delaude, Clément [> >]
Warin, Roger [> >]
Bassleer, Roger [> >]
Angenot, Luc mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Pergamon Press
Yes (verified by ORBi)
New York
[en] conformational study ; cytotoxic activity ; 2D NMR spectra ; 2,7-dihydroxyapogeissoschizine ; indole alkaloid ; Strychnos gossweileri
[en] In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests.
Researchers ; Professionals

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