[en] [en] BACKGROUND AND RESEARCH QUESTION: We aimed to assess whether levels of digital biomarkers can reflect monthly patterns of asthma control.
STUDY DESIGN AND METHODS: We performed a longitudinal study on patients with asthma and comorbid rhinitis who filled ≥26 days of data in a month in the MASK-air® app and who reported at least 1 day of treatment with an inhaled corticosteroid with or without a long-acting β2-agonist (ICS ± LABA). We applied k-means cluster analysis to define clusters of months according to daily asthma control and medication use. Clusters were compared using digital biomarkers (visual analogue scale [VAS] on asthma symptoms and electronic daily asthma control score [e-DASTHMA]). We compared patients who did not switch with patients who switched their ICS ± LABA.
RESULTS: We assessed 243 patients and 1358 months. We identified three clusters of poor asthma control despite high ICS ± LABA adherence, one cluster of poor asthma control and poor ICS ± LABA adherence, one cluster of good asthma control and high ICS ± LABA adherence and one cluster of good asthma control despite poor ICS ± LABA adherence. These clusters displayed relevant differences in VAS asthma and e-DASTHMA levels. Similar clusters were found in 'non-switchers' versus 'switchers'.
CONCLUSION: Levels of digital biomarkers reflect asthma control patterns and might be used to monitor patients with asthma.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Sousa-Pinto, Bernardo; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Schleich, Florence ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Physiologie humaine et physiologie de l'effort physique
Louis, Gilles ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Gemicioglu, Bilun; Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey ; Institute of Pulmonology and Tuberculosis, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey
Kvedarienė, Violeta; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania ; Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Regateiro, Frederico S; Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal ; Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal ; Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Chaves Loureiro, Claudia; Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal ; Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Taborda-Barata, Luis; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal ; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Amaral, Rita; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Antó, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain ; Universitat Pompeu Fabra (UPF), Barcelona, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Bedbrook, Anna; ARIA, Montpellier, France
Czarlewski, Wienczyslawa; ARIA, Montpellier, France ; Medical Consulting Czarlewski, Levallois, France
Ansotegui, Ignacio J; Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
Bergmann, Karl-C; Institute of Allergology Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Immunology and Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
Bonini, Matteo; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy ; National Health and Lung Institute (NHLI), Imperial College London, London, UK
Bossios, Apostolos; Severe Asthma Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden ; Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Boulet, Louis-Philippe; Quebec Heart and Lung Institute, Laval University, Québec City, Québec, Canada
Braido, Fulvio ; Respiratory and Allergy Clinic, IRCCS - Policlinico San Martino, Genoa, Italy ; Department of Internal Medicine (DIMI), University of Genoa, Genoa, Italy
Brightling, Christopher; Institute for Lung Health, Leicester NIHR BRC, University of Leicester, UK
Brusselle, Guy; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Brussino, Luisa; Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy ; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
Canonica, G Walter; Asthma and Allergy Unit-IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy ; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
Cruz, Alvaro A; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Haahtela, Tari; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, UK
Heaney, Liam G; Plymouth University, Plymouth, UK
Hyland, Michael; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
Ivancevich, Juan Carlos; Department of Otolaryngology Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany
Klimek, Ludger; Center for Rhinology and Allergology, Wiesbaden, Germany ; Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland
Kulus, Marek; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kuna, Piotr; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Kupczyk, Maciej; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Larenas-Linnemann, Desiree E; Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, 'Attikon' University Hospital institution institution, Athens, Greece
Makris, Michael; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
Marques-Cruz, Manuel; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Gil-Mata, Sara; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Morais-Almeida, Mário; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Niedoszytko, Marek; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg
Ollert, Markus; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark ; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Papadopoulos, Nikolaos G; Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Salerno, Italy
Patella, Vincenzo; Agency of Health ASL, Salerno, Italy ; Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy ; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Pfaar, Oliver; Department of Respiratory and Infectious Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
Porsbjerg, Celeste; Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain
Puggioni, Francesca; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
Quirce, Santiago; Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Robalo Cordeiro, Carlos; Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France
Roche, Nicolas; UMR 1016, Institut Cochin, Paris, France ; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France ; Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain
Samolinski, Boleslaw; PROMISE Department, University of Palermo, Palermo, Italy
Sastre, Joaquin; Department of Pulmonary Diseases and Allergy, Ljubljana University Medical Centre, Ljubljana, Slovenia
Scichilone, Nicola; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
Skrgat, Sabina; Department of Otorhinolaryngology, University of Eastern Finland and the North Savo wellbeing services county, Kuopio, Finland ; Department of Allergy, Skin and Allergy Hospital, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Toppila-Salmi, Sanna; Royal Brompton Hospital, Airways Disease Section, London, UK ; Clinic of Children's Diseases, Institute of Clinical Medicine, Medical Faculty of Vilnius University, Vilnius, Lithuania
Usmani, Omar S; National Health and Lung Institute (NHLI), Imperial College London, London, UK ; Clinic of Asthma, Allergy, and Chronic Lung Diseases, Vilnius, Lithuania
Valiulis, Arunas; Department of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, Lithuania ; University of Bari Medical School, Bari, Italy
Gradauskiene, Brigita; Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy
Vardaloğlu Koyuncu, Ilgim; Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey
Ventura, Maria Teresa; Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey ; Department of Medical Sciences, University of Torino, Torino, Italy
Vieira, Rafael José; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Yorgancioglu, Arzu; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw institution, Warsaw, Poland
Fonseca, João A; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Zuberbier, Torsten; Institute of Allergology Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Immunology and Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Bousquet, Jean ; ARIA, Montpellier, France ; Institute of Allergology Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Immunology and Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
GSK - GlaxoSmithKline Novartis ULiège - University of Liège
Funding text :
L-P. Boulet reports grants from Amgen, AstraZeneca, GlaxoSmithKline, Merck, Novartis, Sanofi-Regeneron, others from AstraZeneca, Novartis, GlaxoSmithKline, Merck, Sanofi-Regeneron, outside the submitted work.O. Pfaar reports grants and personal fees from ALK-Abell\u00F3, grants and personal fees from Allergopharma, grants and personal fees from Stallergenes Greer, grants and personal fees from HAL Allergy Holding B.V./HAL Allergie GmbH, grants and personal fees from Bencard Allergie GmbH/Allergy Therapeutics, grants and personal fees from Laboratorios LETI/LETI Pharma, grants and personal fees from GlaxoSmithKline, personal fees from ROXALL Medizin, personal fees from Novartis, grants and personal fees from Sanofi-Aventis and Sanofi-Genzyme, personal fees from Med Update Europe GmbH, personal fees from streamedup! GmbH, grants from Pohl-Boskamp, grants from Inmunotek S.L., personal fees from John Wiley and Sons, AS, personal fees from Paul-Martini-Stiftung (PMS), personal fees from Regeneron Pharmaceuticals Inc., personal fees from RG Aerztefortbildung, personal fees from Institut f\u00FCr Disease Management, personal fees from Springer GmbH, grants and personal fees from AstraZeneca, personal fees from IQVIA Commercial, personal fees from Ingress Health, personal fees from Wort&Bild Verlag, personal fees from Verlag ME, personal fees from Procter&Gamble, personal fees from ALTAMIRA, personal fees from Meinhardt Congress GmbH, personal fees from Deutsche Forschungsgemeinschaft, personal fees from Thieme, grants from Deutsche AllergieLiga e.V., personal fees from AeDA, personal fees from Alfried-Krupp Krankenhaus, personal fees from Red Maple Trials Inc., personal fees from K\u00F6niglich D\u00E4nisches Generalkonsulat, personal fees from Medizinische Hochschule Hannover, personal fees from ECM Expro&Conference Management, personal fees from Technical University Dresden, personal fees from Lilly, personal fees from Japanese Society of Allergy, personal fees from Forum f\u00FCr Medizinische Fortbildung, personal fees from Dustri-Verlag, personal fees from Pneumolive, grants and personal fees from ASIT Biotech, grants and personal fees from LOFARMA, personal fees from Paul-Ehrlich-Institut, personal fees from Almirall, outside the submitted work; and member of EAACI Excom, member of ext. board of directors DGAKI; coordinator, main- or co-author of different position papers and guidelines in rhinology, allergology and allergen-immunotherapy; associate editor (AE) of Allergy and Clinical Translational Allergy.D. Larenas Linnemann reports personal fees from ALK, AstraZeneca national and global, Bayer, Chiesi, Grunenthal, Grin, GSK national and global, Viatris, Menarini, MSD, Novartis, Pfizer, Sanofi, Siegfried, Carnot, grants from Abbvie, Bayer, Lilly, Sanofi, AstraZeneca, Pfizer, Novartis, Pulmonair, GSK, Chiesi, outside the submitted work; and Editor-in-chief of Immune System (Karger); Member of asthma committee ACAAI; Subgroup chair of allergen immunotherapy Practice parameter update JTF AAAAI/ACAAI 2024; Member of allergen immunotherapy committee AAAAI; Chair of allergen immunotherapy committee CMICA; Member of allergic asthma task force EAACI.N. Papadopoulos reports grants from Capricare, Nestle, Numil, Vianex, REG, other from Abbott, AbbVie, Astra Zeneca, GSK, HAL, Medscape, Menarini/Faes Farma, Mylan, Novartis, Nutricia, OM Pharma, Regeneron/Sanofi, outside the submitted work.
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