[en] [en] INTRODUCTION: Osteoarthritis (OA) is a chronic, progressive joint disease characterized by the degradation of articular cartilage, subchondral bone remodeling, synovial inflammation, and osteophyte formation. Despite being a leading cause of disability in older people, effective long-term management of OA remains a significant challenge. Current treatment strategies primarily focus on symptom control, with both non-pharmacological and pharmacological interventions.
MATERIALS AND METHODS: A systematic literature review followed by a structured Delphi survey was conducted, involving an international Technical Expert Panel (TEP) of OA specialists. The panel evaluated the efficacy, safety, and clinical utility of combining low dose diclofenac and chondroitin sulfate in OA management.
RESULTS: The analysis of expert consensus indicated that the combination of low dose diclofenac and chondroitin sulfate may be effective in reducing pain and improving joint function in patients with knee OA. Additionally, this combination could reduce the need for higher doses of NSAIDs, thereby minimizing systemic adverse effects.
CONCLUSION: The combination of low dose diclofenac and chondroitin sulfate represents a promising therapeutic strategy for managing knee OA. Further studies are needed to confirm these findings and optimize therapeutic strategies to improve patient outcomes.
Disciplines :
Public health, health care sciences & services General & internal medicine
Author, co-author :
Migliore, Alberto ; Rheumatology Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy
De Lucia, Orazio ; Department of Rheumatology and Medical Sciences, Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Milan, Italy. orazio.delucia@asst-pini-cto.it
de Sire, Alessandro ; Physical and Rehabilitative Medicine, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, 88100, Italy ; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro "Magna Graecia", Catanzaro, 88100, Italy
Šajbidor, Andrea ; Špecializovaná Nemocnica Pre Ortopedickú Protetiku, Záhradnícka 42, Bratislava, 821 08, Slovakia ; Orthopedic Clinic, Bratislava, Slovakia
Šenolt, Ladislav; Institute of Rheumatology, Na Slupi 4, Prague, 128 00, Czech Republic ; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic
Szántó, Sándor ; Faculty of Medicine, Department of Sports Medicine, University of Debrecen, Debrecen, Hungary
Fontova, Joan Calvet ; Department of Rheumatology, Medicine Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain
Flechtenmacher, Johannes ; Ortho-Zentrum Karlsruhe, Waldstrasse 67, 76133, Karlsruhe, Germany
Mobasheri, Ali ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Research Unit of Health Sciences and Technology, Physics and Technology, University of Oulu, Oulu, Finland ; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania ; Department of Joint Surgery, Sun Yat-sen University, Guangzhou, People's Republic of China
Faure, Jordi Monfort ; Department of Rheumatology, Institut Hospital del Mar d'Investigacions Mèdiques, Passeig Marítim de la Barceloneta, 25, 29, 08003, Barcelona, Spain
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique ; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Veronese, Nicola ; Saint Camillus International University of Health Sciences, Rome, Italy ; Unità Locale Socio Sanitaria 3 Serenissima, Primary Care Department, Dolo Mirano, Venice, Italy
Language :
English
Title :
Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.
Publication date :
06 November 2025
Journal title :
Aging Clinical and Experimental Research
ISSN :
1594-0667
eISSN :
1720-8319
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
The publication of this article was supported by a non-conditioning grant from IBSA International (Lugano, Switzerland). The participation of JYR to this work has been supported by the DSFP of King Saud University, Riyad, Kingdom of Saudi Arabia.
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