Neural Correlates of Anesthesia in Newborn Mice and Humans.

EEG; LFP; anesthesia; development; human; machine learning; mouse; network dynamics; Anesthetics; Anesthetics/pharmacology; Animals; Animals, Newborn; Brain/drug effects; Brain/physiology; Electroencephalography; Female; Humans; Infant; Infant, Newborn; Machine Learning; Male; Mice; Mice, Inbred C57BL; Algorithms; Anesthesia; Brain; Neuroscience (miscellaneous); Sensory Systems; Cognitive Neuroscience; Cellular and Molecular Neuroscience

Abstract :

[en] Monitoring the hypnotic component of anesthesia during surgeries is critical to prevent intraoperative awareness and reduce adverse side effects. For this purpose, electroencephalographic (EEG) methods complementing measures of autonomic functions and behavioral responses are in use in clinical practice. However, in human neonates and infants existing methods may be unreliable and the correlation between brain activity and anesthetic depth is still poorly understood. Here, we characterized the effects of different anesthetics on brain activity in neonatal mice and developed machine learning approaches to identify electrophysiological features predicting inspired or end-tidal anesthetic concentration as a proxy for anesthetic depth. We show that similar features from EEG recordings can be applied to predict anesthetic concentration in neonatal mice and humans. These results might support a novel strategy to monitor anesthetic depth in human newborns.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Chini, Mattia ; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Gretenkord, Sabine; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Kostka, Johanna K; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Pöpplau, Jastyn A; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Cornelissen, Laura; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, United States ; Department of Anesthesia, Harvard Medical School, Boston, MA, United States

Berde, Charles B; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, United States ; Department of Anesthesia, Harvard Medical School, Boston, MA, United States

Hanganu-Opatz, Ileana L; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Bitzenhofer, Sebastian H; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Language :

English

Title :

Neural Correlates of Anesthesia in Newborn Mice and Humans.

Publication date :

2019

Journal title :

Frontiers in Neural Circuits

eISSN :

1662-5110

Publisher :

Frontiers Media S.A., Switzerland

Volume :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.frontiersin.org/article/10.3389/fncir.2019.00038/full

Funding text :

This work was funded by grants from the European Research Council (ERC-2015-CoG 681577 to IH-O), the German Research

Available on ORBi :

since 18 March 2026

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