Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse.

cortical development; hippocampal; mouse; neuroscience; optogenetics; oscillations; prefrontal; Receptors, Glutamate; Glutamic Acid; Action Potentials; Animals; Animals, Newborn; Female; Glutamic Acid/metabolism; Hippocampus/physiology; Interneurons/physiology; Male; Mice; Mice, Inbred C57BL; Neural Pathways/physiology; Optogenetics; Prefrontal Cortex/physiology; Pyramidal Cells/physiology; Receptors, Glutamate/metabolism; Theta Rhythm; Hippocampus; Interneurons; Neural Pathways; Prefrontal Cortex; Pyramidal Cells; Neuroscience (all); Immunology and Microbiology (all); Biochemistry, Genetics and Molecular Biology (all)

Abstract :

[en] The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Ahlbeck, Joachim ; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Song, Lingzhen; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Chini, Mattia ; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Bitzenhofer, Sebastian H; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Hanganu-Opatz, Ileana L ; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Language :

English

Title :

Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse.

Publication date :

10 April 2018

Journal title :

eLife

eISSN :

2050-084X

Publisher :

eLife Sciences Publications Ltd, England

Volume :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://cdn.elifesciences.org/articles/33158/elife-33158-v1.pdf

Funders :

ERC - European Research Council
DFG - Deutsche Forschungsgemeinschaft

Funding text :

We thank Nadine Faesel for the establishment of tracing technique, Antonio Candela for preliminary tracing data, Drs. L Cancedda and A Cwetsch for help with the in utero electroporation, Drs. S Wie-gert, T Oertner, and C Gee for help with the development of opsin constructs as well as A Mar-quardt, P Putthoff, A Dahlmann and I Ohmert for excellent technical assistance. ILH-O acknowledges support by the ERC (ERC Consolidator Grant 681577) and by the German Research Foundation (SFB 936 (B5) and SPP 1665 (Ha4466/12-1)). ILH-O is the member of the FENS Kavli Network of Excellence. In memoriam of Howard Eichenbaum

Available on ORBi :

since 18 March 2026

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