[en] Sinusoidal obstruction syndrome (SOS) formerly known as Veno-occlusive disease (VOD) is a potentially fatal complication that occurs mainly after haematopoietic cell transplantation, especially allogeneic transplantation. The liver is the principal organ affected, though other organs, such as the lungs, may also be involved to a lesser extent. The condition is characterised by obstruction of the hepatic venules, leading to sinusoidal congestion, hepatic ischaemia and, in severe cases, fulminant liver failure. Recent refined diagnostic criteria, published by the European Society for Blood and Marrow Transplantation in 2023, provide a more accurate method of detecting SOS/VOD, allowing earlier intervention and better stratification of patients according to the severity of their disease. This article focuses on liver SOS/VOD and discussing key risk factors, new diagnostic methods and therapeutic strategies, with an emphasis on the early use of defibrotide, which remains the reference treatment for severe SOS/VOD.
Disciplines :
Hematology
Author, co-author :
Larue, Marion ; Hematology Department, AP-HP, Hôpital Saint-Antoine, Sorbonne Université, Paris, France. marion.larue@hotmail.fr
Malard, Florent; Hematology Department, AP-HP, Hôpital Saint-Antoine, Sorbonne Université, Paris, France ; Sorbonne Université, Centre de Recherche Saint-Antoine, INSERM UMRs938, Paris, France
Alaskar, Ahmed S; Department of Oncology, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
Aljurf, Mahmoud ; King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Arat, Mutlu; HSCT Unit, Sisli Florence Nightingale Hospital, Istanbul, Turkey
Balsat, Marie; Clinical Hematology Department, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France
Baron, Frédéric ; Université de Liège - ULiège > Département des sciences cliniques
Basak, Grzegorz; Medical University of Warsaw, Warsaw, Poland
Bazarbachi, Ali ; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
Bonifazi, Francesca ; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Brissot, Eolia ; Hematology Department, AP-HP, Hôpital Saint-Antoine, Sorbonne Université, Paris, France ; Sorbonne Université, Centre de Recherche Saint-Antoine, INSERM UMRs938, Paris, France
Ciceri, Fabio ; Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy ; University Vita-Salute San Raffaele, Milan, Italy
Corbacioglu, Selim ; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany
Dignan, Fiona; Department of Clinical Haematology, Central Manchester Foundation Trust, Manchester, UK
Huynh, Anne; Hematology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France
Kenyon, Michelle ; Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, UK
Kuball, Jürgen ; Department of Haematology, University Medical Centre, Utrecht, The Netherlands
Lachance, Silvy ; Department of Hematology and Stem Cell Transplant Program, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, QC, Canada
Masszi, Tamas; Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Nagler, Arnon ; Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel
Okamoto, Shinichiro; Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
Pagliuca, Antonio ; Department of Haematological Medicine, King's College Hospital, London, UK
Ruggeri, Annalisa ; Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy
Ruutu, Tapani ; Clinical Research Institute and Unit of Coagulation Disorders, Comprehensive Cancer Center, Helsinki University Hospital, and Research Program Unit in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Yakoub-Agha, Ibrahim; CHU de Lille, Univ de Lille, LIRIC INSERM U1286995, Université de Lille 2 Infinite, Lille, France
Ye, Yishan ; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Duarte, Rafael F ; Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
Perić, Zinaida; Department of hematology, University Hospital Centre Rijeka, Rijeka, Croatia
Carreras, Enric ; Hematology Department, Josep Carreras Foundation and Leukemia Research Institute, Hospital Clínic, Barcelona, Spain
Mohty, Mohamad ; Hematology Department, AP-HP, Hôpital Saint-Antoine, Sorbonne Université, Paris, France ; Sorbonne Université, Centre de Recherche Saint-Antoine, INSERM UMRs938, Paris, France
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