Article (Scientific journals)
When loss speaks louder than depression: previous early pregnancy loss as a stronger predictor of mother-infant dyadic disruption.
Bezzan, Graziella; Seutin, Vincent; Keren, Miri
2026 • In Journal of Psychosomatic Obstetrics and Gynaecology, 47 (1), p. 2630776
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Keywords :
Postpartum depression; dyadic synchrony; early pregnancy loss; mother-infant interaction; perinatal mental Health; reproductive history; Humans; Female; Adult; Cross-Sectional Studies; Pregnancy; Young Adult; Severity of Illness Index; Infant; Mother-Child Relations/psychology; Depression, Postpartum/psychology; Abortion, Spontaneous/psychology; Mothers/psychology; Abortion, Spontaneous; Depression, Postpartum; Mother-Child Relations; Mothers; Reproductive Medicine; Clinical Psychology; Obstetrics and Gynecology; Psychiatry and Mental Health
Abstract :
[en] [en] BACKGROUND: Postpartum depression (PPD) disrupts early mother-infant synchrony, a key determinant of healthy socio-emotional development. The relational impact of prior early pregnancy loss (EPL) remains largely underexplored. OBJECTIVE: This exploratory cross-sectional study examined the independent and combined effects of PPD severity and prior EPL on mother-infant synchrony. METHOD: Ninety-six mother-infant dyads, recruited from a population vulnerable to depressive symptoms, were assigned to a control group or to one of three PPD severity groups (mild, moderate, severe). Dyadic synchrony was assessed using the CARE-Index, and EPL history was recorded. Chi-square tests and binary logistic regressions evaluated the effects of PPD severity and EPL on low synchrony. RESULTS: EPL significantly predicted low synchrony (OR = 7.50, 95% CI [1.16-48.36], p = 0.034), independently of PPD severity. Although depressive symptoms showed no overall significant effect (p = 0.123), a severity-response trend emerged: mild (OR = 3.06, p = 0.09), moderate (OR = 3.57, p = 0.06), severe (OR = 7.50, p = 0.01). No interaction between EPL and PPD was found. CONCLUSIONS: Prior EPL appears to have lasting effects on mother-infant synchrony, independent of current depressive severity. Larger studies are needed to confirm these findings.
Disciplines :
Psychiatry
Author, co-author :
Bezzan, Graziella  ;  Université de Liège - ULiège > GIGA
Seutin, Vincent  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Keren, Miri;  Bar Ilan University Azrieli Medical School, Ramat Gan, Israël
Language :
English
Title :
When loss speaks louder than depression: previous early pregnancy loss as a stronger predictor of mother-infant dyadic disruption.
Publication date :
31 December 2026
Journal title :
Journal of Psychosomatic Obstetrics and Gynaecology
ISSN :
0167-482X
Publisher :
Taylor and Francis Ltd., England
Volume :
47
Issue :
1
Pages :
2630776
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 March 2026

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