Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion

Charmoy, Mélanie; Maier, Julia M; Wyss, Tania; Chennupati, Vijaykumar; Sabatel, Catherine; Bonneaux, Laurie; Dumez, Alexandre; Romain, Romain; Guarda, Greta; Held, Werner

Article (Scientific journals)

Charmoy, Mélanie; Maier, Julia M; Wyss, Tania et al.

2026 • In Frontiers in Immunology

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/340549

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Disciplines :

Immunology & infectious disease

Author, co-author :

Charmoy, Mélanie

Maier, Julia M

Wyss, Tania

Chennupati, Vijaykumar

Sabatel, Catherine ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > Biochimie et biologie moléculaire ; Université de Liège - ULiège > GIGA > GIGA Immunobiology - Cellular and Molecular Immunology

Bonneaux, Laurie

Dumez, Alexandre

Romain, Romain

Guarda, Greta

Held, Werner

Language :

English

Title :

Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion

Publication date :

2026

Journal title :

Frontiers in Immunology

eISSN :

1664-3224

Publisher :

Frontiers Research Foundation, Lausanne, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 January 2026

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