Whipple's Disease Presenting with Bone Marrow Findings Mimicking Prefibrotic Myelofibrosis: A Diagnostic Pitfall.

[en] Whipple's disease is a rare systemic infection that may mimic hematologic disorders. We report a case initially misdiagnosed as prefibrotic myelofibrosis based on systemic symptoms and bone marrow findings. Further investigations by PCR confirmed Tropheryma whipplei infection. Antibiotic therapy led to full clinical remission and resolution of bone marrow abnormalities. This case highlights the importance of considering infectious etiologies in patients with constitutional symptoms and bone marrow changes, to avoid misdiagnosis and inappropriate management.

Disciplines :

Hematology

Author, co-author :

Vertenoeil, Gaëlle ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique

HAFRAOUI, Kaoutar ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique

Collins, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

Somja, Joan ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Lambert, Frédéric ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

De Worm, Sophie ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Maladies infectieuses et médecine interne générale

Beguin, Yves ; Université de Liège - ULiège > Département des sciences cliniques

Language :

English

Title :

Whipple's Disease Presenting with Bone Marrow Findings Mimicking Prefibrotic Myelofibrosis: A Diagnostic Pitfall.

Publication date :

30 November 2025

Journal title :

International Journal of Infectious Diseases

ISSN :

1201-9712

eISSN :

1878-3511

Publisher :

Elsevier BV, Canada

Pages :

108271

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S120197122500493X?httpAccept=text/xml

Available on ORBi :

since 07 January 2026

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Bibliography

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