Geriatric assessment; Geriatric screening; Multiple myeloma; Oncology; Geriatrics and Gerontology
Disciplines :
Hematology
Author, co-author :
Raddoux, Jolien; Department of hematology, UZ Leuven Gasthuisberg, Belgium
Kenis, Cindy; Department of General Medical Oncology, UZ Leuven, Leuven, Belgium, Department of Geriatric Medicine, UZ Leuven, Leuven, Belgium, Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven, Leuven, Belgium
Vanhellemont, Anneleen; Department of hematology, UZ Leuven Gasthuisberg, Belgium
Meers, Stef; Department of hematology, AZ Klina, Brasschaat, Belgium
Mineur, Philippe; Department of hematology, GHdC Charleroi, Charleroi, Belgium
Vekemans, Marie-Christiane; Department of hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium
Wu, Ka Lung; Department of hematology, Ziekenhuis aan de Stroom, Antwerpen, Belgium
Caers, Jo ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Van Eygen, Koen; Department of hematology, AZ Groeninge, Kortrijk, Belgium
Kentos, Alain; Department of hematology, Hôpital de Jolimont, Haine-Saint-Paul, Belgium
Depaus, Julien; Department of hematology, CHU UCL Namur, Godinne, Belgium
Put, Natalie; Department of hematology, Ziekenhuis Oost-Limburg, Genk, Belgium
Van De Velde, Ann; Department of hematology, Heilig Hartziekenhuis Lier, Lier, Belgium
Claes, Géraldine; Department of hematology, EpiCURA, Hornu, Belgium
Vlummens, Philip; Department of hematology, UZ Gent, Gent, Belgium
Maertens, Vincent; Department of hematology, Imelda ziekenhuis, Bonheiden, Belgium
Meuleman, Nathalie; Department of hematology, Institut Jules Bordet, Anderlecht, Belgium
Broek, Isabelle Vande; Department of hematology, VITAZ, Sint-Niklaas, Belgium
Vaes, Mélanie; Department of hematology, CHU Tivoli, La Louvière, Belgium
Fostier, Karel; Department of hematology, UZ Brussel, Brussel, Belgium
Demuynck, Hilde; Department of oncology-hematology, Jan Yperman ziekenhuis, Ieper, Belgium
Delforge, Michel; Department of hematology, UZ Leuven Gasthuisberg, Belgium. Electronic address: Michel.delforge@uzleuven.be
This study was supported by an unrestricted grant from Celgene BMS .This study was supported by an unrestricted grant from Celgene BMS.This study was conducted within the MM study group of the Belgium Hematological Society (BHS). The authors would also like to thank Annouschka Laenen from Biostatistics KU Leuven for statistical support. The study was registered at Clinical Trials.gov with number NCT02918695.
Rajkumar, S.V., Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management. Am J Hematol 99:9 (2024), 1802–1824, 10.1002/ajh.27422.
Facon, T., Leleu, X., Manier, S., How I treat multiple myeloma in geriatric patients. Blood 143:3 (2024), 224–232, 10.1182/blood.2022017635.
Terpos, E., Mikhael, J., Hajek, R., Chari, A., Zweegman, S., Lee, H.C., et al. Management of patients with multiple myeloma beyond the clinical-trial setting: understanding the balance between efficacy, safety and tolerability, and quality of life. Blood Cancer J, 11(2), 2021, 40, 10.1038/s41408-021-00432-4.
Fried, L.P., Ferrucci, L., Darer, J., Williamson, J.D., Anderson, G., Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59:3 (2004), 255–263, 10.1093/gerona/59.3.m255.
van Walree, I.C., Scheepers, E., van Huis-Tanja, L., Emmelot-Vonk, M.H., Bellera, C., Soubeyran, P., et al. A systematic review on the association of the G8 with geriatric assessment, prognosis and course of treatment in older patients with cancer. J Geriatr Oncol 10:6 (2019), 847–858, 10.1016/j.jgo.2019.04.016.
Bellera, C.A., Rainfray, M., Mathoulin-Pélissier, S., Mertens, C., Delva, F., Fonck, M., et al. Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol 23:8 (2012), 2166–2172, 10.1093/annonc/mdr587.
Palumbo, A., Bringhen, S., Mateos, M.V., Larocca, A., Facon, T., Kumar, S.K., et al. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an international myeloma working group report. Blood 125:13 (2015), 2068–2074, 10.1182/blood-2014-12-615187.
Facon, T., Dimopoulos, M.A., Meuleman, N., Belch, A., Mohty, M., Chen, W.M., et al. A simplified frailty scale predicts outcomes in transplant-ineligible patients with newly diagnosed multiple myeloma treated in the FIRST (MM-020) trial. Leukemia 34:1 (2020), 224–233, 10.1038/s41375-019-0539-0.
Coulson, A.B., Royle, K.L., Pawlyn, C., Cairns, D.A., Hockaday, A., Bird, J., et al. Frailty-adjusted therapy in transplant non-eligible patients with newly diagnosed multiple myeloma (FiTNEss (UK-MRA myeloma XIV trial)): a study protocol for a randomised phase III trial. BMJ Open, 12(6), 2022, e056147, 10.1136/bmjopen-2021-056147.
Yao, Y., Sui, W.W., Liao, A.J., Wang, W., Chen, L.J., Chu, X.X., et al. Comprehensive geriatric assessment in newly diagnosed older myeloma patients: a multicentre, prospective, non-interventional study. Age Ageing, 51(1), 2022, afab211, 10.1093/ageing/afab211.
Kenis, C., Bron, D., Libert, Y., Decoster, L., Van Puyvelde, K., Scalliet, P., et al. Relevance of a systematic geriatric screening and assessment in older patients with cancer: results of a prospective multicentric study. Ann Oncol 24:5 (2013), 1306–1312, 10.1093/annonc/mds619.
Dale, W., Klepin, H.D., Williams, G.R., Alibhai, S.M.H., Bergerot, C., Brintzenhofeszoc, K., et al. Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy: ASCO guideline update. J Clin Oncol 41:26 (2023), 4293–4312, 10.1200/JCO.23.00933.
Groen, K., Smits, F., Nasserinejad, K., Levin, M.D., Regelink, J.C., Timmers, G.J., et al. Assessing frailty in myeloma: the pursuit of simplicity may sacrifice precision of predicting clinical outcomes. Hemasphere, 8(7), 2024, e85 Published 2024 Jul 4 https://doi.org/10.1002/hem3.85.
Facon, T., Dimopoulos, M.A., Leleu, X.P., Beksac, M., Pour, L., Hájek, R., et al. Isatuximab, bortezomib, lenalidomide, and dexamethasone for multiple myeloma. N Engl J Med 391:17 (2024), 1597–1609, 10.1056/NEJMoa2400712.
Mian, H., Wildes, T.M., Vij, R., Pianko, M.J., Major, A., Fiala, M.A., Dynamic frailty risk assessment among older adults with multiple myeloma: a population-based cohort study. Blood Cancer J, 13(1), 2023, 76, 10.1038/s41408-023-00843-5.