[en] Importance. Most French Olfactory Questionnaires are time consuming, which may affect the patient participation. Objective. To validate a short French version of the Olfactory Disorders Questionnaire (Fr-ODQ). Design. Prospective controlled study. Setting. Multicenter study. Participants. Patients with long-lasting olfactory dysfunction (OD) treated with platelet-rich plasma into the olfactory clefts and asymptomatic subjects. Intervention. Development and validation of a short ODQ. Main Outcomes. Individuals completed the full Fr-ODQ. The Threshold, Discrimination, and Identification (TDI) test was performed in OD patients. A combined statistical analysis was performed to determine the most informative items of the Fr-ODQ to develop a shorter version. The internal consistency was determined with Cronbach's alpha. The reliability and external validity were evaluated through a test-retest approach and by correlating with the Fr-ODQ. Both the minimal clinically important difference (MCID) and the threshold of the short ODQ version were determined. Results. A total of 263 patients (173 [65.8%] females) and 129 controls (92 [71.3%] females) completed the evaluations. The mean age of patients was 51.2 ± 15.3 years. The mean duration of OD was 42.4 ± 54.3 months. The biostatistical models selected 10 essential items composing the Fr-ODQ-10. The baseline Fr-ODQ-10 was significantly correlated with the TDI (r s = 0.228; P = .001) and the Fr-ODQ (r s = 0.875; P = .001), demonstrating high external validity. Fr-ODQ-10 was significantly lower in controls compared to OD patients (P = .001), highlighting high internal validity. The internal consistency was good (α = .796). The external consistency was adequate, with significant correlations between the test-retest Fr-ODQ-10. The Fr-ODQ-10 significantly decreased from baseline to 4 months post-treatment. A Fr-ODQ-10 score >7.5 was considered abnormal (sensitivity: 84.8%, specificity: 84.2%). The MCID of Fr-ODQ-10 was established at >3. Conclusion and Relevance. The Fr-ODQ-10 is a valid and reliable clinical instrument, demonstrating correlation with the psychophysical olfactory assessment.
Disciplines :
Otolaryngology
Author, co-author :
Lechien, Jérôme ; Department of Surgery, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium ; Department of Otolaryngology, Elsan Hospital, Paris, France
Vaira, Luigi; Department of Otorhinolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France ; Department of Otolaryngology-Head & Neck Surgery, CHU Saint-Pierre, Brussels, Belgium ; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy ; Biomedical Science Department, PhD School of Biomedical Science, University of Sassari, Sassari, Italy
Lamoulen, Lea; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Computational Medicine and Neuropsychiatry, University of Mons, Mons, Belgium
Sowerby, Leigh; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Otolaryngology-Head & Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Canada
Radulesco, Thomas; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department, Aix Marseille Univ, APHM, CNRS, IUSTI, La Conception University Hospital, ENT-HNS, Marseille, France
Michel, Justin; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department, Aix Marseille Univ, APHM, CNRS, IUSTI, La Conception University Hospital, ENT-HNS, Marseille, France
Boscolo-Rizzo, Paolo; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Section of Otolaryngology, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
Salzano, Giovanni; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Neurosciences, Reproductive and Odontostomatological Sciences, Maxillofacial Surgery Unit, University Federico II, Naples, Italy
Barillari, Maria; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Naples SUN, Naples, Italy
Saibene, Alberto; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Health Sciences, Otolaryngology Unit, ASST Santi Paolo E Carlo, Università Degli Studi Di Milano, Milan, Italy
Cammaroto, Giovanni; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Otolaryngology-Head & Neck Surgery, Forli Hospital, Forli, Italy
Chiesa-Estomba, Carlos; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain
Iannella, Giannicola ; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Organi di Senso, Sapienza Università di Roma, Rome, Italy
Van Der Poel, Nicolien; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Otorhinolaryngology-Head & Neck Surgery, Antwerp University Hospital, Edegem, Belgium ; Department of Translational Neuroscience, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium
Sagandykova, Kalamkas ; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; School of Medicine, University Medical Center Corporate Fund, Nazarbayev University, Astana, Kazakhstan
Saussez, Sven; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Human Anatomy and Experimental Oncology, University of Mons, Mons, Belgium
Carsuzaa, Florent ; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Otolaryngology-Head & Neck Surgery, CHU de Poitiers, Poitiers, France
Mayo-Yanez, Miguel; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Otorhinolaryngology-Head & Neck Surgery, Complexo Hospitalario Universitario A Coruña (CHUAC), Coruña, Spain
Bhargava, Kamta; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of ENT, Sheffield Children's Hospital, Sheffield, UK ; Faculty of Health, University of Sheffield, Sheffield, UK
Maniaci, Antonino; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Medicine and Surgery, University of Enna "Kore, Enna, Italy
Briganti, Giovanni ; Université de Liège - ULiège > Département des sciences cliniques > Santé digitale ; Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France ; Department of Computational Medicine and Neuropsychiatry, University of Mons, Mons, Belgium
