[en] This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Costa, Joana ; REQUIMTE-LAQV/Faculdade de Farmácia Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal. jbcosta@ff.up.pt.
Bavaro, Simona Lucia ; Institute of Sciences of Food Production (ISPA) - National Research Council (CNR), Bari, Italy. ; Moorepark Food Research Centre, Teagasc, Fermoy, Co. Cork, Ireland.
Benedé, Sara ; Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain.
Diaz-Perales, Araceli ; Centro de Biotecnologia y Genomica de Plantas (UPM-INIA), Universidad Politecnica de Madrid, Pozuelo de Alarcon, Madrid, Spain.
Bueno-Diaz, Cristina ; Departmento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas de la Universidad Complutense de Madrid, Madrid, Spain.
Gelencser, Eva; Department of Biology, Food Science Research Institute, National Agricultural Research and Innovation Centre, Budapest, Hungary.
Klueber, Julia; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. ; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense C, Denmark.
Larré, Colette ; INRAE, UR 1268, Biopolymers Interactions Assemblies, Nantes, France.
Lozano-Ojalvo, Daniel ; Precision Immunology Institute, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lupi, Roberta ; INRAE, UR 1268, Biopolymers Interactions Assemblies, Nantes, France.
Mafra, Isabel ; REQUIMTE-LAQV/Faculdade de Farmácia Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.
Mazzucchelli, Gabriel ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Molina, Elena ; Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain.
Monaci, Linda ; Institute of Sciences of Food Production (ISPA) - National Research Council (CNR), Bari, Italy.
Martín-Pedraza, Laura ; Biochemistry and Molecular Biology department, Chemistry Faculty, Complutense University of Madrid, 28040, Madrid, Spain.
Piras, Cristian; Department of Veterinary Medicine, University of Milan, Milan, Italy. ; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Rodrigues, Pedro M ; CCMAR, Universidade do Algarve, Campus de Gambelas, Faro, Portugal.
Roncada, Paola; Department of Health Sciences, University 'Magna Græcia', Catanzaro, Italy.
Schrama, Denise ; CCMAR, Universidade do Algarve, Campus de Gambelas, Faro, Portugal.
Cirkovic-Velickovic, Tanja ; University of Belgrade - Faculty of Chemistry, Belgrade, Serbia. ; Ghent University Global Campus, Yeonsu-gu, Incheon, South Korea. ; Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
Verhoeckx, Kitty ; Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
Villa, Caterina ; REQUIMTE-LAQV/Faculdade de Farmácia Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.
Kuehn, Annette ; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Hoffmann-Sommergruber, Karin ; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Holzhauser, Thomas ; Division of Allergology Paul-Ehrlich-Institut, Langen, Germany.
Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?
Publication date :
February 2022
Journal title :
Clinical Reviews in Allergy and Immunology
ISSN :
1080-0549
eISSN :
1559-0267
Publisher :
Humana Press, Us
Volume :
62
Issue :
1
Pages :
37-63
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
PRIDE/11012546/NEXTIMMUNE/Fonds National de la Recherche Luxembourg/; APSIS, PMC/2017/02/Personalised Medicine Consortium, Luxembourg/; UIDB 50006/2020/Fundação para a Ciência e a Tecnologia/; PTDC/BAA-AGR/31720/2017/Fundação para a Ciência e a Tecnologia/; NORTE-01-0145-FEDER-00001/Fundação para a Ciência e a Tecnologia/; PD/BD/114576/2016/Fundação para a Ciência e a Tecnologia/; UIDB/04326/2020/Fundação para a Ciência e a Tecnologia/; Mar2020 16-02-01-FMP-0014/Fundação para a Ciência e a Tecnologia/; OI172024/Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (RS)/; COST Action FA1402/European Cooperation in Science and Technology/
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