[en] Current approaches based on electrophoretic, chromatographic or immunochemical principles have allowed characterizing multiple allergens, mapping their epitopes, studying their mechanisms of action, developing detection and diagnostic methods and therapeutic strategies for the food and pharmaceutical industry. However, some of the common structural features related to the allergenic potential of food proteins remain unknown, or the pathological mechanism of food allergy is not yet fully understood. In addition, it is also necessary to evaluate new allergens from novel protein sources that may pose a new risk for consumers. Technological development has allowed the expansion of advanced technologies for which their whole potential has not been entirely exploited and could provide novel contributions to still unexplored molecular traits underlying both the structure of food allergens and the mechanisms through which they sensitize or elicit adverse responses in human subjects, as well as improving analytical techniques for their detection. This review presents cutting-edge instrumental techniques recently applied when studying structural and functional aspects of proteins, mechanism of action and interaction between biomolecules. We also exemplify their role in the food allergy research and discuss their new possible applications in several areas of the food allergy field.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Benedé, Sara ; Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
Lozano-Ojalvo, Daniel ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, NY, USA.
Cristobal, Susana ; Department of Biomedical and Clinical Sciences, Cell Biology, Faculty of Medicine, Linköping University, Linköping, Sweden. ; IKERBASQUE, Basque Foundation for Science, Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.
Costa, Joana ; REQUIMTE-LAQV, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
D'Auria, Enza; Clinica Pediatrica, Ospedale dei Bambini Vittore Buzzi, Università degli Studi, Milano, Italy.
Velickovic, Tanja Cirkovic ; Faculty of Chemistry, University of Belgrade, Belgrade, Serbia. ; Ghent University Global Campus, Incheon, South Korea. ; Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. ; Serbian Academy of Sciences and Arts, Belgrade, Serbia.
Garrido-Arandia, María ; Centro de Biotecnología y Genómica de Plantas (UPM-INIA), Universidad Politécnica de Madrid, Pozuelo de Alarcón, Madrid, Spain.
Karakaya, Sibel ; Department of Food Engineering, Ege University, Izmir, Turkey.
Mafra, Isabel ; REQUIMTE-LAQV, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Mazzucchelli, Gabriel ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Picariello, Gianluca ; Institute of Food Sciences, National Research Council (CNR), Avellino, Italy.
Romero-Sahagun, Alejandro; Centro de Biotecnología y Genómica de Plantas (UPM-INIA), Universidad Politécnica de Madrid, Pozuelo de Alarcón, Madrid, Spain.
Villa, Caterina ; REQUIMTE-LAQV, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Roncada, Paola ; Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.
Molina, Elena ; Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
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