EPS-229 : Polymeric Micelles as Drug Delivery System for PARP Inhibitor-Based Chemo-Radiotherapy Combination Against Triple-Negative Breast Cancer - 2023
[en] Poly (ADP-ribose) polymerase inhibitors
(PARPi) are commonly used in the treatment against
BRCA-mutated (BRCAmut) tumors, such as triple negative breast
cancer (TNBC). However, PARPi-based monotherapies have some
inherent limitations, including the development of resistance.
To overcome some of these drawbacks, combinations of PARPi
with different chemotherapeutics or other cancer treatments
(e.g., radiotherapy) have shown significant promise. We have
previously established a therapeutic approach against BRCAmut
TNBC, based on combining the DNA damage response inhibition
of PARPi with the radiotherapeutic effect of the Auger electron
emitter 125-iodine (125I). Yet, preliminary preclinical evaluation
showed poor biodistribution and chemical instability of the
developed 125I-PARPi tracer. Hence, we here set out to develop a
polymeric micelle-based formulation efficiently co-encapsulating
non-radioactive and radioactive I-PARPi with the overall aim
of improving tracer stability, biodistribution and target-site
accumulation for more efficient chemo-internal radiotherapy
combination.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Schäfer, Laura; RWTH Aachen University Hospital > Department of Nuclear Medicine
Wang, Alec; RWTH Aachen University > Institute for Experimental Molecular Imaging
Peña, Joaquin; RWTH Aachen University > Institute for Experimental Molecular Imaging
Henrard, Elea ; RWTH Aachen University > Department of Nuclear Medicine
Lammers, Twan; RWTH Aachen University > Institute for Experimental Molecular Imaging ; RWTH Aachen University > Center for Integrated Oncology (CIO)
Buhl, Eva Miriam; RWTH Aachen University > Institute of Pathology > Electron Microscopy Facility
Frings, Markus; RWTH Aachen University > Institute of Organic Chemistry
Bolm, Carsten; RWTH Aachen University > Institute of Organic Chemistry
Morgenroth, Agnieszka; RWTH Aachen University > Department of Nuclear Medicine
Mottaghy, Felix; RWTH Aachen University > Department of Nuclear Medicine ; RWTH Aachen University > Center for Integrated Oncology (CIO) ; UM - University of Maastricht > Department of Radiology and Nuclear Medicine
Language :
English
Title :
EPS-229 : Polymeric Micelles as Drug Delivery System for PARP Inhibitor-Based Chemo-Radiotherapy Combination Against Triple-Negative Breast Cancer
Original title :
[en] Correction to: EANM'23 Abstract Book Congress Sep 9-13, 2023.
Publication date :
December 2023
Journal title :
European Journal of Nuclear Medicine and Molecular Imaging
