Adult intensive care; Cardiovascular system; Drug interactions; Drugs and medicines; Toxicology; Fat Emulsions, Intravenous; prothipendyl; Antipsychotic Agents; Humans; Fat Emulsions, Intravenous/therapeutic use; Medicine (all)
Abstract :
[en] Prothipendyl, a lipophilic neuroleptic drug, requires a careful dosage regimen due to its potential side effects, including life-threatening arrhythmias.This report outlines a case of severe prothipendyl intoxication, its management and the successful utilisation of Intralipid, an intravenous lipid emulsion, in treating ventricular arrhythmia postmassive prothipendyl ingestion. Additionally, the mechanism of action of Intralipid and the rebound concentration of the lipophilic drug in such scenarios are discussed.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Meunier, Anne; Anesthesia and Intensive Care, Montlegia Hospital, Groupe Santé CHC, Liège, Belgium
Goffin, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation ; Anesthesia and Intensive Care, Montlegia Hospital, Groupe Santé CHC, Liège, Belgium goffin.pjc@gmail.com
Deville, Marine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de toxicologie clinique, médicolégale, environnementale et en entreprise
Demaret, Pierre; Anesthesia and Intensive Care, Montlegia Hospital, Groupe Santé CHC, Liège, Belgium
Language :
English
Title :
Intravenous lipid emulsion for a life-threatening prothipendyl intoxication.
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