Infectious diseases; clinical trials; everyday functioning; quality of life
Abstract :
[en] OBJECTIVE: A subset of COVID-19 patients continues to experience cognitive difficulties 24 months post-infection. The factors driving these symptoms are complex, and the underlying pathophysiology is unclear. This study aimed to characterize individuals with Long COVID reporting cognitive issues.
METHOD: One hundred twenty-three patients underwent a comprehensive neuropsychological evaluation resulting from the baseline of an RCT study (COVCOG), along with questionnaires assessing cognitive complaints, fatigue, sleep difficulties, quality of life, psychological distress, and impact on daily activities. Latent Profile Analyses on cognitive scores were conducted to investigate the presence of different patient profiles. Robust analyses of variance and Pearson's chi-square examined the profiles' effects on demographic variables and questionnaire scores.
RESULTS: Patients had had predominantly mild to moderate infections (87.8%) and were assessed an average of 20.9 (±8.6) months post-infection. Neuropsychological assessment showed cognitive impairment in at least one domain in 72% of the patients, mainly in attention and executive functions. Over 80% reported sleep problems and fatigue, 97% concentration problems, and some 80% memory and word-finding problems. The self-report questionnaires also revealed significant complaints. Three profiles emerged (all ps < .001). Profiles 1 and 2 both experienced widespread cognitive issues; Profile 1 patients expressed more complaints about cognitive functioning and daily fatigue (all ps < .045). Patients in Profile 3 were more frequently men (all ps < .049) with a specific impairment of verbal long-term memory and fewer complaints.
CONCLUSIONS: The study identifies three different profiles of individuals with Long COVID, highlighting the need for comprehensive evaluations including neuropsychological, psychological, somatic, and functional aspects to implement effective, tailored interventions. Clinicaltrials.gov: NCT05167266.
Disciplines :
Neurosciences & behavior
Author, co-author :
Cabello Fernandez, Carmen ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog)
Didone, Vincent ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog)
Slama, Hichem; Department of Neuropsychology and Speech Therapy, Erasme Hospital, ULB, Brussels, Belgium ; UR2NF-Neuropsychology and Functional Neuroimaging Research Group at CRCN-Research Centre in Cognitive Neurosciences, ULB, Brussels, Belgium
Dupuis, Gilles; Department of Psychology, UQAM, Montreal, Québec, Canada
Fery, Patrick; Department of Neuropsychology and Speech Therapy, Erasme Hospital, ULB, Brussels, Belgium
Delrue, Gaël ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte
Lesoinne, Alexia ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Aging & Memory
Collette, Fabienne ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Aging & Memory ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) > Cognition et Langage
Willems, Sylvie ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog)
Language :
English
Title :
Profiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.
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