EQ‐5D; asthma; digital health; rhinitis; visual analogue scale; Immunology and Allergy; Immunology; Pulmonary and Respiratory Medicine
Abstract :
[en] Patient-reported outcome measures (PROMs) are used to assess a patient's health status at a particular point in time. They are essential in the development of person-centred care. This paper reviews studies performed on PROMs for assessing AR and asthma control, in particular VAS scales that are included in the app MASK-air® (Mobile Airways Sentinel networK) for asthma and rhinitis. VASs were initially developed on paper and pencil and tested for their criterion validity, cut-offs and responsiveness. Then, a multicentric, multinational, double-blind, placebo-controlled, randomised control trial (DB-PC-RCT) using an electronic VAS form was carried out. Finally, with the development of MASK-air® in 2015, previously validated VAS questions were adapted to the digital format and further methodologic evaluations were performed. VAS for asthma, rhinitis, conjunctivitis, work and EQ-5D are included in the app. Additionally, two control-medication scores for allergic symptoms of asthma (e-DASTHMA) were validated for their criterion validity, cut-offs and responsiveness.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bousquet, Jean ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany ; ARIA, Montpellier, France
Sousa-Pinto, Bernardo; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Anto, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain ; Universitat Pompeu Fabra (UPF), Barcelona, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Bedbrook, Anna; ARIA, Montpellier, France
Czarlewski, Wienczyslawa; ARIA, Montpellier, France ; Medical Consulting Czarlewski, Levallois, France
Ansotegui, Ignacio J; Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
Bergmann, Karl-C ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
Braido, Fulvio; Respiratory and Allergy Clinic, IRCCS - Policlinico San Martino and Department of Internal Medicine (DIMI), University of Genoa, Genoa, Italy
Brussino, Luisa; Department of Medical Sciences, University of Torino, Torino, Italy ; Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy
Cecchi, Lorenzo; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
Loureiro, Claudia Chaves; Department of Pneumology and University of Coimbra, Medicine Faculty, Coimbra, Portugal ; Coimbra Institute for Clinical and Biomedical Research, CIBB, Coimbra, Portugal
Cruz, Alvaro A; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
Devillier, Philippe; VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France
Fiocchi, Alessandro ; Allergy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy
Gemicioglu, Bilun; Department of Pulmonary Diseases and Institute of Pulmonology and Tuberculosis, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey
Haahtela, Tari; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Ivancevich, Juan Carlos; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
Klimek, Ludger; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany ; Center for Rhinology and Allergology, Wiesbaden, Germany
Kulus, Marek; Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland
Kuna, Piotr; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kupczyk, Maciej; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kvedariene, Violeta; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania ; Department of Pathology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Larenas-Linnemann, Desiree E ; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Louis, Gilles ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Makris, Michael; Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece
Morais-Almeida, Mario; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
Niedoszytko, Marek; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Ohta, Ken; Japan Antituberculosis Association (JATA) Fukujuji Hospital, Tokyo, Japan ; National Hospital Organization Tokyo National Hospital, and JATA Fukujuji Hospital, Tokyo, Japan
Ollert, Markus ; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg ; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark
Papadopoulos, Nikolaos; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Patella, Vincenzo; Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Salerno, Italy ; Agency of Health ASL, Salerno, Italy ; Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy
Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés
Pfaar, Oliver ; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Puggioni, Francesca; IRCCS Humanitas Research Center, Personalized Medicine Asthma & Allergy, Milan, Italy
Quirce, Santiago; Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain
Regateiro, Frederico S; Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal ; Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine, University of Coimbra, Coimbra, Portugal ; Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Roche, Nicolas; Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France ; UMR 1016, Institut Cochin, Paris, France
Rouadi, Philip W; Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon ; Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait
Samolinski, Boleslaw; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Sastre, Joaquin; Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain
Schleich, Florence ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation
Scichilone, Nicola; PROMISE Department, University of Palermo, Palermo, Italy
Taborda-Barata, Luis; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal ; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Toppila-Salmi, Sanna ; Department of Otorhinolaryngology, University of Eastern Finland and the North Savo Wellbeing Services County, Kuopio, Finland ; Department of Allergy, Inflammation Center, Skin and Allergy Hospital, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Valiulis, Arunas; Clinic of Asthma, Allergy, and Chronic Lung Diseases, Vilnius, Lithuania ; Interdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine, Institute of Health Sciences, and Clinic of Children's Diseases, Medical Faculty of Vilnius University, Vilnius, Lithuania
Vardaloglu Koyuncu, Ilgim; Department of Pulmonary Diseases and Institute of Pulmonology and Tuberculosis, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey
Ventura, Maria Teresa ; University of Bari Medical School, Bari, Italy ; Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy
Yorgancioglu, Arzu; Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
Fonseca, Joao A; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Zuberbier, Torsten ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
This work has received funding from ARIA and the European Union's Horizon Europe research and innovation programme under Grant Agreement No 101057131, Climate Action To Advance HeaLthY Societies in Europe (CATALYSE). MASK-air\u00AE has been supported by EU grants (POLLAR, EIT Health; Structural and Development Funds, Twinning, EIP on AHA and H2020), and educational grants from Mylan-Viatris, ALK, GSK, Novartis, Stallerg\u00E8nes-Greer and Uriach. Jean Bousquet developed the concept of the paper, was involved in all reported studies and wrote the paper. Bernardo Sousa-Pinto, Josep M. Anto, Joao A. Fonseca, Torsten Zuberbier had a major role in MASK-air studies. Anna Bedbrook and Wienczyslawa Czarlewski had a major role in all studies. Ignacio J. Ansotegui, Karl-C. Bergmann, Fulvio Braido, Luisa Brussino, Lorenzo Cecchi, Claudia Chaves Loureiro, Alvaro A. Cruz, Philippe Devillier, Alessandro Fiocchi, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Ludger Klimek, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Desiree E. Larenas-Linnemann, Gilles Louis, Renaud Louis, Michael Makris, Mario Morais-Almeida, Marek Niedoszytko, Ken Ohta, Markus Ollert, Nikolaos Papadopoulos, Vincenzo Patella, Benoit P\u00E9tr\u00E9, Oliver Pfaar, Francesca Puggioni, Santiago Quirce, Frederico S. Regateiro, Nicolas Roche, Philip W. Rouadi, Boleslaw Samolinski, Joaquin Sastre, Florence Schleich, Nicola Scichilone, Luis Taborda-Barata, Sanna Toppila-Salmi, Arunas Valiulis, Ilgim Vardaloglu Koyuncu, Maria Teresa Ventura, 0 Arzu Yorgancioglu participated to the studies and the discussion of the paper. All authors agreed with the contents of the paper and participated in the writing of the study. Open Access funding enabled and organised by Projekt DEAL.This work has received funding from ARIA and the European Union's Horizon Europe research and innovation programme under Grant Agreement No 101057131, Climate Action To Advance HeaLthY Societies in Europe (CATALYSE). MASK\u2010air has been supported by EU grants (POLLAR, EIT Health; Structural and Development Funds, Twinning, EIP on AHA and H2020), and educational grants from Mylan\u2010Viatris, ALK, GSK, Novartis, Stallerg\u00E8nes\u2010Greer and Uriach. Jean Bousquet developed the concept of the paper, was involved in all reported studies and wrote the paper. Bernardo Sousa\u2010Pinto, Josep M. Anto, Joao A. Fonseca, Torsten Zuberbier had a major role in MASK\u2010air studies. Anna Bedbrook and Wienczyslawa Czarlewski had a major role in all studies. Ignacio J. Ansotegui, Karl\u2010C. Bergmann, Fulvio Braido, Luisa Brussino, Lorenzo Cecchi, Claudia Chaves Loureiro, Alvaro A. Cruz, Philippe Devillier, Alessandro Fiocchi, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Ludger Klimek, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Desiree E. Larenas\u2010Linnemann, Gilles Louis, Renaud Louis, Michael Makris, Mario Morais\u2010Almeida, Marek Niedoszytko, Ken Ohta, Markus Ollert, Nikolaos Papadopoulos, Vincenzo Patella, Benoit P\u00E9tr\u00E9, Oliver Pfaar, Francesca Puggioni, Santiago Quirce, Frederico S. Regateiro, Nicolas Roche, Philip W. Rouadi, Boleslaw Samolinski, Joaquin Sastre, Florence Schleich, Nicola Scichilone, Luis Taborda\u2010Barata, Sanna Toppila\u2010Salmi, Arunas Valiulis, Ilgim Vardaloglu Koyuncu, Maria Teresa Ventura, Arzu Yorgancioglu participated to the studies and the discussion of the paper. All authors agreed with the contents of the paper and participated in the writing of the study.
Basch E, Barbera L, Kerrigan CL, Velikova G. Implementation of patient-reported outcomes in routine medical care. Am Soc Clin Oncol Educ Book. 2018;38:122-134. https://doi.org/10.1200/EDBK_200383
Weldring T, Smith SM. Patient-reported outcomes (PROs) and patient-reported outcome measures (PROMs). Health Serv Insights. 2013;6:61-68. https://doi.org/10.4137/HSI.S11093
Klimek L, Bergmann KC, Biedermann T, et al. Visual analogue scales (VAS): measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care: position paper of the German society of allergology (AeDA) and the German society of allergy and clinical immunology (DGAKI), ENT section, in collaboration with the working group on clinical immunology, allergology and environmental medicine of the German society of otorhinolaryngology, head and neck surgery (DGHNOKHC). Allergo J Int. 2017;26(1):16-24. https://doi.org/10.1007/s40629-016-0006-7
Ferraz MB, Quaresma MR, Aquino LR, Atra E, Tugwell P, Goldsmith CH. Reliability of pain scales in the assessment of literate and illiterate patients with rheumatoid arthritis. J Rheumatol. 1990;17(8):1022-1024.
Price DD, McGrath PA, Rafii A, Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 1983;17(1):45-56.
Langley GB, Sheppeard H. The visual analogue scale: its use in pain measurement. Rheumatol Int. 1985;5(4):145-148.
Kelly AM. The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. Emerg Med J. 2001;18(3):205-207.
Kersten P, White PJ, Tennant A. Is the pain visual analogue scale linear and responsive to change? An exploration using Rasch analysis. PLoS One. 2014;9(6):e99485. https://doi.org/10.1371/journal.pone.0099485
Devillier P, Bousquet PJ, Grassin-Delyle S, et al. Comparison of outcome measures in allergic rhinitis in children, adolescents and adults. Pediatr Allergy Immunol. 2016;27(4):375-381. https://doi.org/10.1111/pai.12561
Devillier P, Bousquet J, Salvator H, Naline E, Grassin-Delyle S, de Beaumont O. In allergic rhinitis, work, classroom and activity impairments are weakly related to other outcome measures. Clin Exp Allergy. 2016;46(11):1456-1464. https://doi.org/10.1111/cea.12801
Bousquet PJ, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines. Allergy. 2007;62(4):367-372. https://doi.org/10.1111/j.1398-9995.2006.01276.x
Bousquet J, Bodez T, Gehano P, et al. Implementation of guidelines for allergic rhinitis in specialist practices. A randomized pragmatic controlled trial. Int Arch Allergy Immunol. 2009;150(1):75-82. https://doi.org/10.1159/000210383
Bousquet PJ, Combescure C, Klossek JM, Daures JP, Bousquet J. Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis. J Allergy Clin Immunol. 2009;123(6):1349-1354. https://doi.org/10.1016/j.jaci.2009.02.033
Bousquet PJ, Bachert C, Canonica GW, et al. Uncontrolled allergic rhinitis during treatment and its impact on quality of life: a cluster randomized trial. J Allergy Clin Immunol. 2010;126(3):666e1-5-668e1-5. https://doi.org/10.1016/j.jaci.2010.06.034
Bousquet PJ, Demoly P, Devillier P, Mesbah K, Bousquet J. Impact of allergic rhinitis symptoms on quality of life in primary care. Int Arch Allergy Immunol. 2013;160(4):393-400. https://doi.org/10.1159/000342991
Demoly P, Bousquet PJ, Mesbah K, Bousquet J, Devillier P. Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care: asthma and Rhinitis. Clin Exp Allergy. 2013;43(8):881-888. https://doi.org/10.1111/cea.12121
Bousquet PJ, Devillier P, Tadmouri A, Mesbah K, Demoly P, Bousquet J. Clinical relevance of cluster analysis in phenotyping allergic rhinitis in a real-life study. Int Arch Allergy Immunol. 2015;166(3):231-240. https://doi.org/10.1159/000381339
Ohta K, Bousquet PJ, Aizawa H, et al. Prevalence and impact of rhinitis in asthma. SACRA, a cross-sectional nation-wide study in Japan. Research Support, Non-U.S. Gov't. Allergy. 2011;66(10):1287-1295. https://doi.org/10.1111/j.1398-9995.2011.02676.x
Ohta K, Jean Bousquet P, Akiyama K, et al. Visual analog scale as a predictor of GINA-defined asthma control. The SACRA study in Japan. Multicenter StudyResearch Support, Non-U.S. Gov't. J Asthma. 2013;50(5):514-521. https://doi.org/10.3109/02770903.2013.786726
Hojo M, Ohta K, Iikura M, Mizutani T, Hirashima J, Sugiyama H. Clinical usefulness of a guideline-based screening tool for the diagnosis of allergic rhinitis in asthmatics: the Self Assessment of Allergic Rhinitis and Asthma questionnaire. Respirology. 2013;18(6):1016-1021. https://doi.org/10.1111/resp.12116
Bousquet J, Bachert C, Canonica GW, et al. Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study. Allergy. 2009;64(10):1516-1523. https://doi.org/10.1111/j.1398-9995.2009.02115.x
Bousquet J, Bachert C, Canonica GW, et al. Efficacy of desloratadine in persistent allergic rhinitis - a GA(2)LEN study. Int Arch Allergy Immunol. 2010;153(4):395-402. https://doi.org/10.1159/000316351
Bahbah F, Gentil C, Sousa-Pinto B, et al. Patient-reported outcome measures in birch pollen allergic patients treated with sublingual immunotherapy reflect real life. Allergy. 2023;78(4):1113-1116. https://doi.org/10.1111/all.15550
Bousquet J, Schunemann HJ, Fonseca J, et al. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy. 2015;70(11):1372-1392. https://doi.org/10.1111/all.12686
EQ-5D-5L. 2023. Accessed September 9, 2024. https://euroqol.org/information-and-support/euroqol-instruments/eq-5d-5l/
Sousa-Pinto B, Azevedo LF, Jutel M, et al. Development and validation of combined symptom-medication scores for allergic rhinitis. Allergy. 2022;77(7):2147-2162. https://doi.org/10.1111/all.15199
Murray JJ, Nathan RA, Bronsky EA, Olufade AO, Chapman D, Kramer B. Comprehensive evaluation of cetirizine in the management of seasonal allergic rhinitis: impact on symptoms, quality of life, productivity, and activity impairment. Allergy Asthma Proc. 2002;23(6):391-398.
Bedard A, Anto JM, Fonseca JA, et al. Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air((R)) App. Allergy. 2020;75(7):1672-1688. https://doi.org/10.1111/all.14204
Vieira RJ, Pham-Thi N, Anto JM, et al. Academic productivity of young people with allergic rhinitis: a MASK-air study. J Allergy Clin Immunol Pract. 2022;10(11):3008e4-3017e4. https://doi.org/10.1016/j.jaip.2022.08.015
Devlin NJ, Brooks R. EQ-5D and the EuroQol group: past, present and future. Appl Health Econ Health Pol. 2017;15(2):127-137. https://doi.org/10.1007/s40258-017-0310-5
Sousa-Pinto B, Fonseca JA, Gemicioglu B, et al. Patient-reported outcome measures (PROMs) using the MASK-air(R) app in severe asthma. Allergy. 2022;77(5):1600-1602. https://doi.org/10.1111/all.15248
Benfante A, Sousa-Pinto B, Pillitteri G, et al. Applicability of the MASK-air((R)) app to severe asthma treated with biologic molecules: a pilot study. Int J Mol Sci. 2022;23(19). https://doi.org/10.3390/ijms231911470
Bousquet J, Khaltaev N, Cruz AA, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy. 2008;63((Suppl 86)):8-160. https://doi.org/10.1111/j.1398-9995.2007.01620.x
Fokkens W, Vinge I, Zuberbier T, Bousquet J. Improvement in sleep quality and daily functioning correlate with reduced congestion in subjects with persistent allergic rhinitis treated with desloratadine 5 mg daily: results from the Aerius Control: clinical and Evaluative Profile of Treatment-2 (ACCEPT2) trial in collaboration with Global Allergy and Asthma European Network. Allergy. 2009;64(Suppl 90):593.
Bousquet J, Zuberbier T, Mullol J, ACCEPT-1 Study Group icwGL. Improvement in disease-specific quality of life and reduced symptom burden measured with a visual analogue scale in subjects with intermittent allergic rhinitsi treated with desloratadine. Allergy. 2008;62(Suppl 64).
Worm M, Rak S, de Blay F, et al. Sustained efficacy and safety of a 300IR daily dose of a sublingual solution of birch pollen allergen extract in adults with allergic rhinoconjunctivitis: results of a double-blind, placebo-controlled study. Clin Transl Allergy. 2014;4(1):7. https://doi.org/10.1186/2045-7022-4-7
Bousquet J, VanCauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2002;108(5 Suppl l):S147-S334.
Bousquet J, Anto JM, Sousa-Pinto B, et al. Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: the ARIA-MASK-air((R)) approach. Clin Transl Allergy. 2023;13(1):e12215. https://doi.org/10.1002/clt2.12215
Bousquet J, Bedbrook A, Czarlewski W, et al. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma. Clin Transl Allergy. 2019;9:16. https://doi.org/10.1186/s13601-019-0252-0
Bousquet J, Dahl R, Khaltaev N. Global alliance against chronic respiratory diseases. Allergy. 2007;62(3):216-223. https://doi.org/10.1111/j.1398-9995.2007.01307.x
Bousquet J, Burney PG, Zuberbier T, et al. GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic. Allergy. 2009;64(7):969-977. https://doi.org/10.1111/j.1398-9995.2009.02059.x
Bousquet J, Anto J, Auffray C, et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy. 2011;66(5):596-604. https://doi.org/10.1111/j.1398-9995.2010.02534.x
Anto JM, Bousquet J, Akdis M, et al. Mechanisms of the development of allergy (MeDALL): introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol. 2017;139(2):388-399. https://doi.org/10.1016/j.jaci.2016.12.940
Bousquet J, Illario M, Farrell J, et al. The reference site collaborative network of the European innovation partnership on active and healthy ageing. Transl Med UniSa. 2019;19:66-81.
Bousquet J, Agache I, Aliberti MR, et al. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - reference Site Twinning (EIP on AHA). Allergy. 2017;73(1):77-92. https://doi.org/10.1111/all.13218
Bousquet J, Bedbrook A, Czarlewski W, et al. Digital Health Europe (DHE) Twinning on severe asthma-kick-off meeting report. J Thorac Dis. 2021;13(5):3215-3225. https://doi.org/10.21037/jtd-21-792
Bousquet J, Anto JM, Annesi-Maesano I, et al. POLLAR: impact of air POLLution on asthma and rhinitis; a European Institute of innovation and Technology health (EIT health) project. Clin Transl Allergy. 2018;8:36. https://doi.org/10.1186/s13601-018-0221-z
Sousa-Pinto B, Jacome C, Pereira AM, et al. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study. Lancet Digit Health. 2023;5(4):e227-e238. https://doi.org/10.1016/S2589-7500(23)00020-1
Bousquet J, Samolinski B, Kaidashev I, et al. UCRAID (Ukrainian Citizen and refugee electronic support in Respiratory diseases, Allergy, Immunology and Dermatology) action plan. Allergy. 2023;78(10):2581-2595. https://doi.org/10.1111/all.15855
Bousquet J, Shamji MH, Anto JM, et al. Patient-centered digital biomarkers for allergic respiratory diseases and asthma: the ARIA-EAACI approach - ARIA-EAACI Task Force Report. Allergy. 2023;78(7):1758-1776. https://doi.org/10.1111/all.15740
Anto A, Sousa-Pinto B, Czarlewski W, et al. Automatic market research of mobile health apps for the self-management of allergic rhinitis. Clin Exp Allergy. 2022;52(10):1195-1207. https://doi.org/10.1111/cea.14135
Bousquet J, Anto J, Sousa-Pinto B, et al. Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: the ARIA-MASK-air® approach. Clin Transl Allergy. 2023:e12215.
Price DD, McGrath PA, Rafii A, Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 1983;17(1):45-56. https://doi.org/10.1016/0304-3959(83)90126-4
Bousquet J, Anto JM, Bachert C, et al. ARIA digital anamorphosis: digital transformation of health and care in airway diseases from research to practice. Allergy. 2021;76(1):168-190. https://doi.org/10.1111/all.14422
Ventura MT, Giuliano AFM, Buquicchio R, et al. Implementation of the MASK-air(R) app for rhinitis and asthma in older adults: MASK@Puglia pilot study. Int Arch Allergy Immunol. 2022;183(1):45-50. https://doi.org/10.1159/000518032
Kvedariene V, Biliute G, Didziokaite G, et al. Mobile health app for monitoring allergic rhinitis and asthma in real life in Lithuanian MASK-air users. Clin Transl Allergy. 2022;12(9):e12192. https://doi.org/10.1002/clt2.12192
Szylling A, Raciborski F, Wojas O, et al. Why the role of mHealth in allergy diagnosis and treatment adherence cannot be overlooked. Clin Transl Allergy. 2023;13(10):e12298. https://doi.org/10.1002/clt2.12298
Taborda-Barata L, Ventura MT, Blain H, et al. MASK-air((R)) real-world data in respiratory allergy in old-age adults. Clin Transl Allergy. 2023;13(1):e12216. https://doi.org/10.1002/clt2.12216
Sousa-Pinto B, Sa-Sousa A, Vieira RJ, et al. Cut-off values of MASK-air(R) patient-reported outcome measures (PROMs). J Allergy Clin Immunol Pract. 2022. https://doi.org/10.1016/j.jaip.2022.12.005
Sofiev M, Palamarchuk Y, Bedard A, et al. A demonstration project of global alliance against chronic respiratory diseases: prediction of interactions between air pollution and allergen exposure-the mobile airways Sentinel NetworK-impact of air POLLution on asthma and rhinitis approach. Chin Med J. 2020;133(13):1561-1567. https://doi.org/10.1097/CM9.0000000000000916
Vardaloglu I, Sousa-Pinto B, Bousquet J, et al. In symptomatic patients on as-needed inhaled corticosteroids-formoterol, VAS asthma is associated with small airways resistance. J Asthma. 2023:1-8. https://doi.org/10.1080/02770903.2023.2248485
Sastre J, Del Cuvillo A, Colas C, et al. Validation of the MASK-air App for assessment of allergic rhinitis. Allergy. 2020;75(11):2958-2961. https://doi.org/10.1111/all.14415
Sousa-Pinto B, Sa-Sousa A, Vieira RJ, et al. Cutoff values of MASK-air patient-reported outcome measures. J Allergy Clin Immunol Pract. 2023;11(4):1281e5-1289e5. https://doi.org/10.1016/j.jaip.2022.12.005
Langley GB, Sheppeard H. The visual analogue scale: its use in pain measurement. Rheumatol Int. 1985;5(4):145-148. https://doi.org/10.1007/bf00541514
Sousa-Pinto B, Azevedo LF, Sa-Sousa A, et al. Allergen immunotherapy in MASK-air users in real-life: results of a Bayesian mixed-effects model. Clin Transl Allergy. 2022;12(3):e12128. https://doi.org/10.1002/clt2.12128
Sousa-Pinto B, Louis G, Rodrigues J, et al. Impairment of EQ-5D-5L domains according to allergic rhinitis and asthma control: a MASK-air real-world study. J Allergy Clin Immunol Pract. 2023. https://doi.org/10.1016/j.jaip.2023.08.006
Bousquet J, Sousa-Pinto B, Regateiro FS, et al. MASK-air(R) direct patient data support the ARIA-MeDALL hypothesis on allergic phenotypes. Allergy. 2023. https://doi.org/10.1111/all.15842
Bousquet J, Sousa-Pinto B, Shamji MH, et al. Improvement of daily allergy control by sublingual immunotherapy: a MASK-air(R) study. Clin Exp Allergy. 2023. https://doi.org/10.1111/cea.14318
Sousa-Pinto B, Schunemann HJ, Sa-Sousa A, et al. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: the MASK-air(R) longitudinal study. Allergy. 2023;78(4):968-983. https://doi.org/10.1111/all.15574
Amaral R, Jacome C, Almeida R, et al. Profiling persistent asthma phenotypes in adolescents: a longitudinal diagnostic evaluation from the INSPIRERS studies. Int J Environ Res Publ Health. 2021;18(3). https://doi.org/10.3390/ijerph18031015
Sousa-Pinto B, Louis R, Anto JM, et al. Adherence to inhaled corticosteroids and long-acting beta2-agonists in asthma: a MASK-air study. Pulmonology. 2023;S2531-0437(23):001307. https://doi.org/10.1016/j.pulmoe.2023.07.004
Vieira RJ, Sousa-Pinto B, Cardoso-Fernandes A, et al. Control of Allergic Rhinitis and Asthma Test: a systematic review of measurement properties and COSMIN analysis. Clin Transl Allergy. 2022;12(9):e12194. https://doi.org/10.1002/clt2.12194
Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993;4(5):353-365.
Prasad M, Wahlqvist P, Shikiar R, Shih YC. A review of self-report instruments measuring health-related work productivity: a patient-reported outcomes perspective. Pharmacoeconomics. 2004;22(4):225-244. https://doi.org/10.2165/00019053-200422040-00002
Kelly AM. The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. Emerg Med J. 2001;18(3):205-207. https://doi.org/10.1136/emj.18.3.205
Bousquet J, Bewick M, Arnavielhe S, et al. Work productivity in rhinitis using cell phones: the MASK pilot study. Allergy. 2017;72(10):1475-1484. https://doi.org/10.1111/all.13177
Bousquet J, Arnavielhe S, Bedbrook A, et al. Mask 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence. Clin Transl Allergy. 2018;8:45. https://doi.org/10.1186/s13601-018-0227-6
Sousa-Pinto B, Eklund P, Pfaar O, et al. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK-air(R). Clin Transl Allergy. 2021;11(7):e12062. https://doi.org/10.1002/clt2.12062
Leynaert B, Neukirch C, Liard R, Bousquet J, Neukirch F. Quality of life in allergic rhinitis and asthma. A population-based study of young adults. Am J Respir Crit Care Med. 2000;162(4 Pt 1):1391-1396.
Mitsias DI, Dimou MV, Lakoumentas J, et al. Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes. Clin Transl Allergy. 2020;10:9. https://doi.org/10.1186/s13601-020-00313-2
