[en] The gut microbiome plays a significant role in regulating gastrointestinal (GI) function and modulating the gut-brain axis, which describes the bidirectional communication between the GI tract and the central nervous system (CNS). Its involvement in digestion, immunity, and neurophysiology is well recognized. This study offers novel insights by focusing on psychobiotics, a class of probiotics with targeted neuroactive properties. These microorganisms influence brain function through defined mechanisms, including modulation of neuroinflammation, neurotransmitter production (GABA, serotonin), regulation of the hypothalamic-pituitary-adrenal (HPA) axis, and vagus nerve signaling. Our work critically examines recent advances in applications of psychobiotics for neurological disorders such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and autism spectrum disorder. By integrating evidence from microbiome research, neuroimmunology, and clinical studies, 502
Disciplines :
Sciences du vivant: Multidisciplinaire, généralités & autres
Auteur, co-auteur :
Vijayaram, Srirengaraj; Xiamen Key Laboratory for Feed Quality Testing and Safety Evaluation, Fisheries College, Jimei University, Xiamen, China ; Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Thandalam, India
Mahendran, Karthikeyan; Department of Microbiology, PSG College of Arts and Science, Coimbatore, India
Razafindralambo, Hary ; Université de Liège - ULiège > Département GxABT > Microbial technologies ; Université de Liège - ULiège > Département GxABT > Gestion durable des bio-agresseurs
Ringø, Einar; Norwegian College of Fishery Science, Faculty of Bioscience, Fisheries, and Economics, UiT the Arctic University of Norway, Tromsø, Norway
Kannan, Suruli; Department of Environmental Studies, School of Energy, Environment and Natural Resources, Madurai Kamaraj University, Madurai, India
Sun, Yun-Zhang; Xiamen Key Laboratory for Feed Quality Testing and Safety Evaluation, Fisheries College, Jimei University, Xiamen, China
Langue du document :
Anglais
Titre :
Probiotics, gut microbiota, and brain health: Exploring therapeutic pathways
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