Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)
Eymard, Florent; Louati, Karine; Noël, Ericet al.
2025 • In Knee Surgery, Sports Traumatology, Arthroscopy, 33 (6), p. 2293-2306
[en] Platelet-rich plasma (PRP) could be a vector for certain diseases, and its composition may vary by pathologic condition. The main comorbidities that could affect PRP composition are infectious, oncologic and haematologic. In addition to potential alteration of clinical response, these pathologies could have a significant impact on the local tolerance of PRP as well as a risk of disease dissemination to the injection site. To date, there are few specific recommendations related to these comorbidities to guide clinicians. Therefore, the International Research Group on Platelet Injections (GRIIP) supported a consensus project to develop these recommendations. Methods: Following the 'recommendations by formal consensus' methodology, a steering committee performed a literature review and drafted an initial set of recommendations. They were evaluated by an international rating group (15 specialists in musculoskeletal [MSK] diseases, five haematologists, four
Disciplines :
Orthopedics, rehabilitation & sports medicine Rheumatology
Author, co-author :
Eymard, Florent ; Department of Rheumatology, AP-HP Henri Mondor Hospital, Créteil, Créteil, France
Louati, Karine; Department of Rheumatology, AP-HP Saint Antoine Hospital, Paris, France
Noël, Eric; Ransay Santé, Jean Mermoz Private Hospital, Santy Orthopedic Center, Lyon, France
Abouqal, Redouane; Department of Emergency Medical Services, Ibn Sina Hospital, Rabat, Morocco ; Laboratory of Biostatistics, Department of Public Health, Medical School and Pharmacy, Clinical and Epidemiological Research, University Mohammed V, Rabat, Morocco
Adam, Philippe; Imaging Department, Médipôle Garonne Clinic, Toulouse, France
Allali, Fadoua; Department of Rheumatology, El Ayachi Hospital, Salé, Morocco
Antherieu, Gabriel; Department of Hematology, Lyon University Hospital, Lyon, France
Caers, Jo ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Cognasse, Fabrice; French Blood Establishment Auvergne-Rhône-Alpes, Saint Étienne, France ; INSERM, SAINBIOSE ; Université Jean Monnet, Mines Saint-Étienne, Saint-Etienne, France
Collado, Hervé; Sports Health Medical Institute, Marseille, France
Darrieutort-Laffite, Christelle; Department of Rheumatology, Nantes University Hospital, Nantes, France
Frère, Corinne; Department of Biological Hematology, AP-HP Pitié-Salpêtrière Hospital, Paris, France
Frey, Alain; Department of Sports Medicine, Saint Germain en Laye, Saint Germain Hospital, Poissy, France
Gavillet, Mathilde; Department of Hematology, Lausanne University Hospital, Lausanne, Switzerland
Gremeaux, Vincent; Division of Physical Medicine and Rehabilitation, Swiss Olympic Medical Center, Lausanne University Hospital, Sport Medicine Unit, Lausanne, Switzerland
Heiblig, Mael; Department of Hematology, Lyon University Hospital, Lyon, France
Jerusalem, Guy ; Université de Liège - ULiège > Département des sciences cliniques > Oncologie
Joly, Charlotte; Department of Oncology, AP-HP Henri Mondor Hospital, Créteil, France
Kaux, Jean-François ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Médecine physique, réadaptation et traumatologie du sport
Lamontagne, Martin; Department of Physical and Rehabilitation Medicine, Montreal University Hospital, Montreal, Canada
Leclerc, Mathieu; Department of Clinical Hematology, AP-HP Henri Mondor Hospital, Créteil, France
Léonard, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Maladies infectieuses et médecine interne générale
Lepeule, Raphaël; Department of Microbiology, AP-HP Henri Mondor Hospital, Créteil, France
Lopez-Trabada-Ataz, Daniel; Department of Oncology, AP-HP Saint Antoine Hospital, Paris, France
Magalon, Jérémy; Cell Therapy Laboratory, AP-HM Hôpital De La Conception, Marseille, France
Michel, Fabrice; Department of Physical Medicine and Rehabilitation, Jean-Minjoz University Hospital, Besançon, France
Ornetti, Paul; Department of Rheumatology, Dijon University Hospital, Plateforme d'investigation Technologique CIC-P INSERM 1432, Dijon, France
Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Pons-Tostivint, Elvire; Department of Medical Oncology, Nantes University Hospital, Nantes, France
Real, Fernando; CNRS, Inserm ; Center for Infection and Immunity of Lille, CHU Lille, Institut Pasteur de Lille, L'Université de Lille, Lille, France
Robert, Ghislaine; Medical Office, Redmond, USA
Sanchez, Mikel; Vithas Vitoria Hospital, Arthroscopic Surgery Unit, Vitoria, Spain
Silvestre, Alain; Imaging Department, Osteoarthritis Center, Bordeaux, France
Bard, Hervé; Medical Office Vaudoyer, Paris, France
Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)
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