G protein‐coupled receptors; deorphanization; glia; nervous system; nervous system disorders; neuron; orphan G protein‐coupled receptors; physiology; signalling; Pharmacology
Abstract :
[en] G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important drug targets. This overview emphasises the GPCRs of the nervous system, which are the research focus of the members of ERNEST COST action (CA18133) working group 'Biological roles of signal transduction'. First, the (patho)physiological role of the nervous system GPCRs in the modulation of synapse function is discussed. We then debate the (patho)physiology and pharmacology of opioid, acetylcholine, chemokine, melatonin and adhesion GPCRs in the nervous system. Finally, we address the orphan GPCRs, their implication in the nervous system function and disease, and the challenges that need to be addressed to deorphanize them.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Birgül Iyison, Necla ✱; Department of Molecular Biology and Genetics, University of Bogazici, Istanbul, Turkey
Abboud, Clauda ; Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Abdulrahman, Abdulrasheed O; Institut Cochin, CNRS, INSERM, Université Paris Cité, Paris, France
Bondar, Ana-Nicoleta ; Faculty of Physics, University of Bucharest, Magurele, Romania ; Forschungszentrum Jülich, Institute for Computational Biomedicine (IAS-5/INM-9), Jülich, Germany
Dam, Julie; Institut Cochin, CNRS, INSERM, Université Paris Cité, Paris, France
Georgoussi, Zafiroula ; Laboratory of Cellular Signalling and Molecular Pharmacology, Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Athens, Greece
Giraldo, Jesús ; Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain ; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain ; Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain
Horvat, Anemari ; Laboratory of Neuroendocrinology - Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia ; Laboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia
Karoussiotis, Christos ; Laboratory of Cellular Signalling and Molecular Pharmacology, Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Athens, Greece
Paz-Castro, Alba; Molecular Pharmacology of GPCRs research group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain ; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago, Spain
Scarpa, Miriam; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Schihada, Hannes; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany
Scholz, Nicole; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany
Güvenc Tuna, Bilge; Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkey
Vardjan, Nina ✱; Laboratory of Neuroendocrinology - Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia ; Laboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia
DFG - Deutsche Forschungsgemeinschaft TÜBİTAK - Türkiye Bilimsel ve Teknolojik Araştırma Kurumu CNRS - Centre National de la Recherche Scientifique ANR - Agence Nationale de la Recherche WBI - Wallonie-Bruxelles International European Union. Marie Skłodowska-Curie Actions
Funding text :
This work was supported by the COST action CA18133 (ERNEST). was supported by the Scientific and Technological Research Council of Turkey (T\u00DCB\u0130TAK 119Z921 and 122Z988) and Bogazici University Scientific Research Projects (BAP 14502). and were supported by the grants from the Slovenian Research and Innovation Agency (P3\u20100310, J3\u20102523, J3\u201050104, I0\u20100034, I0\u20100022). was supported by the Institut National de la Sant\u00E9 et de la Recherche M\u00E9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), the \u2018Agence Nationale de la Recherche\u2019 (ANR\u201021\u2010CE14\u20100041, GPCR\u2010Metab ANR\u201023\u2010CE14), the programme \u2018Investissement d'Avenir\u2019 launched by the French Government and implemented by ANR, with the reference \u2018ANR\u201018\u2010IdEx\u20100001\u2019 as part of its programme \u2018Emergence\u2019. was supported by Wallonie\u2010Bruxelles International (WBI.IN) and T\u00E9l\u00E9vie postdoctoral fellowships. was supported by a Marie Sklodowska\u2010Curie (MSCA) postdoctoral fellowship. was supported by the grant PID2020\u2010119136RB\u2010I00 by MCIN/AEI/10.13039/501100011033. acknowledges the support from the programme NutriMED \u2018Nutritional supplements with anti\u2010anxiety and anti\u2010depressant properties from Greek medicinal plants\u2019 (\u039C\u0399S 5185062), which is implemented by the General Secretary of Research and Innovation under the framework of the Action \u2018Research and Innovation Synergies in the Region of Attica\u2019 (\u03A4\u03A4\u03A14\u20100339288), co\u2010financed by Greece and the European Union (NSRF 2014\u20102020). was founded by NutriMED\u2010MIS 5185062. acknowledges support from the Deutsche Forschungsgemeinschaft (265903901, FOR 2149/P01 and CRC 1423 project number 421152132, subproject B06). acknowledges support from the European Union's Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska\u2010Curie grant agreement No 101062195. performed this research under grant number PID2020\u2010119754GB\u2010I00 from the Spanish Ministry of Economy and Competitiveness (MINECO). All figures were created with BioRender.com . We apologise to everybody whose work could not be covered or cited in the paper due to the space limit. NBI NV AH JD DA CA JG ZG \u0391 CK NS HS APC
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