Aubinet, Charlène ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Gillet, Anaïs ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Regnier, Amandine ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Médecine physique, réadaptation et traumatologie du sport ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Language :
English
Title :
Disorders of Consciousness, Language and Communication Following Severe Brain Injury
Alnagger, N., Cardone, P., Martial, C., Laureys, S., Annen, J., & Gosseries, O. (2023). The current and future contribution of neuroimaging to the understanding of disorders of consciousness. La Presse Médicale, 52(2), 104163. https://doi.org/10.1016/j.lpm.2022.104163
Annen, J., Laureys, S., & Gosseries, O. (2020). Brain-computer interfaces for consciousness assessment and communication in severely brain-injured patients. Handbook of Clinical Neurology, 168, 137–152. https://doi.org/10.1016/B978-0-444-63934-9.00011-1
Aubinet, C., Cassol, H., Bodart, O., Sanz, L. R. D., Wannez, S., Martial, C., Thibaut, A., Martens, G., Carrière, M., Gosseries, O., Laureys, S., & Chatelle, C. (2021). Simplified evaluation of CONsciousness disorders (SECONDs) in individuals with severe brain injury: A validation study. Annals of Physical and Rehabilitation Medicine, 64(5), 101432. https://doi.org/10.1016/j.rehab.2020.09.001
Aubinet, C., Cassol, H., Gosseries, O., Bahri, M. A., Larroque, S. K., Majerus, S., Martial, C., Martens, G., Carrière, M., Chatelle, C., Laureys, S., & Thibaut, A. (2020). Brain metabolism but not grey matter volume underlies the presence of language function in the minimally conscious state. Neurorehabilitation and Neural Repair, 34(2), 172–184. https://doi.org/10.1177/1545968319899914
Aubinet, C., Chatelle, C., Gillet, S., Lejeune, N., Thunus, M., Hennen, N., Cassol, H., Laureys, S., & Majerus, S. (2021). The Brief Evaluation of Receptive Aphasia test for the detection of language impairment in patients with severe brain injury. Brain Injury, 35(6), 705–717. https://doi.org/10.1080/02699052.2021.1894482
Aubinet, C., Chatelle, C., Gosseries, O., Carrière, M., Laureys, S., & Majerus, S. (2022). Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review. Neuroscience & Biobehavioral Reviews, 132, 391–409. https://doi.org/10.1016/j.neubiorev.2021.12.001
Aubinet, C., Larroque, S. K., Heine, L., Martial, C., Majerus, S., Laureys, S., & Di Perri, C. (2018). Clinical subcategorization of minimally conscious state according to resting functional connectivity. Human Brain Mapping, 39(11), 4519–4532. https://doi.org/10.1002/hbm.24303
Aubinet, C., Murphy, L., Bahri, M. A., Larroque, S. K., Cassol, H., Annen, J., Carrière, M., Wannez, S., Thibaut, A., Laureys, S., & Gosseries, O. (2018). Brain, Behavior, and Cognitive Interplay in Disorders of Consciousness: A Multiple Case Study. Frontiers in Neurology, 9, 665. https://doi.org/10.3389/fneur.2018.00665
Aubinet, C., Panda, R., Larroque, S. K., Cassol, H., Bahri, M. A., Carrière, M., Wannez, S., Majerus, S., Laureys, S., & Thibaut, A. (2019). Reappearance of Command-Following Is Associated With the Recovery of Language and Internal-Awareness Networks: A Longitudinal Multiple-Case Report. Frontiers in Systems Neuroscience, 13, 8. https://doi.org/10.3389/fnsys.2019.00008
Aubinet, C., Regnier, A., Fritz, P., Pauls, M., Cardone, P., Lejeune, N., Gosseries, O., & Majerus, S. (2024, July). Preliminary data on the validation of the Brief Evaluation of Receptive Aphasia (BERA) tool in post-comatose patients [oral presentation]. 10th Congress of the European Academy of Neurology, Helsinki, Finland.
Aubinet, C., Schnakers, C., & Majerus, S. (2022). Language Assessment in Patients with Disorders of Consciousness. Seminars in Neurology, 42(03), 273–282. https://doi.org/10.1055/s-0042-1755561
Balconi, M., & Arangio, R. (2015). The Relationship Between Coma Near Coma, Disability Ratings, and Event-Related Potentials in Patients with Disorders of Consciousness: A Semantic Association Task. Applied Psychophysiology Biofeedback, 40(4), 327–337. https://doi.org/10.1007/ s10484-015-9304-y
Balconi, M., Arangio, R., & Guarnerio, C. (2013). Disorders of consciousness and N400 ERP measures in response to a semantic task. Journal of Neuropsychiatry and Clinical Neurosciences, 25(3), 237–243. https://doi.org/10.1176/appi.neuropsych.12090227
Baxter, S., Enderby, P., Evans, P., & Judge, S. (2012). Barriers and facilitators to the use of high-technology augmentative and alternative communication devices: A systematic review and qualitative synthesis. International Journal of Language & Communication Disorders, 47(2), 115–129. https://doi.org/10.1111/j.1460-6984.2011.00090.x
Bicciato, G., Narula, G., Brandi, G., Eisele, A., Schulthess, S., Friedl, S., Willms, J. F., Westphal, L., & Keller, E. (2022). Functional NIRS to detect covert consciousness in neurocritical patients. Clinical Neurophysiology, 144, 72–82. https://doi.org/10.1016/j.clinph.2022.10.002
Bodien, Y. G., Vora, I., Barra, A., Chiang, K., Chatelle, C., Goostrey, K., Martens, G., Malone, C., Mello, J., Parlman, K., Ranford, J., Sterling, A., Waters, A. B., Hirschberg, R., Katz, D. I., Mazwi, N., Ni, P., Velmahos, G., Waak, K., Edlow, B. L., … Giacino, J. T. (2023). Feasibility and Validity of the Coma Recovery Scale-Revised for Accelerated Standardized Testing: A Practical Assessment Tool for Detecting Consciousness in the Intensive Care Unit. Annals of neurology, 94(5), 919–924. https://doi.org/10.1002/ana.26740
Bodien, Y., Vora, I., Barra, A., Chiang, K., Chatelle, C., Goostrey, K., Martens, G., Mello, J., Parlman, K., Ranford, J., Sterling, A., Waters, A., Hirschberg, R., Katz, D., Mazwi, N., Ni, P., Velmahos, G., Waak, K., Edlow, B., & Giacino, J. (2024). Feasibility and Validity of the Coma Recovery Scale-Revised For Accelerated Standardized Testing (CRSR-FAST): A Practical Assessment Scale for Detecting Consciousness in the Intensive Care Unit. Archives of Physical Medicine and Rehabilitation, 105(4), e117. https://doi.org/10.1016/j.apmr.2024.02.330
Bodien, Y. G., Allanson, J., Cardone, P., Bonhomme, A., Carmona, J., Chatelle, C., Chennu, S., Conte, M., Dehaene, S., Finoia, P., Heinonen, G., Hersh, J. E., Kamau, E., Lawrence, P. K., Lupson, V. C., Meydan, A., Rohaut, B., Sanders, W. R., Sitt, J. D., … Schiff, N. D. (2024). Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal of Medicine, 391(7), 598–608. https://doi. org/10.1056/NEJMoa2400645
Bodien, Y. G., Threlkeld, Z. D., & Edlow, B. L. (2019). Default mode network dynamics in covert consciousness. Cortex, 119, 571–574. https://doi.org/10.1016/j.cortex.2019.01.014
Braiman, C., Fridman, E. A., Conte, M. M., Voss, H. U., Reichenbach, C. S., Reichenbach, T., & Schiff, N. D. (2018). Cortical Response to the Natural Speech Envelope Correlates with Neuroimaging Evidence of Cognition in Severe Brain Injury. Current Biology, 28(23), 3833–3839.e3. https://doi.org/10.1016/j.cub.2018.10.057
Bruno, M.-A., Majerus, S., Boly, M., Vanhaudenhuyse, A., Schnakers, C., Gosseries, O., Boveroux, P., Kirsch, M., Demertzi, A., Bernard, C., Hustinx, R., Moonen, G., & Laureys, S. (2012). Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients. Journal of Neurology, 259(6), 1087–1098. https://doi.org/10.1007/s00415-011-6303-7
Bruno, M.-A., Vanhaudenhuyse, A., Thibaut, A., Moonen, G., & Laureys, S. (2011). From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: Recent advances in our understanding of disorders of consciousness. Journal of Neurology, 258(7), 1373–1384. https://doi.org/10.1007/s00415-011-6114-x
Cardone, P., Bonhomme, A., Bonhomme, V., Lejeune, N., Staquet, C., Defresne, A., Alnagger, N., Ezan, P., Lee, M., Piarulli, A., Van Goethem, S., Montupil, J., Thibaut, A., Martial, C., & Gosseries, O. (2025). A pilot human study using ketamine to treat disorders of consciousness. iScience, 28(1), 111639. https://doi.org/10.1016/j.isci.2024.111639
Chapman, R. M., & Bragdon, H. R. (1964). Evoked Responses to Numerical and Non-Numerical Visual Stimuli while Problem Solving | Nature. Nature, 203, 1155–1157. https://doi.org/10.1038/2031155a0
Chatelle, C., De Val, M.-D., Catano, A., Chaskis, C., Seeldrayers, P., Laureys, S., Biston, P., & Schnakers, C. (2016). Is the Nociception Coma Scale-Revised a Useful Clinical Tool for Managing Pain in Patients With Disorders of Consciousness? The Clinical Journal of Pain, 32(4), 321–326. https://doi.org/10.1097/AJP.0000000000000259
Cherkasova, A. N., Yatsko, K. A., Kovyazina, M. S., Varako, N. A., Kremneva, E. I., Ryabinkina, Yu. V., Suponeva, N. A., & Piradov, M. A. (2023). Detection of the “Covert Cognition” Phenomenon in Patients with Chronic Disorders of Consciousness: A Review of fMRI Data with Paradigms. Neuroscience and Behavioral Physiology, 53(8), 1397–1409. https://doi.org/10.1007/s11055-023-01533-2
Chudy, D., Deletis, V., Paradžik, V., Dubroja, I., Marčinković, P., Orešković, D., Chudy, H., & Raguž, M. (2023). Deep brain stimulation in disorders of consciousness: 10 years of a single center experience. Scientific Reports, 13(1), 19491. https://doi.org/10.1038/s41598-023-46300-y
Claassen, J., Doyle, K., Matory, A., Couch, C., Burger, K. M., Velazquez, A., Okonkwo, J. U., King, J.-R., Park, S., Agarwal, S., Roh, D., Megjhani, M., Eliseyev, A., Connolly, E. S., & Rohaut, B. (2019). Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury. New England Journal of Medicine, 380(26), 2497–2505. https://doi.org/10.1056/NEJMoa1812757
Claassen, J., Kondziella, D., Alkhachroum, A., Diringer, M., Edlow, B. L., Fins, J. J., Gosseries, O., Hannawi, Y., Rohaut, B., Schnakers, C., Stevens, R. D., Thibaut, A., Monti, M., & the Curing Coma Campaign, and Its Contributing Collaborators. (2023). Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care. https://doi.org/10.1007/s12028-023-01769-3
Coleman, M. R., Davis, M. H., Rodd, J. M., Robson, T., Ali, A., Owen, A. M., & Pickard, J. D. (2009). Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain, 132(9), 2541–2552. https://doi.org/10.1093/brain/awp183
Coleman, M. R., Rodd, J. M., Davis, M. H., Johnsrude, I. S., Menon, D. K., Pickard, J. D., & Owen, A. M. (2007). Do vegetative patients retain aspects of language comprehension? Evidence from fMRI. Brain, 130(10), 2494–2507. https://doi.org/10.1093/brain/awm170
De Bellis, F., Magliacano, A., Fasano, C., Spinola, M., Campana, B., & Estraneo, A. (2022). Development of an Italian version of the functional communication measures and preliminary observations in patients with severe acquired brain injury and emerging from a prolonged disorder of consciousness. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 43(9), 5267–5273. https://doi.org/10.1007/s10072-022-06173-x
Demertzi, A., Antonopoulos, G., Heine, L., Voss, H. U., Crone, J. S., De Los Angeles, C., Bahri, M. A., Di Perri, C., Vanhaudenhuyse, A., Charland-Verville, V., Kronbichler, M., Trinka, E., Phillips, C., Gomez, F., Tshibanda, L., Soddu, A., Schiff, N. D., Whitfield-Gabrieli, S., & Laureys, S. (2015). Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients. Brain, 138(9), 2619–2631. https://doi.org/10.1093/brain/awv169
Demertzi, A., Ledoux, D., Bruno, M.-A., Vanhaudenhuyse, A., Gosseries, O., Soddu, A., Schnakers, C., Moonen, G., & Laureys, S. (2011). Attitudes towards end-of-life issues in disorders of consciousness: A European survey. Journal of Neurology, 258(6), 1058–1065. https://doi.org/10.1007/ s00415-010-5882-z
Dijkstra, K. V., Farquhar, J. D. R., & Desain, P. W. M. (2020). The N400 for brain computer interfacing: Complexities and opportunities. Journal of Neural Engineering, 17(2), 022001. https://doi.org/10.1088/1741-2552/ab702e
Diserens, K., Meyer, I. A., Jöhr, J., Pincherle, A., Dunet, V., Pozeg, P., Ryvlin, P., Mureşanu, D. F., Stevens, R. D., & Schiff, N. D. (2023). A Focus on Subtle Signs and Motor Behavior to Unveil Awareness in Unresponsive Brain-Impaired Patients: The Importance of Being Clinical. Neurology, 100(24), 1144–1150. https://doi.org/10.1212/ WNL.0000000000207067
Dong, X., Tang, Y., Zhou, Y., & Feng, Z. (2023). Stimulation of vagus nerve for patients with disorders of consciousness: A systematic review. Frontiers in Neuroscience, 17. https://doi.org/10.3389/fnins.2023.1257378
Duszyk-Bogorodzka, A., Zieleniewska, M., & Jankowiak-Siuda, K. (2022). Brain Activity Characteristics of Patients With Disorders of Consciousness in the EEG Resting State Paradigm: A Review. Frontiers in Systems Neuroscience, 16. https://doi.org/10.3389/fnsys.2022.654541
Edlow, B. L., Chatelle, C., Spencer, C. A., Chu, C. J., Bodien, Y. G., O’Connor, K. L., Hirschberg, R. E., Hochberg, L. R., Giacino, J. T., Rosenthal, E. S., & Wu, O. (2017). Early detection of consciousness in patients with acute severe traumatic brain injury. Brain, 140(9), 2399–2414. https://doi.org/10.1093/brain/awx176
Edlow, B. L., Claassen, J., Schiff, N. D., & Greer, D. M. (2021). Recovery from disorders of consciousness: Mechanisms, prognosis and emerging therapies. Nature Reviews Neurology, 17(3), 135–156. https://doi.org/10.1038/ s41582-020-00428-x
Edlow, B. L., & Menon, D. K. (2024). Covert Consciousness in the ICU. Critical Care Medicine, 52(9), 1414–1426. https://doi.org/10.1097/CCM.0000000000006372
Estraneo, A., Fiorenza, S., Magliacano, A., Formisano, R., Mattia, D., Grippo, A., Romoli, A. M., Angelakis, E., Cassol, H., Thibaut, A., Gosseries, O., Lamberti, G., Noé, E., Bagnato, S., Edlow, B. L., Chatelle, C., Lejeune, N., Veeramuthu, V., Bartolo, M., … Aabid, H. (2020). Multicenter prospective study on predictors of short-term outcome in disorders of consciousness. Neurology, 95(11). https://doi.org/10.1212/WNL.0000000000010254
Ferraro, S., Nigri, A., D’Incerti, L., Rosazza, C., Sattin, D., Rossi Sebastiano, D., Visani, E., Duran, D., Marotta, G., Demichelis, G., Catricala’, E., Kotz, S., Verga, L., Leonardi, M., Cappa, S., & Bruzzone, M. G. (2020). Preservation of Language Processing and Auditory Performance in Patients With Disorders of Consciousness: A Multimodal Assessment. Frontiers in Neurology, 11, 526465. https://doi.org/10.3389/fneur.2020.526465
Formica, C., De Cola, M. C., Corallo, F., & Lo Buono, V. (2024). Role of Alternative and Augmentative Communication in Three Cases of Severe Acquired Brain Injury: A Neurorehabilitative Approach. Brain Sciences, 14(7), 709. https://doi.org/10.3390/brainsci14070709
Formisano, R., Toppi, J., Risetti, M., Aloisi, M., Contrada, M., Ciurli, P. M., Falletta Caravasso, C., Luccichenti, G., Astolfi, L., Cincotti, F., & Mattia, D. (2019). Language-Related Brain Potentials in Patients With Disorders of Consciousness: A Follow-up Study to Detect “Covert” Language Disorders. Neurorehabilitation and Neural Repair, 33(7), 513–522. https://doi.org/10.1177/1545968319846123
Fried-Oken, M., Mooney, A., & Peters, B. (2015). Supporting communication for patients with neurodegenerative disease. NeuroRehabilitation, 37(1), 69–87. https://doi.org/10.3233/NRE-151241
Galiotta, V., Quattrociocchi, I., D’Ippolito, M., Schettini, F., Aricò, P., Sdoia, S., Formisano, R., Cincotti, F., Mattia, D., & Riccio, A. (2022). EEG-based Brain-Computer Interfaces for people with Disorders of Consciousness: Features and applications. A systematic review. Frontiers in Human Neuroscience, 16, 1040816. https://doi.org/10.3389/fnhum.2022.1040816
Giacino J. T. (1996). Sensory stimulation: theoretical perspectives and the evidence for effectiveness. NeuroRehabilitation, 6(1), 69–78. https://doi.org/10.3233/ NRE-1996-6108
Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., Kelly, J. P., Rosenberg, J. H., Whyte, J., Zafonte, R. D., & Zasler, N. D. (2002). The minimally conscious state: Definition and diagnostic criteria. Neurology, 58(3), 349–353. https://doi.org/10.1212/WNL.58.3.349
Giacino, J. T., Kalmar, K., & Whyte, J. (2004). The JFK Coma Recovery Scale-Revised: Measurement characteristics and diagnostic utility11 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated. Archives of Physical Medicine and Rehabilitation, 85(12), 2020–2029. https://doi.org/10.1016/j.apmr.2004.02.033
Giacino, J. T., Katz, D. I., Schiff, N. D., Whyte, J., Ashman, E. J., Ashwal, S., Barbano, R., Hammond, F. M., Laureys, S., Ling, G. S. F., Nakase-Richardson, R., Seel, R. T., Yablon, S., Getchius, T. S. D., Gronseth, G. S., & Armstrong, M. J. (2018). Practice guideline update recommendations summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research. Neurology, 91(10), 450–460. https://doi.org/10.1212/WNL.0000000000005926
Giacino, J. T., Sherer, M., Christoforou, A., Maurer-Karattup, P., Hammond, F. M., Long, D., & Bagiella, E. (2020). Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury. Journal of Neurotrauma, 37(2), 357–365. https://doi.org/10.1089/neu.2019.6429
Gosseries, O., Zasler, N. D., & Laureys, S. (2014). Recent advances in disorders of consciousness: Focus on the diagnosis. Brain Injury, 28(9), 1141–1150. https://doi.org/10.3109/02699052.2014.920522
Guger, C., Spataro, R., Pellas, F., Allison, B. Z., Heilinger, A., Ortner, R., Cho, W., Xu, R., La Bella, V., Edlinger, G., Annen, J., Mandalá, G., Chatelle, C., & Laureys, S. (2018). Assessing Command-Following and Communication With Vibro-Tactile P300 Brain-Computer Interface Tools in Patients With Unresponsive Wakefulness Syndrome. Frontiers in Neuroscience, 12, 423. https://doi.org/10.3389/ fnins.2018.00423
Gui, P., Jiang, Y., Zang, D., Qi, Z., Tan, J., Tanigawa, H., Jiang, J., Wen, Y., Xu, L., Zhao, J., Mao, Y., Poo, M., Ding, N., Dehaene, S., Wu, X., & Wang, L. (2020). Assessing the depth of language processing in patients with disorders of consciousness. Nature Neuroscience, 23(6), 761–770. https://doi.org/10.1038/s41593-020-0639-1
Hampshire, A., Parkin, B. L., Cusack, R., Espejo, D. F., Allanson, J., Kamau, E., Pickard, J. D., & Owen, A. M. (2013). Assessing residual reasoning ability in overtly non-communicative patients using fMRI. NeuroImage: Clinical, 2, 174–183. https://doi.org/10.1016/j.nicl.2012.11.008
Heine, L., Castro, M., Martial, C., Tillmann, B., Laureys, S., & Perrin, F. (2015). Exploration of Functional Connectivity During Preferred Music Stimulation in Patients with Disorders of Consciousness. Frontiers in Psychology, 6, 1704. https://doi.org/10.3389/fpsyg.2015.01704
Herbert, C. (2024). Brain-computer interfaces and human factors: The role of language and cultural differences—Still a missing gap? Frontiers in Human Neuroscience, 18, 1305445. https://doi.org/10.3389/fnhum.2024.1305445
Huang, J., Qiu, L., Lin, Q., Xiao, J., Huang, Y., Huang, H., Zhou, X., Shi, X., Wang, F., He, Y., & Pan, J. (2021). Hybrid asynchronous brain–computer interface for yes/no communication in patients with disorders of consciousness. Journal of Neural Engineering, 18(5), 056001. https://doi.org/10.1088/1741-2552/abf00c
Jacobson, S. D., Kansara, V., Assuras, S., Shen, Q., Kruger, L., Carmona, J., Song, Y. L., Cespedes, L., Yazdi, M., Velazquez, A., Gonzales, I., Egawa, S., Connolly, E. S., Ghoshal, S., Roh, D., Agarwal, S., Park, S., & Claassen, J. (2024). Impact of Aphasia on Brain Activation to Motor Commands in Patients with Acute Intracerebral Hemorrhage. Neurocritical Care. https://doi.org/10.1007/ s12028-024-02086-z
Kazazian, K., Abdalmalak, A., Novi, S. L., Norton, L., Moulavi-Ardakani, R., Kolisnyk, M., Gofton, T. E., Mesquita, R. C., Owen, A. M., & Debicki, D. B. (2024). Functional near-infrared spectroscopy: A novel tool for detecting consciousness after acute severe brain injury. Proceedings of the National Academy of Sciences of the United States of America, 121(36), e2402723121. https://doi.org/10.1073/pnas.2402723121
Klein, F., Kohl, S. H., Lührs, M., Mehler, D. M. A., & Sorger, B. (2024). From lab to life: Challenges and perspectives of fNIRS for haemodynamic-based neurofeedback in real-world environments. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 379(1915), 20230087. https://doi.org/10.1098/rstb.2023.0087
Kondziella, D., Bender, A., Diserens, K., van Erp, W., Estraneo, A., Formisano, R., Laureys, S., Naccache, L., Ozturk, S., Rohaut, B., Sitt, J. D., Stender, J., Tiainen, M., Rossetti, A. O., Gosseries, O., Chatelle, C., & EAN Panel on Coma, Disorders of Consciousness. (2020). European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness. European Journal of Neurology, 27(5), 741–756. https://doi.org/10.1111/ene.14151
Kondziella, D., Friberg, C. K., Frokjaer, V. G., Fabricius, M., & Møller, K. (2016). Preserved consciousness in vegetative and minimal conscious states: Systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 87(5), 485–492. https://doi.org/10.1136/jnnp-2015-310958
Kotchoubey, B., Veser, S., Real, R., Herbert, C., Lang, S., & Kubler, A. (2013). Towards a more precise neurophysiological assessment of cognitive functions in patients with disorders of consciousness. Restorative Neurology and Neuroscience, 31(4), 473–485. https://doi.org/10.3233/RNN-120307
Kotchoubey, B., Yu, T., Mueller, F., Vogel, D., Veser, S., & Lang, S. (2013). True or false? Activations of language-related areas in patients with disorders of consciousness. Current Pharmaceutical Design, 999(999), 27–28. https://doi.org/10.2174/13816128113196660645
Laforge, G., Gonzalez-Lara, L. E., Owen, A. M., & Stojanoski, B. (2020). Individualized assessment of residual cognition in patients with disorders of consciousness. NeuroImage: Clinical, 28, 102472. https://doi.org/10.1016/j.nicl.2020.102472
Laureys, S., Perrin, F., Faymonville, M.-E., Schnakers, C., Boly, M., Bartsch, V., & Maquet, P. (2004). Cerebral processing in the minimally conscious state. Neurology, 63(5), 916–918. https://doi.org/10.1212/01.WNL.0000137421.30792.9B
Li, J., Huang, B., Wang, F., Xie, Q., Xu, C., Huang, H., & Pan, J. (2022). A Potential Prognosis Indicator Based on P300 Brain–Computer Interface for Patients with Disorder of Consciousness. Brain Sciences, 12(11), 1556. https://doi.org/10.3390/brainsci12111556
Li, M., Yang, Y., Zhang, Y., Gao, Y., Jing, R., Dang, Y., Chen, X., He, J., & Si, J. (2021). Detecting Residual Awareness in Patients With Prolonged Disorders of Consciousness: An fNIRS Study. Frontiers in Neurology, 12, 618055. https://doi.org/10.3389/fneur.2021.618055
Li, X., Li, C., Hu, N., & Wang, T. (2020). Music Interventions for Disorders of Consciousness: A Systematic Review and Meta-analysis. The Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses, 52(4), 146–151. https://doi.org/10.1097/JNN.0000000000000511
Llorens, R., Ippoliti, C., Navarro, M. D., Colomer, C., Maza, A., Goizueta, S., Olaya, J., Moliner, B., Ferri, J., & Noé, E. (2024). Minimally conscious state plus versus minus: Likelihood of emergence and long‐term functional independence. Annals of Clinical and Translational Neurology, 11(3), 719–728. https://doi.org/10.1002/acn3.51993
Mackey, J., McCulloch, H., Scheiner, G., Barker, A., & Callaway, L. (2023). Speech pathologists’ perspectives on the use of augmentative and alternative communication devices with people with acquired brain injury and reflections from lived experience. Brain Impairment, 24(2), 168–184. https://doi.org/10.1017/BrImp.2023.9
Majerus, S., Bruno, M.-A., Schnakers, C., Giacino, J. T., & Laureys, S. (2009). The problem of aphasia in the assessment of consciousness in brain-damaged patients. In Progress in Brain Research (Vol. 177, p. 49–61). Elsevier. https://doi.org/10.1016/S0079-6123(09)17705-1
Majerus, S., De Linden, M. V., & Shiel, A. (2000). Wessex Head Injury Matrix and Glasgow/Glasgow-Liege Coma Scale: A Validation and Comparison Study. Neuropsychological Rehabilitation, 10(2), 167–184. https://doi.org/10.1080/096020100389237
Martial, C., Cassol, H., Laureys, S., & Gosseries, O. (2020). Near-Death Experience as a Probe to Explore (Disconnected) Consciousness. Trends in Cognitive Sciences, 24(3), 173–183. https://doi.org/10.1016/j.tics.2019.12.010
Monti, M. M., Vanhaudenhuyse, A., Coleman, M. R., Boly, M., Pickard, J. D., Tshibanda, L., Owen, A. M., & Laureys, S. (2010). Willful modulation of brain activity in disorders of consciousness. The New England Journal of Medicine, 362(7), 579–589. https://doi.org/10.1056/ NEJMoa0905370
Murtaugh, B., Fager, S., & Sorenson, T. (2024). Emergence from Disorders of Consciousness. Physical Medicine and Rehabilitation Clinics of North America, 35(1), 175–191. https://doi.org/10.1016/j.pmr.2023.07.002
Naci, L., Haugg, A., MacDonald, A., Anello, M., Houldin, E., Naqshbandi, S., & Owen, A. M. (2018). Functional diversity of brain networks supports consciousness and verbal intelligence. Scientific Reports, 8(1), 1–15. https://doi.org/10.1038/s41598-018-31525-z
Nagels-Coune, L., Riecke, L., Benitez-Andonegui, A., Klinkhammer, S., Goebel, R., De Weerd, P., Lührs, M., & Sorger, B. (2021). See, Hear, or Feel – to Speak: A Versatile Multiple-Choice Functional Near-Infrared Spectroscopy-Brain-Computer Interface Feasible With Visual, Auditory, or Tactile Instructions. Frontiers in Human Neuroscience, 15, 784522. https://doi.org/10.3389/fnhum.2021.784522
Nakase-Richardson, R., Yablon, S. A., Sherer, M., Nick, T. G., & Evans, C. C. (2009). Emergence from minimally conscious state: Insights from evaluation of posttraumatic confusion. Neurology, 73(14), 1120–1126. https://doi.org/10.1212/WNL.0b013e3181bacf34
Nigri, A., Catricalà, E., Ferraro, S., Bruzzone, M. G., D’Incerti, L., Sattin, D., Sebastiano, D. R., Franceschetti, S., Marotta, G., Benti, R., Leonardi, M., Cappa, S. F., & CRC - Coma Research Centre members. (2017). The neural correlates of lexical processing in disorders of consciousness. Brain imaging and behavior, 11(5), 1526–1537. https://doi.org/10.1007/s11682-016-9613-7
Ortner, R., Aloise, F., Prückl, R., Schettini, F., Putz, V., Scharinger, J., Opisso, E., Costa, U., & Guger, C. (2011). Accuracy of a P300 speller for people with motor impairments: A comparison. Clinical EEG and Neuroscience, 42(4), 214–218. https://doi.org/10.1177/155005941104200405
Owen, A. M., Coleman, M. R., Boly, M., Davis, M. H., Laureys, S., & Pickard, J. D. (2006). Detecting Awareness in the Vegetative State. Science, 313(5792), 1402. https://doi.org/10.1126/science.1130197
Pape, T. L.-B., Rosenow, J. M., Steiner, M., Parrish, T., Guernon, A., Harton, B., Patil, V., Bhaumik, D. K., McNamee, S., Walker, M., Froehlich, K., Burress, C., Odle, C., Wang, X., Herrold, A. A., Zhao, W., Reda, D., Mallinson, T., Conneely, M., & Nemeth, A. J. (2015). Placebo-Controlled Trial of Familiar Auditory Sensory Training for Acute Severe Traumatic Brain Injury: A Preliminary Report. Neurorehabilitation and Neural Repair, 29(6), 537–547. https://doi.org/10.1177/1545968314554626
Pfurtscheller, G. (2010). The hybrid BCI. Frontiers in Neuroscience. https://doi.org/10.3389/fnpro.2010.00003
Porcaro, C., Nemirovsky, I. E., Riganello, F., Mansour, Z., Cerasa, A., Tonin, P., Stojanoski, B., & Soddu, A. (2022). Diagnostic Developments in Differentiating Unresponsive Wakefulness Syndrome and the Minimally Conscious State. Frontiers in Neurology, 12, 778951. https://doi.org/10.3389/fneur.2021.778951
Pundole, A., & Crawford, S. (2018). The assessment of language and the emergence from disorders of consciousness. Neuropsychological Rehabilitation, 28(8), 1285–1294. https://doi.org/10.1080/09602011.2017.1307766
Pundole, A., Varley, R., & Beeke, S. (2021). Assessing emergence from a prolonged disorder of consciousness: Current opinion and practice in the UK. Neuropsychological Rehabilitation, 31(7), 1003–1027. https://doi.org/10.1080/09602011.2020.1758160
Rodriguez Moreno, D., Schiff, N. D., Giacino, J., Kalmar, K., & Hirsch, J. (2010). A network approach to assessing cognition in disorders of consciousness. Neurology, 75(21), 1871–1878. https://doi.org/10.1212/WNL.0b013e3181feb259
Saha, S., Mamun, K. A., Ahmed, K., Mostafa, R., Naik, G. R., Darvishi, S., Khandoker, A. H., & Baumert, M. (2021). Progress in Brain Computer Interface: Challenges and Opportunities. Frontiers in Systems Neuroscience, 15, 578875. https://doi.org/10.3389/fnsys.2021.578875
Sanz, L. R. D., Aubinet, C., Cassol, H., Bodart, O., Wannez, S., Bonin, E. A. C., Barra, A., Lejeune, N., Martial, C., Chatelle, C., Ledoux, D., Laureys, S., Thibaut, A., & Gosseries, O. (2021). SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients. Journal of Visualized Experiments: JoVE, 168. https://doi.org/10.3791/61968-v
Sanz, L. R. D., Laureys, S., & Gosseries, O. (2018). Disorders of consciousness: Behavioral and neuroimaging studies. Revue de Neuropsychologie, 10(4), 313–321. https://doi.org/10.1684/nrp.2018.0481
Sanz, L. R. D., Lejeune, N., Szymkowicz, E., Bonin, E. A. C., Panda, R., Sala, A., Thibaut, A., Huerta-Gutierrez, R., Dardenne, N., Dikenstein, D., Van Goethem, S., Ledoux, D., Hustinx, R., Stender, J., Farber, N. M., Zafonte, R. D., Schiff, N. D., Laureys, S., & Gosseries, O. (2024). Apomorphine for prolonged disorders of consciousness: A multimodal open-label study. EClinicalMedicine, 78, 102925. https://doi.org/10.1016/j.eclinm.2024.102925
Schiff, N. D. (2015). Cognitive Motor Dissociation Following Severe Brain Injuries. JAMA Neurology, 72(12), 1413. https://doi.org/10.1001/jamaneurol.2015.2899
Schiff, N. D., Diringer, M., Diserens, K., Edlow, B. L., Gosseries, O., Hill, N. J., Hochberg, L. R., Ismail, F. Y., Meyer, I. A., Mikell, C. B., Mofakham, S., Molteni, E., Polizzotto, L., Shah, S. A., Stevens, R. D., Thengone, D., & and the Curing Coma Campaign and its Contributing Members. (2024). Brain–Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap. Neurocritical Care, 41(1), 129–145. https://doi.org/10.1007/s12028-023-01924-w
Schiff, N. D., Rodriguez-Moreno, D., Kamal, A., Kim, K. H. S., Giacino, J. T., Plum, F., & Hirsch, J. (2005). fMRI reveals large-scale network activation in minimally conscious patients. Neurology, 64(3), 514–523. https://doi.org/10.1212/01.WNL.0000150883.10285.44
Schnakers, C., Bessou, H., Rubi-Fessen, I., Hartmann, A., Fink, G. R., Meister, I., Giacino, J. T., Laureys, S., & Majerus, S. (2015). Impact of Aphasia on Consciousness Assessment: A Cross-Sectional Study. Neurorehabilitation and Neural Repair, 29(1), 41–47. https://doi.org/10.1177/1545968314528067
Schnakers, C., Hirsch, M., Noé, E., Llorens, R., Lejeune, N., Veeramuthu, V., De Marco, S., Demertzi, A., Duclos, C., Morrissey, A.-M., Chatelle, C., & Estraneo, A. (2020). Covert Cognition in Disorders of Consciousness: A Meta-Analysis. Brain Sciences, 10(12), 930. https://doi.org/10.3390/brainsci10120930
Schnakers, C., Magee, W. L., & Harris, B. (2016). Sensory Stimulation and Music Therapy Programs for Treating Disorders of Consciousness. Frontiers in Psychology, 7. https://doi.org/10.3389/fpsyg.2016.00297
Schnakers, C., & Majerus, S. (2011). Évaluation comportementale et diagnostic des états de conscience altérée. In Coma et états de conscience altérée (p. 3–16). Springer. https://doi.org/10.1007/978-2-8178-0127-8_2
Schnakers, C., Vanhaudenhuyse, A., Giacino, J., Ventura, M., Boly, M., Majerus, S., Moonen, G., & Laureys, S. (2009). Diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment. BMC Neurology, 9, 35. https://doi.org/10.1186/1471-2377-9-35
Seel, R. T., Douglas, J., Dennison, A. C., Heaner, S., Farris, K., & Rogers, C. (2013). Specialized early treatment for persons with disorders of consciousness: Program components and outcomes. Archives of Physical Medicine and Rehabilitation, 94(10), 1908–1923. https://doi.org/10.1016/j.apmr.2012.11.052
Seel, R. T., Sherer, M., Whyte, J., Katz, D. I., Giacino, J. T., Rosenbaum, A. M., & Zasler, N. (2010). Assessment scales for disorders of consciousness: Evidence-based recommendations for clinical practice and research. Archives of Physical Medicine and Rehabilitation, 91(12), 1795–1813. https://doi.org/10.1016/j.apmr.2010.07.218
Shiel, A., Horn, S. A., Wilson, B. A., Watson, M. J., Campbell, M. J., & Mclellan, D. L. (2000). The Wessex Head Injury Matrix (WHIM) main scale: A preliminary report on a scale to assess and monitor patient recovery after severe head injury. Clinical Rehabilitation, 14(4), 408–416. https://doi.org/10.1191/0269215500cr326oa
Sokoliuk, R., Degano, G., Banellis, L., Melloni, L., Hayton, T., Sturman, S., Veenith, T., Yakoub, K. M., Belli, A., Noppeney, U., & Cruse, D. (2020). Covert speech comprehension predicts recovery from acute unresponsive states. Annals of Neurology. https://doi.org/10.1002/ana.25995
Spataro, R., Xu, Y., Xu, R., Mandalà, G., Allison, B. Z., Ortner, R., Heilinger, A., La Bella, V., & Guger, C. (2022). How brain-computer interface technology may improve the diagnosis of the disorders of consciousness: A comparative study. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.959339
Sreedharan, S., Chandran, A., Yanamala, V. R., Sylaja, P. N., Kesavadas, C., & Sitaram, R. (2020). Self-regulation of language areas using real-time functional MRI in stroke patients with expressive aphasia. Brain Imaging and Behavior, 14(5), 1714–1730. https://doi.org/10.1007/ s11682-019-00106-7
Stender, J., Gosseries, O., Bruno, M.-A., Charland-Verville, V., Vanhaudenhuyse, A., Demertzi, A., Chatelle, C., Thonnard, M., Thibaut, A., Heine, L., Soddu, A., Boly, M., Schnakers, C., Gjedde, A., & Laureys, S. (2014). Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: A clinical validation study. The Lancet, 384(9942), 514–522. https://doi.org/10.1016/S0140-6736(14)60042-8
Teasdale, G., & Jennett, B. (1974). ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS. The Lancet, 304(7872), 81–84. https://doi.org/10.1016/S0140-6736 (74)91639-0
Thibaut, A., Bodien, Y. G., Laureys, S., & Giacino, J. T. (2019). Minimally conscious state “plus”: Diagnostic criteria and relation to functional recovery. Journal of Neurology. https://doi.org/10.1007/s00415-019-09628-y
Thibaut, A., Bodien, Y. G., Laureys, S., & Giacino, J. T. (2020). Minimally conscious state “plus”: Diagnostic criteria and relation to functional recovery. Journal of Neurology, 267(5), 1245–1254. https://doi.org/10.1007/s00415-019-09628-y
Thibaut, A., Bruno, M.-A., Ledoux, D., Demertzi, A., & Laureys, S. (2014). tDCS in patients with disorders of consciousness: Sham-controlled randomized double-blind study. Neurology, 82(13), 1112–1118. https://doi.org/10.1212/WNL.0000000000000260
Thibaut, A., Fregni, F., Estraneo, A., Fiorenza, S., Noe, E., Llorens, R., Ferri, J., Formisano, R., Morone, G., Bender, A., Rosenfelder, M., Lamberti, G., Kodratyeva, E., Kondratyev, S., Legostaeva, L., Suponeva, N., Krewer, C., Müller, F., Dardenne, N., … IBIA DOC-SIG. (2023). Sham-controlled randomized multicentre trial of transcranial direct current stimulation for prolonged disorders of consciousness. European Journal of Neurology, 30(10), 3016–3031. https://doi.org/10.1111/ene.15974
Thibaut, A., Panda, R., Annen, J., Sanz, L. R. D., Naccache, L., Martial, C., Chatelle, C., Aubinet, C., Bonin, E. A. C., Barra, A., Briand, M., Cecconi, B., Wannez, S., Stender, J., Laureys, S., & Gosseries, O. (2021). Preservation of Brain Activity in Unresponsive Patients Identifies MCS Star. Annals of Neurology, 90(1), 89–100. https://doi.org/10.1002/ana.26095
Thibaut, A., Schiff, N., Giacino, J., Laureys, S., & Gosseries, O. (2019). Therapeutic interventions in patients with prolonged disorders of consciousness. The Lancet Neurology, 18(6), 600–614. https://doi.org/10.1016/S1474-4422(19)30031-6
Threlkeld, Z. D., Bodien, Y. G., Rosenthal, E. S., Giacino, J. T., Nieto-Castanon, A., Wu, O., Whitfield-Gabrieli, S., & Edlow, B. L. (2018). Functional networks reemerge during recovery of consciousness after acute severe traumatic brain injury. Cortex, 106, 299–308. https://doi.org/10.1016/j.cortex.2018.05.004
Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., Phillips, C., Soddu, A., Luxen, A., Moonen, G., & Laureys, S. (2011). Two Distinct Neuronal Networks Mediate the Awareness of Environment and of Self. Journal of Cognitive Neuroscience, 23(3), 570–578. https://doi.org/10.1162/jocn.2010.21488
Vatrano, M., Nemirovsky, I. E., Tonin, P., & Riganello, F. (2023). Assessing Consciousness through Neurofeedback and Neuromodulation: Possibilities and Challenges. Life (Basel, Switzerland), 13(8), 1675. https://doi.org/10.3390/ life13081675
Vitello, M. M., Briand, M.-M., Ledoux, D., Annen, J., El Tahry, R., Laureys, S., Martin, D., Gosseries, O., & Thibaut, A. (2023). Transcutaneous vagal nerve stimulation to treat disorders of consciousness: Protocol for a double-blind randomized controlled trial. International Journal of Clinical and Health Psychology, 23(2), 100360. https://doi.org/10.1016/j.ijchp.2022.100360
Vitello, M. M., Rosenfelder, M. J., Cardone, P., Niimi, M., Willacker, L., Thibaut, A., Lejeune, N., Laureys, S., Bender, A., & Gosseries, O. (2023). A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness. Frontiers in Neurology, 14. https://doi.org/10.3389/fneur.2023.1216468
Wang, F., He, Y., Qu, J., Xie, Q., Lin, Q., Ni, X., Chen, Y., Pan, J., Laureys, S., Yu, R., & Li, Y. (2017). Enhancing clinical communication assessments using an audiovisual BCI for patients with disorders of consciousness. Journal of Neural Engineering, 14(4), 046024. https://doi.org/10.1088/17412552/aa6c31
Wannez, S., Heine, L., Thonnard, M., Gosseries, O., Laureys, S., & Coma Science Group collaborators. (2017). The repetition of behavioral assessments in diagnosis of disorders of consciousness. Annals of Neurology, 81(6), 883–889. https://doi.org/10.1002/ana.24962
Wolpaw, J. R., Millán, J. D. R., & Ramsey, N. F. (2020). Brain-computer interfaces: Definitions and principles. In Handbook of Clinical Neurology (Vol. 168, p. 15–23). Elsevier. https://doi.org/10.1016/B978-0-444-63934-9.00002-0
Yi, Z., Pan, J., Chen, Z., Lu, D., Cai, H., Li, J., & Xie, Q. (2024). A Hybrid BCI Integrating EEG and Eye-Tracking for Assisting Clinical Communication in Patients With Disorders of Consciousness. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 32, 2759–2771. https://doi.org/10.1109/TNSRE.2024.3435016
Young, M. J., Edlow, B. L., & Bodien, Y. G. (2024). Covert consciousness. NeuroRehabilitation, 54(1), 23–42. https://doi.org/10.3233/NRE-230123
Young, M. J., Fecchio, M., Bodien, Y. G., & Edlow, B. L. (2024). Covert cortical processing: A diagnosis in search of a definition. Neuroscience of Consciousness, 2024(1), niad026. https://doi.org/10.1093/nc/niad026
Young, M. J., Koch, C., Claassen, J., Fischer, D., Aubinet, C., Gosseries, O., Kondziella, D., Rosanova, M., Sarasso, S., Casarotto, S., Massimini, M., & Edlow, B. L. (2025). An ethical framework to assess covert consciousness. The Lancet Neurology, 24(3), 195–196. https://doi.org/10.1016/ S1474-4422(24)00432-0
Zhou, D. W., Conte, M. M., Curley, W. H., Spencer-Salmon, C. A., Chatelle, C., Rosenthal, E. S., Bodien, Y. G., Victor, J. D., Schiff, N. D., Brown, E. N., & Edlow, B. L. (2024). Alpha coherence is a network signature of cognitive recovery from disorders of consciousness. medRxiv: The Preprint Server for Health Sciences, 2024.10.08.24314953. https://doi.org/10.1101/2024.10.08.24314953
