EEG characteristics of central nervous system graft-versus-host disease.

[en] In this multicenter retrospective study, we analyzed the EEG characteristics of 17 patients with possible CNS graft-versus-host disease (pCNS-GvHD). All EEGs were abnormal. Most (11/17 patients) showed background activity slowing. Sporadic epileptiform discharges were rare (2 patients) and observed only in chronic pCNS-GvHD. Sporatic non-epileptiform discharges, often generalized, frontally predominant, and triphasic, were common (15/17 patients). Two patients presented generalized rhythmic delta activity, one showed lateralized rhythmic delta activity, and one exhibited lateralized periodic discharges. Background activity slowing was statistically associated with higher one-year overall mortality (P=0.026). These findings suggest that EEG may serve as a prognostic tool in CNS-GvHD.

Disciplines :

Neurology
Hematology

Author, co-author :

Lambert, Nicolas ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

El Moussaoui, Majdouline ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Maladies infectieuses et médecine interne générale

Brijs, Jan ; Department of Hematology, University Hospitals Leuven, 3000 Leuven, Belgium

Chauvet, Paul ; CHU de Lille, Maladies du Sang, Université de Lille, 59000 Lille, France

Santoro, Jonathan D; Division of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, 90027 Los Angeles, California, USA

Gil-Perotín, Sara ; Research Group in Immunotherapy and Biomodels for Autoimmunity, Instituto de Investigación Sanitaria La Fe, Neuoimmunology Unit-Department of Neurology, Hospital Universitari i Politècnic la Fe, 46026 Valencia, Spain

Servais, Sophie ; Université de Liège - ULiège > Département des sciences cliniques ; Department of Cancerology-Hematology, University of Luxembourg and Centre Hospitalier de Luxembourg, Luxembourg

Willems, Evelyne ; Université de Liège - ULiège > Département des sciences cliniques

Baron, Frédéric ; Université de Liège - ULiège > Département des sciences cliniques

Beguin, Yves ; Université de Liège - ULiège > Département des sciences cliniques

More authors (3 more)

Language :

English

Title :

EEG characteristics of central nervous system graft-versus-host disease.

Publication date :

27 May 2025

Journal title :

Journal of Neurophysiology

ISSN :

0022-3077

eISSN :

1522-1598

Publisher :

American Physiological Society, United States

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://journals.physiology.org/doi/pdf/10.1152/jn.00142.2025

Available on ORBi :

since 30 May 2025

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