[en] Characteristic preterm EEG patterns of "Delta-brushes" (DBs) have been reported in the temporal cortex following auditory stimuli, but their spatio-temporal dynamics remains elusive. Using 32-electrode EEG recordings and co-registration of electrodes' position to 3D-MRI of age-matched neonates, we explored the cortical auditory-evoked responses (AERs) after 'click' stimuli in 30 healthy neonates aged 30-38 post-menstrual weeks (PMW). (1) We visually identified auditory-evoked DBs within AERs in all the babies between 30 and 33 PMW and a decreasing response rate afterwards. (2) The AERs showed an increase in EEG power from delta to gamma frequency bands over the middle and posterior temporal regions with higher values in quiet sleep and on the right. (3) Time-frequency and averaging analyses showed that the delta component of DBs, which negatively peaked around 550 and 750 ms over the middle and posterior temporal regions, respectively, was superimposed with fast (alpha-gamma) oscillations and corresponded to the late part of the cortical auditory-evoked potential (CAEP), a feature missed when using classical CAEP processing. As evoked DBs rate and AERs delta to alpha frequency power decreased until full term, auditory-evoked DBs are thus associated with the prenatal development of auditory processing and may suggest an early emerging hemispheric specialization.
Disciplines :
Pediatrics
Author, co-author :
Kaminska, A; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France ; Department of Clinical Neurophysiology, AP-HP, Necker-Enfants Malades Hospital, Paris, France
Delattre, V; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France ; Neurospin, UNIACT, CEA, Gif sur Yvette, France
Laschet, J; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France
Dubois, J; INSERM U992, CEA/DRF/I2BM/Neurospin/UNICOG, Gif-sur-Yvette, France ; Paris Saclay University, Paris-Sud University, Gif-sur-Yvette, France
Labidurie, M; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France
Duval, A; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France ; Neurospin, UNIACT, CEA, Gif sur Yvette, France
Manresa, A; Laboratory of Psychology and Neurosciences (LPN) (EA 47000), Rouen University, Rouen, France
Magny, J-F; Neonatal Intensive Care Unit, AP-HP, Necker-Enfants Malades Hospital, Paris, France
Hovhannisyan, S; Neonatal Intensive Care Unit, AP-HP, Necker-Enfants Malades Hospital, Paris, France
Mokhtari, M; Neonatal Intensive Care Unit, AP-HP, Bicetre Hospital, Kremlin-Bicetre, France
Ouss, Lisa ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie infanto-juvénile ; Department of Pediatric Neurology, AP-HP, Necker-Enfants Malades Hospital, Paris, France
Boissel, A; Laboratory of Psychology and Neurosciences (LPN) (EA 47000), Rouen University, Rouen, France
Hertz-Pannier, L; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France ; Neurospin, UNIACT, CEA, Gif sur Yvette, France
Sintsov, M; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia
Minlebaev, M; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia ; INSERM U901/ INMED, Aix-Marseille University, Marseille, France
Khazipov, R; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia ; INSERM U901/ INMED, Aix-Marseille University, Marseille, France
Chiron, C; INSERM U1129, Paris, France ; Paris Descartes University, Sorbonne Paris Cité, Paris, France ; CEA, 91191 Gif sur Yvette, France
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