Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase-19 deficient mice

[en] Matrix metalloproteinase 19 (MMP-19) is a member of the MMP family of endopeptidases that, in contrast to most MMPs, is widely expressed in human tissues under normal quiescent conditions. MMP-19 has been found to be associated with ovulation and angiogenic processes and is deregulated in diverse pathological conditions such as rheumatoid arthritis and cancer. To gain further insights into the in vivo functions of this protease, we have generated mutant mice deficient in Mmp19. These mice are viable and fertile and do not display any obvious abnormalities. However, Mmp19-null mice develop a diet-induced obesity due to adipocyte hypertrophy and exhibit decreased susceptibility to skin tumors induced by chemical carcinogens. Based on these results, we suggest that this enzyme plays an in vivo role in some of the tissue remodeling events associated with adipogenesis, as well as in pathological processes such as tumor progression

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Pendas, A. M.

Folgueras, A. R.

LLano, E.

Caterina, J.

Frerard, F.

Rodriguez, F.

Astudillo, A.

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Birkedal-Hansen, H.

Lopez-Otin, C.

Language :

English

Title :

Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase-19 deficient mice

Publication date :

2004

Journal title :

Molecular and Cellular Biology

ISSN :

0270-7306

eISSN :

1098-5549

Publisher :

American Society for Microbiology (ASM), Washington, United States - District of Columbia

Volume :

Issue :

Pages :

5304-13

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 December 2009

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