[en] IntroductionAllostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer’s disease (AD) in a healthy elderly population and with a multimodal approach.MethodsAt baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.ResultsAL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.DiscussionAL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
Disciplines :
Neurosciences & behavior
Author, co-author :
Palix, Cassandre
Chauveau, Léa
Felisatti, Francesca
Chocat, Anne
Coulbault, Laurent
Hébert, Oriane
Mézenge, Florence
Landeau, Brigitte
Haudry, Sacha
Fauvel, Séverine
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie
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