Reference : Uncoupling proteins outside the animal and plant kingdoms: functional and evolutionar...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Uncoupling proteins outside the animal and plant kingdoms: functional and evolutionary aspects.
Sluse, Francis mailto [Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Jarmuszkiewicz, W. [ > > ]
FEBS Letters
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Mitochondrion ; uncoupling protein ; Alternative oxidase ; Acanthamoeba castellanii ; candida parapsilosis ; Dictyostelium discoideum
[en] The appearance of intracellular oxidative phosphorylation at the time of acquisition of mitochondria in Eukarya was very soon accompanied by the emergence of uncoupling protein, a carrier specialized in free fatty acid-mediated H(+) recycling that can modulate the tightness of coupling between mitochondrial respiration and ATP synthesis, thereby maintaining a balance between energy supply and demand in the cell and defending cells against damaging reactive oxygen species production when electron carriers of the respiratory chain become over-reduced. The simultaneous occurrence of redox free energy-dissipating oxidase, which has the same final effect, could be related to the functional interactions between both dissipative systems

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