Thiamine; energy metabolism; phosphorylated derivatives; thiamine deficiency diseases
Abstract :
[en] Vitamin B1 is an indispensable food factor for the human and animal body. In animals, vitamin B1 is found in the form of thiamine and its phosphate esters - thiamine mono-, di- and triphosphate, as well as an adenylated derivative - adenosine thiamine triphosphate. At present, the only vitamin B1 form with biochemical functions being elucidated is thiamine diphosphate, which serves as a coenzyme for several important enzymes involved in carbohydrate, amino acid, fatty acid and energy metabolism. Here we review the latest developments in the field of vitamin B1 research in animals. Transport, metabolism and biological role of thiamine and its derivatives are considered as well as the involvement of vitamin B1-dependent processes in human diseases and its therapeutic issues, a field that has gained momentum with several important recent developments.
Research Center/Unit :
GIGA Neurosciences-Neurophysiology - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Makarchikov, Alexander F; Grodno State Agrarian University, 28 Tereshkova St., 230005 Grodno, Belarus, Institute of Biochemistry of Biologically Active Compounds of NAS of Belarus, 7 Antoni Tyzenhauz Square, 230023 Grodno, Belarus
Wins, Pierre ; Université de Liège - ULiège > Département des sciences cliniques
Bettendorff, Lucien ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Language :
English
Title :
BIOCHEMICAL AND MEDICAL ASPECTS OF VITAMIN B1 RESEARCH.
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