[en] The functional organisation of the medial temporal lobe (MTL) has long been described on the basis of cognitive processes such as recollection or familiarity. However, this view has recently been challenged, and researchers have proposed decomposing cognitive phenomena into representations and operations. According to the representational view, representations, such as scenes for the hippocampus and objects for the perirhinal cortex, are critical in understanding the role of MTL regions in cognition. In the present study, 51 healthy young participants underwent functional magnetic resonance imaging (fMRI) while completing a visual-discrimination task. Subsequently, half of the participants performed a patch-cue recognition procedure in which "Rec" responses are believed to reflect the operation of pattern completion, whereas the other half performed a whole-item remember/know procedure. We replicated the previously-reported demonstration that hippocampal involvement in pattern completion is preferential for scenes as compared with objects. In contrast, the perirhinal cortex was more recruited for object processing than for scene processing. We further extended these results to the operations of strength-signal memory and visual discrimination. Finally, the modulation of hippocampal engagement in pattern completion by representational content was found to be specific to its anterior segment. This observation is consistent with the proposal that this segment would process broad/global representations, whereas the posterior hippocampus would perform sharp/local representations. Taken together, these results favour the representational view of MTL functional organisation, but support that this specialisation differs along the hippocampal long-axis.
Disciplines :
Neurosciences & behavior
Author, co-author :
Gardette, Jeremy ; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France
Cousin, Emilie; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France
Bourgin, Jessica; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France
Torlay, Laurent; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France
Pichat, Cédric; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France
Moreaud, Olivier; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France, Centre Mémoire de Ressources et de Recherche, Pôle de Psychiatrie et Neurologie, CHU Grenoble, Grenoble, France
Hot, Pascal ; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France, Institut Universitaire de France, France. Electronic address: pascal.hot@univ-smb.fr
Language :
English
Title :
Hippocampal activity during memory and visual perception: The role of representational content.
Publication date :
December 2022
Journal title :
Cortex: A Journal Devoted to the Study of the Nervous System and Behavior
We thank Rosemary Cowell and David Ross for sharing with us the material, data, and analysis details from the original study. We thank Stéphane Rousset and Maëlle Tixier for helpful theoretical discussions on the project, Laurent Lamalle for technical assistance, and Alexia Roux-Sibilon for methodological advice. We thank the Savoie-Mont-Blanc University for financial support.
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