Synthesis of polymeric mimics of ice-binding proteins

[en] Cobalt-mediated radical polymerization (CMRP) enables the preparation of both short and long polymers from acrylic and vinyl ester monomers with low dispersity. Here we describe the synthesis, purification, and characterization of polymeric mimics of ice-binding proteins based on the water-soluble polymer poly(vinyl alcohol) by CMRP. Block copolymers of poly(vinyl alcohol) and poly(acrylic acid) were prepared from the precursor copolymers poly(vinyl acetate)-b-poly(acrylonitrile) upon hydrolysis. Copolymers comprising up to hundreds of monomers and dispersities Mw/Mn < 1.3 were produced by this method.

Research Center/Unit :

CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège [BE]
CERM - Center for Education and Research on Macromolecules - ULiège [BE]

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Sproncken, Christian C M; Eindhoven University of Technology - Department of Chemical Engineering and Chemistry & Institute for Complex Molecular Systems - Netherlands

Detrembleur, Christophe ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium

Voets, Ilja K ; Eindhoven University of Technology - Department of Chemical Engineering and Chemistry & Institute for Complex Molecular Systems - Netherlands

Language :

English

Title :

Synthesis of polymeric mimics of ice-binding proteins

Publication date :

2024

Main work title :

Ice binding proteins: methods and protocols

Author, co-author :

Drori, Ron

Stevens, Corey

Publisher :

Springer

ISBN/EAN :

978-1-0716-3502-5

Collection name :

Methods in Molecular Biology

Collection ISSN :

1064-3745

Pages :

203-210

Peer reviewed :

Peer reviewed

Funders :

F.R.S.-FNRS - Fund for Scientific Research
EU - European Union
NWO - Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Funding text :

This work is financially supported by the European Union (ERC-2020-CoG contract no. 101001965) and the Dutch Science Foundation (NWO ECHO grant no. 712.016.002). C.D. is Research Director of F.R.S.-FNRS and thanks FNRS (Belgium) for financial support.

Available on ORBi :

since 10 March 2025

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Bibliography

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