Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry

[en] Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to the G-quadruplex delays the unwinding of the quadruplex structure and formation of the duplex.

Research Center/Unit :

CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège

Disciplines :

Chemistry
Biochemistry, biophysics & molecular biology

Author, co-author :

Rosu, Frédéric ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse

Gabelica, Valérie ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse

Shin-ya, Kazuo

De Pauw, Edwin ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse

Language :

English

Title :

Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry

Publication date :

2003

Journal title :

Chemical Communications

ISSN :

1359-7345

eISSN :

1364-548X

Publisher :

Royal Society of Chemistry (RSC), Cambridge, United Kingdom

Issue :

Pages :

2702-2703

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 21 July 2008

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