手性农药丁氟螨酯对斑马鱼胚胎的选择性发育毒性

Although the developmental toxicity of cyflumetofen (CYF) to non-target organisms has become a significant concern in recent years, its enantioselective effects on aquatic organisms are poorly understood. To evaluate the enantioselective toxicity of CYF on zebrafish, zebrafish embryos were exposed to a series of isometric concentrations of two CYF enantiomers and the CYF racemate (Rac) for 96 h. In addition, the effect of three compounds on hatching rate, yolk sac edema, pericardial edema, and curved body axis were investigated. According to the acute toxicity results, S-CYF and Rac-CYF were higher than R-CYF, the toxicity of S-CYF was 2.3 times higher than R-CYF. At 500 mg•L-1, and the S-CYF could significantly induce developmental abnormities including yolk sac edema, pericardial edema, curved body axis (p < 0.05) at 72 hpf, while only the Rac-CYF could decrease the hatching rate. It's been noticeable a regulation was apparent in this study, the developmental toxicity was consistent with acute toxicity (S-CYF>Rac-CYF>R-CYF). This work demonstrated the obvious of enantioselectivity in developmental toxicity of CYF to zebrafish embryos, which could be considered in environmental risk assessment. © 2021, Science Press. All right reserved.